Preparation, characterization and in vitro evaluation of 5-fluorouracil loaded into chitosan–acacia gum nanoparticles

Therapeutic Delivery, Journal Year: 2024, Volume and Issue: 15(5), P. 339 - 353

Published: March 12, 2024

Aim: In this study, we prepared, characterized and in vitro evaluated a 5-fluorouracil (5-FU)-loaded chitosan–acacia gum nanoparticles. Methods: Nanoparticles were for their size, charge, morphology encapsulation efficiency (EE%) followed by cellular investigations against HT-29 colon cancer cell line. Results: The nanoparticles exhibited spherical morphological size with 94.42% EE%. Free 5-FU showed fast fully cumulative release after 6 h while loaded into CS-AG NPs good entrapment slow, prolonged even 24 h. Enhanced IC50 the compared free line was reported high selectivity normal fibroblast cells. Conclusion: is promising nano-therapy cancer.

Language: Английский

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Nanotechnology in tissue engineering: expanding possibilities with nanoparticles

Nanotechnology, Journal Year: 2024, Volume and Issue: 35(39), P. 392002 - 392002

Published: June 28, 2024

Tissue engineering is a multidisciplinary field that merges engineering, material science, and medical biology in order to develop biological alternatives for repairing, replacing, maintaining, or boosting the functionality of tissues organs. The ultimate goal tissue create enhancing However, current landscape techniques presents several challenges, including lack suitable biomaterials, inadequate cell proliferation, limited methodologies replicating desired physiological structures, unstable insufficient production growth factors, which are essential facilitating communication appropriate cellular responses. Despite these there has been significant progress made recent years. Nanoparticles hold major role within realm nanotechnology due their unique qualities change with size. These particles, provide potential solutions issues met have helped propel its state prominence. substantial breakthroughs utilization nanoparticles over past two decades, full range addressing difficulties remains largely untapped. This fact advancements occurred relatively isolated pockets. In purpose this research conduct an in-depth investigation ways various types might be put use. addition this, it sheds light on challenges need conquered unlock maximum area.

Language: Английский

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Revolutionising health care: Exploring the latest advances in medical sciences

Journal of Global Health, Journal Year: 2023, Volume and Issue: 13

Published: Aug. 4, 2023

Recent years have seen a revolution in the domain of medical science, with ground-breaking discoveries changing health care as we once knew it [1].These advances considerably improved disease diagnosis, treatment, and management, improving patient outcomes quality life [2][3][4][5].These innovations range from creation novel medications treatments to utilization cutting-edge technologies.For instance, gene editing technologies like Clustered Regularly Interspaced Palindromic Repeats (CRISPR-Cas9) opened up new treatment options for genetic illnesses [6], while development mRNA vaccines has offered desperately needed response coronavirus 2019 (COVID-19) pandemic [7].Moreover, wearable technology telemedicine accessibility, convenience, personalization care, whereas 3D printing nanotechnology breakthroughs made possible create individualized implants drug delivery systems [8][9][10].This article examines some most recent developments research how they might completely change delivery.The selection process identifying latest sciences this was follows.We aimed showcase potential revolutionise practices significantly impact outcomes.We extensively searched reputable scientific journals, conferences, reports recognized organisations institutes.We included novelty significance advancements, their ability address existing challenges, level evidence supporting efficacy, widespread adoption implementation.By utilizing process, ensured that selected advancements represent diverse fields capacity drive significant diagnostics, modalities, delivery. REGENERATIVE THERAPY TREATMENTRegenerative medicine is rapidly growing field seeks restore, replace, or regenerate damaged tissues organs using variety approaches, including cell therapy, tissue engineering, therapy [11].

Language: Английский

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Biomedicial therapeutic potential of copper tannic acid coordination nanosheet with multiple catalytic properties

Materials Today Communications, Journal Year: 2024, Volume and Issue: 38, P. 108130 - 108130

Published: Jan. 15, 2024

Language: Английский

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Synergistic Nanoformulation: Streamlined One-Pot Synthesis Enhances Paclitaxel Functionalization Gold Nanoparticles for Potent Anticancer Activity

Cell Biochemistry and Biophysics, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 27, 2025

Language: Английский

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