Adipose-derived small extracellular vesicle miR-146a-5p targets Fbx32 to regulate mitochondrial autophagy and delay aging in skeletal muscle DOI Creative Commons
Mengran Qin, Yizhen Wang,

Zihan Wang

et al.

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: April 10, 2025

This study investigates how miR-146a-5p, found in adipose tissue-derived small extracellular vesicles (sEV), influences mitochondrial autophagy and its impact on delaying skeletal muscle aging through the targeting of Fbx32. The findings highlight miR-146a-5p as crucial development aging, influencing autophagy, apoptosis, differentiation, proliferation, collectively impacting atrophy. In C2C12 cells, mimics decreased reactive oxygen species (ROS) levels, while enhancing ATP production; conversely, inhibitors had opposite effects. Furthermore, miR-146a-5p-enriched sEV from tissue alleviated atrophy aged mice promoted fiber growth repair by regulating apoptosis. Mechanistically, modulated myoblasts Fbx32 FoxO3 signaling pathway. led to a notable decrease apoptosis-related gene expression, reduced ROS production, elevated levels. conclusion, derived WAT-sEV modulates myoblast ROS, differentiation Fbx32/FoxO3 axis. work presents novel molecular target theoretical framework for developing therapies muscle-related disorders.

Language: Английский

Non-coding RNAs participate in interactions between senescence and gastrointestinal cancers DOI Creative Commons
Zhaozhe Liu,

Fa-He Ji,

Ying Piao

et al.

Frontiers in Genetics, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 3, 2025

Relationships between cellular senescence and gastrointestinal cancers have gained prominence in recent years. The currently accepted theory suggests that cancer occurrence exhibit "double-edged sword" effects. Cellular is related to via four "meta-hallmarks" i.e., genomic instability, epigenetic alterations, chronic inflammation, dysbiosis, along with two "antagonistic hallmarks" telomere attrition stem cell exhaustion. These relationships are characterized by both agonistic antagonistic elements, but the existence of an intricate dynamic balance remains unknown. Non-coding RNAs (ncRNAs) vital roles post-transcriptional regulation, how they participate be fully investigated. In this article, we systematically review ncRNAs (including microRNAs (miRNAs), long (lncRNAs), circularRNAs (circRNAs)) interactions cancers. Our aim elucidate a triangular relationship "ncRNAs-senescence-gastrointestinal cancers" which considered these three elements as equal important standing. We keen identify prognostic or therapeutic targets for from, aging-related ncRNAs, discover novel strategies treat manage elderly. seek clarify complex where "senescence-gastrointestinal interactions.

Language: Английский

Citations

0
Innovative applications and research progress of hepatic arterial infusion chemotherapy in the treatment of advanced hepatocellular carcinoma DOI

Ting-Fang Yang,

Mo-Wei Kong

World Journal of Gastrointestinal Oncology, Journal Year: 2025, Volume and Issue: 17(2)

Published: Jan. 18, 2025

This article provides an in-depth analysis of the study conducted by Wang et al, which explores hepatic arterial infusion chemotherapy and its synergistic strategies in managing advanced hepatocellular carcinoma (HCC). HCC ranks as fourth most common cause cancer-related mortality globally is frequently associated with portal vein tumor thrombus (PVTT). The approach to HCC, particularly when PVTT present, diverges markedly between Eastern Western practices. These differences are rooted variations epidemiology, etiology, pathology, comorbidities, prognosis. paper delves into diagnosis, classification, treatment for PVTT, well evolving role advancements therapeutic landscape HCC.

Language: Английский

Citations

0
A bibliometric analysis of exosomes in aging from 2007 to 2023 DOI Creative Commons

Zenghui Niu,

Mengge Cui,

Yingkun Fu

et al.

Frontiers in Medicine, Journal Year: 2025, Volume and Issue: 11

Published: Jan. 22, 2025

Background Aging is the primary factor contributing to development of aging-related diseases. As research on exosomes continues advance, its relationship with aging and diseases has become a hot topic This article analyzes hotspots in diseases, aiming fill gap bibliometric this field help researchers better understand current status future trends both fundamental clinical field. Methods The articles were retrieved exported from WoSCC December 18, 2023. visual analysis countries regions, institutions, authors, references, keywords was conducted using VOSviewer 1.6.18, CiteSpace 6.2.R7, Bibliometrix. Results included 1628 articles. China United States emerged as top two leading A total 2,321 institutions 78 regions primarily led by States. Both Kapogiannis D Goetzl E active authors Thery C, Valadi H, Raposo G important promoters C proposed method differential centrifugation density gradient extract exosomes. H discovered cells could send RNA-messages each other loading them into exosome-vesicles. journal highest number International Journal Molecular Sciences , while PLoS One most frequently cited journal. keyword revealed that will possibly focus “inflammation, cellular senescence, angiogenesis, insulin resistance, Alzheimer's disease.” Conclusion We identified through analysis. present study provides valuable new perspectives history also offering guidance for directions.

Language: Английский

Citations

0
Regulatory Roles of Exosomes in Aging and Aging-Related Diseases DOI

Nanyin Xiao,

Li Qiao, Guangyu Liang

et al.

Biogerontology, Journal Year: 2025, Volume and Issue: 26(2)

Published: Feb. 18, 2025

Language: Английский

Citations

0
Metabolic reprogramming in cancer and senescence DOI Creative Commons
Yuzhu Zhang, J. Tang, Can Jiang

et al.

MedComm, Journal Year: 2025, Volume and Issue: 6(3)

Published: March 1, 2025

The rising trend in global cancer incidence has caused widespread concern, one of the main reasons being aging population. Statistical data show that and mortality rates a clear upward with age. Although there is commonality between dysregulated nutrient sensing, which features aging, metabolic reprogramming tumor cells, specific regulatory relationship not clear. This manuscript intends to comprehensively analyze senescence reprogramming; as well reveal impact key factors leading cellular on tumorigenesis. In addition, this review summarizes current intervention strategies targeting sensing pathways, clinical cases treating tumors characteristics existing nanodelivery research strategies. Finally, it also suggests sensible dietary habits for those who wish combat aging. conclusion, attempts sort out link metabolism provide new ideas treatment.

Language: Английский

Citations

0
Exosomal Dynamics: Bridging the Gap Between Cellular Senescence and Cancer Therapy DOI Creative Commons

Babu Santha Aswani,

Anjana Sajeev, Mangala Hegde

et al.

Mechanisms of Ageing and Development, Journal Year: 2025, Volume and Issue: 225, P. 112045 - 112045

Published: March 11, 2025

Cancer remains one of the most devastating diseases, severely affecting public health and contributing to economic instability. Researchers worldwide are dedicated developing effective therapeutics target cancer cells. One promising strategy involves inducing cellular senescence, a complex state in which cells exit cell cycle. Senescence has profound effects on both physiological pathological processes, influencing systems through secreted factors that affect surrounding distant Among these exosomes, small extracellular vesicles play crucial roles communication, development, defense, can contribute conditions. Recently, there been increasing interest engineering exosomes as precise drug delivery vehicles, capable targeting specific or intracellular components. Studies have emphasized significant role from senescent progression therapy. Notably, chemotherapeutic agents alter tumor microenvironment, induce trigger immune responses exosome-mediated cargo transfer. This review explores intricate relationship between cancer, examining how different eliminate promote resistance. It also investigates molecular mechanisms signaling pathways driving highlighting current challenges proposing future perspectives uncover new therapeutic strategies for treatment.

Language: Английский

Citations

0
Adipose-derived small extracellular vesicle miR-146a-5p targets Fbx32 to regulate mitochondrial autophagy and delay aging in skeletal muscle DOI Creative Commons
Mengran Qin, Yizhen Wang,

Zihan Wang

et al.

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: April 10, 2025

This study investigates how miR-146a-5p, found in adipose tissue-derived small extracellular vesicles (sEV), influences mitochondrial autophagy and its impact on delaying skeletal muscle aging through the targeting of Fbx32. The findings highlight miR-146a-5p as crucial development aging, influencing autophagy, apoptosis, differentiation, proliferation, collectively impacting atrophy. In C2C12 cells, mimics decreased reactive oxygen species (ROS) levels, while enhancing ATP production; conversely, inhibitors had opposite effects. Furthermore, miR-146a-5p-enriched sEV from tissue alleviated atrophy aged mice promoted fiber growth repair by regulating apoptosis. Mechanistically, modulated myoblasts Fbx32 FoxO3 signaling pathway. led to a notable decrease apoptosis-related gene expression, reduced ROS production, elevated levels. conclusion, derived WAT-sEV modulates myoblast ROS, differentiation Fbx32/FoxO3 axis. work presents novel molecular target theoretical framework for developing therapies muscle-related disorders.

Language: Английский

Citations

0