Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)
Published: Dec. 24, 2024
Extensive research is needed to examine the association between cardiovascular disease (CVD) and cancer. The observational study based on data collected from 2005–2018 National Health Nutrition Examination Survey (NHANES). To assess connection CVDs cancer, we used a weighted multivariable logistic regression analysis with as many confounding factors feasible included in model. By employing Mendelian randomization (MR), unbiased causal relationship cancers was ascertained. primary analytical approach employed Inverse Variance Weighted methodology. In cross-sectional study, positive correlation observed CVD cancer (Model 3, Odds ratio 1.26, 95% confidence interval 1.01 ~ 1.57, p = 0.040). However, MR indicated negative certain subtypes of specific cancers, effect sizes for coronary heart lung (β − 4.759, 0.002), breast 2.684, 0.026), colorectal 4.581, 0.042), liver 19.264, 0.028), stroke prostate 0.299, 0.017), no evidence correlation. Results reverse revealed angina pectoris. An linked risk risk. has shown that expected incidence can reduce probability developing forms Further investigation required clinical correlations underlying processes these two illnesses.
Language: Английский