Advances in Clinical Medicine, Journal Year: 2024, Volume and Issue: 14(08), P. 1282 - 1289
Published: Jan. 1, 2024
Language: Английский
Published: Jan. 1, 2025
The oxidative damage to vascular endothelial cells induced by smoking represents a significant pathogenic factor in the development of atherosclerosis. In present study, we isolated ginseng oligopeptide extract (GOE), which emerges as promising candidate for protecting human aortic (HAECs) from stress nicotine. underlying mechanisms were also explored. GOE effectively reversed decline cell viability and protected HAECs BaP-induced inhibiting overproduction intracellular reactive oxygen species (ROS) while preserving superoxide dismutase (SOD) activity. We identified five oligopeptides (GOPs) primary components GOE. Furthermore, demonstrated that significantly alleviated nicotine-induced mitochondrial dysfunction promoting nitric oxide (NO) release expression GTP cyclohydrolase 1 (GTPCH1). Although precise mechanism through mitigates remains be fully elucidated, our findings indicate GOP-1~5 serve bioactive constituents play synergistic role reducing apoptosis damages HAECs. This is achieved modulation cellular antioxidant systems via maintaining balance within Keap1/Nrf2/HO-1 signaling pathway. These suggest may function potential therapeutic agent against cigarette smoking-induced
Language: Английский
Citations
0
Frontiers in Cardiovascular Medicine, Journal Year: 2025, Volume and Issue: 11
Published: Jan. 6, 2025
Obesity is one of the major global health concerns 21st century, associated with many comorbidities such as type 2 diabetes mellitus (T2DM), metabolic dysfunction-associated steatotic liver disease, and early aggressive atherosclerotic cardiovascular which leading cause death worldwide. Bile acids (BAs) incretins are gut hormones involved in digestion absorption fatty acids, insulin secretion, respectively. In recent years BAs increasingly recognized key signaling molecules, target multiple tissues organs, beyond gastro-intestinal system. Moreover, incretin-based therapy has revolutionized treatment T2DM obesity. This mini review highlights current knowledge about dysregulations BA homeostasis obesity a special focus on atherosclerosis well athero-modulating roles currently available therapies.
Language: Английский
Citations
0
Medicine, Journal Year: 2025, Volume and Issue: 104(5), P. e41361 - e41361
Published: Jan. 31, 2025
The role of circulating immune cells in coronary atherosclerosis remains unclear. This study aimed to assess the causal effects various on using Mendelian randomization (MR). Circulating cell datasets were obtained from genome-wide association studies, and FinnGen. Single-nucleotide polymorphisms satisfying assumptions association, independence, exclusivity screened analyzed MR, with inverse-variance weighted as main method. Horizontal pleiotropy, heterogeneity, sensitivity analyses performed MR-Egger, Cochran Q, leave-one-out analyses, respectively. MR analysis showed that effector memory double negative (DN) (cluster differentiation [CD]4-CD8-) %DN (odds ratio [OR]: 1.042, 95% confidence interval [CI]: 1.008-1.077, P = .014), CD4 CD39+ CD4+ (OR: 1.027, CI: 1.001-1.054, .040), C-X3-C motif chemokine receptor 1 CD14+ CD16- monocytes 1.035, 1.010-1.060, .006), C-C 7 naive 1.006-1.076, .023), immunoglobulin D- CD38- %lymphocytes 1.098, 1.016-1.187, .019) associated an increased genetic susceptibility atherosclerosis, no horizontal pleiotropy (P ≥ .05). Q heterogeneity .05), indicated results robust. revealed markers subsets, including DN (CD4-CD8-) %DN, CD4+, monocytes, IgD- %lymphocytes, atherosclerosis. provides a explanation for specific inducing exacerbating artery disease offers new ideas exploration immune-targeted drugs.
Language: Английский
Citations
0
The Science of The Total Environment, Journal Year: 2025, Volume and Issue: 967, P. 178822 - 178822
Published: Feb. 14, 2025
Language: Английский
Citations
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Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(7), P. 2352 - 2352
Published: March 29, 2025
Atherosclerosis remains a leading cause of cardiovascular morbidity and mortality worldwide, traditionally linked to elevated cholesterol levels, particularly low-density lipoprotein (LDL-C). However, despite aggressive lipid-lowering strategies, residual risk persists, underscoring the need explore additional contributing factors. This review examines emerging factors beyond cholesterol, including chronic inflammation, gut microbiota composition, oxidative stress, environmental exposures. Inflammation plays pivotal role in atherogenesis, with markers such as C-reactive protein (CRP), interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α) serving indicators disease activity. The microbiome, metabolites like trimethylamine N-oxide (TMAO), has been implicated vascular inflammation plaque development, while beneficial short-chain fatty acids (SCFAs) demonstrate protective effects. Oxidative stress further exacerbates endothelial dysfunction instability, driven by reactive oxygen species (ROS) lipid peroxidation. Additionally, factors, air pollution, heavy metal exposure, endocrine disruptors, psychological have emerged significant contributors disease. Understanding these novel offers broader perspective on atherosclerosis pathogenesis provides new avenues for targeted prevention therapeutic interventions.
Language: Английский
Citations
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International Journal of Medical Sciences, Journal Year: 2024, Volume and Issue: 21(14), P. 2683 - 2693
Published: Jan. 1, 2024
Alterations in circulating CCL4 levels have been implicated coronary artery disease (CAD), but the causal relationship and underlying mechanisms remain unclear.
Language: Английский
Citations
1
Advances in Clinical Medicine, Journal Year: 2024, Volume and Issue: 14(08), P. 1282 - 1289
Published: Jan. 1, 2024
Language: Английский
Citations
0