Hemophagocytosis of the Hilar Pulmonary Lymph Nodes Is a More Sensitive Indicator of the Severity of COVID-19 Disease than Bone Marrow Hemophagocytosis DOI Creative Commons

Amira Jusovic-Stocanin,

Elke Kaemmerer,

Hannah Ihle

et al.

Diseases, Journal Year: 2024, Volume and Issue: 12(10), P. 241 - 241

Published: Oct. 3, 2024

In systemic hyper-inflammation, as in severe COVID-19 disease, there are pronounced disorders of the hematological and lymphatic systems with prognostically relevant hemophagocytosis bone marrow. The current work aimed to address importance lymph nodes patients disease. From 28 who died infection, samples vertebral marrow from cervical, hilar, para-aortic, mesenteric inguinal locations were morphologically immunohistologically (CD163, CD68, CD61, CD71, CD3, CD20, CD138) examined for possible presence hemophagocytosis. single-center study at University Hospital Jena, a total 191 hemophagocytes found 780 standardized area 21,924 mm2 per tissue sample. With 370 hemophagocytes, hilar most frequently affected (370/780; 47.44%; 95%-CI: [43.94, 50.95]), followed by cervical (206/780; 26.41%; [23.41, 29.59]), para-aortic (125/780; 16.03%; [13.58, 18.73]) inguinal/mesenteric (79/780; 10.13%; [8.155, 12.4]). Based on standard (21,924 mm2), difference number was statistically significant (p < 0.05), while this did not apply other locations. fatal is particularly therefore better indicator severity disease than findings provide some evidence concept compartmentalized human host responses life-threatening infections.

Language: Английский

4-amino-5-(pyridin-4-yl)-4H-1,2,4-triazole-3-thiol as potent antimicrobial agent: Synthesis, X-ray, antimicrobial activity and computational studies DOI

Khouloud Rouzi,

Silvia Antonia Brandán,

Imane El Houssni

et al.

Journal of Molecular Structure, Journal Year: 2024, Volume and Issue: 1320, P. 139613 - 139613

Published: Aug. 22, 2024

Language: Английский

Citations

4
Novel 1,3,4‐Oxadiazole Acetamide Derivatives as Potential Antimicrobial Agents: Design, Synthesis, Biological Evaluation, and Molecular Modelling Studies DOI

Khouloud Rouzi,

Imane El Houssni,

Njabulo Joyfull Gumede

et al.

ChemistrySelect, Journal Year: 2025, Volume and Issue: 10(12)

Published: March 1, 2025

Abstract In this work, a series of novel 1,3,4‐oxadiazole‐acetamide analogs ( 3a‐j ) were designed and constructed. The newly synthesized compounds characterized by 1 H NMR, 13 C ESI‐HRMS. Compounds evaluated for their efficacy as antimicrobial agents against wide range pathogenic fungi strains. results revealed possessed excellent activities, among them, 3a‐3g , 3i 3j showed remarkable activity with an MIC value 1.95 µg/mL, superior to that positive controls. Molecular modeling techniques, such induced fit docking (IFD) molecular mechanics generalized born surface area (MM‐GB/SA), utilized elucidate the binding modes affinities candidate compounds. suggested most potent demonstrated therapeutically significant bacterial drug targets, including 1KNZ, 2XCT, 4HOE, ΔG energies ranging from −44.0 −77.49 kcal/mol. Furthermore, geometry optimization structures through application density functional theory (DFT) was performed simulate electronic properties, which encompass HOMO–LUMO energies/band gaps electrostatic potential maps. outcomes indicated 3d 3e 3f 3h exhibit nucleophilic characteristics, heightened HOMO diminished band gap energies. These findings forces influencing compounds' inhibit strains under study.

Language: Английский

Citations

0
Regional specialization within the mammalian respiratory immune system DOI
David P. Hoytema van Konijnenburg,

Peter A. Nigrovic,

Ivan Zanoni

et al.

Trends in Immunology, Journal Year: 2024, Volume and Issue: 45(11), P. 871 - 891

Published: Oct. 21, 2024

Language: Английский

Citations

2
Hemophagocytosis of the Hilar Pulmonary Lymph Nodes Is a More Sensitive Indicator of the Severity of COVID-19 Disease than Bone Marrow Hemophagocytosis DOI Creative Commons

Amira Jusovic-Stocanin,

Elke Kaemmerer,

Hannah Ihle

et al.

Diseases, Journal Year: 2024, Volume and Issue: 12(10), P. 241 - 241

Published: Oct. 3, 2024

In systemic hyper-inflammation, as in severe COVID-19 disease, there are pronounced disorders of the hematological and lymphatic systems with prognostically relevant hemophagocytosis bone marrow. The current work aimed to address importance lymph nodes patients disease. From 28 who died infection, samples vertebral marrow from cervical, hilar, para-aortic, mesenteric inguinal locations were morphologically immunohistologically (CD163, CD68, CD61, CD71, CD3, CD20, CD138) examined for possible presence hemophagocytosis. single-center study at University Hospital Jena, a total 191 hemophagocytes found 780 standardized area 21,924 mm2 per tissue sample. With 370 hemophagocytes, hilar most frequently affected (370/780; 47.44%; 95%-CI: [43.94, 50.95]), followed by cervical (206/780; 26.41%; [23.41, 29.59]), para-aortic (125/780; 16.03%; [13.58, 18.73]) inguinal/mesenteric (79/780; 10.13%; [8.155, 12.4]). Based on standard (21,924 mm2), difference number was statistically significant (p < 0.05), while this did not apply other locations. fatal is particularly therefore better indicator severity disease than findings provide some evidence concept compartmentalized human host responses life-threatening infections.

Language: Английский

Citations

0