Rational Design Strategies for Nanozymes

ACS Nano, Journal Year: 2023, Volume and Issue: 17(14), P. 13062 - 13080

Published: July 3, 2023

Nanozymes constitute an emerging class of nanomaterials with enzyme-like characteristics. Over the past 15 years, more than 1200 nanozymes have been developed, and they demonstrated promising potentials in broad applications. With diversification complexity its applications, traditional empirical trial-and-error design strategies no longer meet requirements for efficient nanozyme design. Thanks to rapid development computational chemistry artificial intelligence technologies, first-principles methods machine-learning algorithms are gradually being adopted as a easier means assist This review focuses on potential elementary reaction mechanisms rational nanozymes, including peroxidase (POD)-, oxidase (OXD)-, catalase (CAT)-, superoxide dismutase (SOD)-, hydrolase (HYL)-like nanozymes. The activity descriptors introduced, aim providing further guidelines active material screening. computing- data-driven approaches thoroughly reviewed give proposal how proceed next-generation paradigm At end this review, personal perspectives prospects challenges put forward, hoping promote toward superior application performance future.

Language: Английский

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Nature meets technology: Harnessing nanotechnology to unleash the power of phytochemicals

Deleted Journal, Journal Year: 2024, Volume and Issue: 5(2), P. 200139 - 200139

Published: April 10, 2024

Phytochemicals encompass a diverse array of bioactive substances originating from plants, exhibiting broad spectrum possible health-promoting effects. Nonetheless, the clinical uses these compounds are restricted due to their limited solubility, stability, bioavailability, and target selectivity. Nanotechnology-based delivery methods present viable approach address problems enhance properties biological activity phytochemicals. Nanoformulations have potential augment pharmacokinetics phytochemicals by means several methods. One surface area solubility is lowering particle size. The process adsorption surfactants onto phytochemical particles can lead formation micelles, which exhibit in water. uptake across many barriers, including intestinal epithelium. To study nanoformulation enhancing therapeutic action Performed systemic review while considering PRISM guidelines. nanoparticles great delivering could help management various diseases. Although, exhaustive research trials yet demanded provide evidential proof for same. In conclusion, utilisation ligand-functionalized enables precise targeting particular cells or tissues. field nanotechnology has significant promise transforming advancement administration medicinal preventative applications. holds addressing obstacles related physicochemical characteristics phytochemicals, hence enabling development enhanced systems advantageous molecules.

Language: Английский

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Current status of Cancer Nanotheranostics: Emerging strategies for cancer management

Nanotheranostics, Journal Year: 2023, Volume and Issue: 7(4), P. 368 - 379

Published: Jan. 1, 2023

Cancer diagnosis and management have been a slow-evolving area in medical science.Conventional therapies by far proved to various limitations.Also, the concept of immunotherapy which was thought revolutionize cancer has presented its range drawbacks.To overcome these limitations nanoparticulate-derived diagnostic therapeutic strategies are emerging.These nanomaterials be explored as they serve prospect for theranostics.Nanoparticles significant yet unclear role screening well therapy cancer.However, nanogels Photodynamic is one such approach developed theranostics.Photoactive theranostics vivid that might prove help manage cancer.Also, utilization quantum dots tool selectively kill cells, especially CNS tumors.Additionally, redox-sensitive micelles targeting tumor microenvironment also an important theranostic tool.This review focuses on exploring agents currently being studied or can further theranostics.

Language: Английский

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Phytoestrogens: Chemistry, potential health benefits, and their medicinal importance

Phytotherapy Research, Journal Year: 2024, Volume and Issue: 38(6), P. 3060 - 3079

Published: April 11, 2024

Abstract Phytoestrogens, also known as xenoestrogens, are secondary metabolites derived from plants that have similar structures and biological effects human estrogens. These compounds do not directly affect functions but can act agonists or antagonists depending on the level of endogenous estrogen in body. Phytoestrogens may an epigenetic mechanism action independent receptors. found more than 300 plant species synthesized through phenylpropanoid pathway, with specific enzymes leading to various chemical structures. primarily phenolic compounds, include isoflavonoids, flavonoids, stilbenes, lignans. Extensive research animals humans has demonstrated protective phytoestrogens estrogen‐dependent diseases. Clinical trials shown their potential benefits conditions such osteoporosis, Parkinson's disease, certain types cancer. This review provides a concise overview phytoestrogen classification, diversity, biosynthesis discusses therapeutic phytoestrogens, well preclinical clinical development.

Language: Английский

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Phytochemical Loaded Nanovehicles of Biopolymer for Breast Cancer: A Systemic Review

Clinical Complementary Medicine and Pharmacology, Journal Year: 2023, Volume and Issue: 3(4), P. 100114 - 100114

Published: Sept. 9, 2023

Breast cancer is one of the most common malignancies affecting women worldwide, emphasizing need for effective therapeutic strategies. Phytochemicals derived from plants have gained significant attention due to their potential anticancer properties. This review aims comprehensively assess existing literature on using phytochemical-loaded formulations as a approach breast cancer. By analyzing available evidence, we aim determine benefits and limitations these in terms activity, bioavailability, safety. A systematic search relevant databases was conducted identify studies investigating context treatment. The inclusion criteria encompassed clinical trials, preclinical studies, in-vitro experiments that reported phytochemicals various Data extraction performed ensure reliability validity included studies. highlights diverse range used different Findings suggest exhibit promising effects by targeting multiple signaling pathways progression, including cell proliferation, apoptosis, angiogenesis, metastasis. Moreover, delivery systems, such nanoparticles, liposomes, micelles, enhanced phytochemicals' bioavailability targeted delivery. Phytochemical-loaded hold immense reviewed evidence indicates ability inhibit tumor growth, enhance chemotherapy effectiveness, reduce adverse effects. However, further research warranted optimize formulation strategies, investigate long-term safety profiles, conduct large-scale trials establish efficacy applicability settings. These findings contribute developing novel phytochemical-based therapies cancer, offering new avenues personalized treatment options.

Language: Английский

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Conjugated Nanoparticles for Solid Tumor Theranostics: Unraveling the Interplay of Known and Unknown Factors

ACS Omega, Journal Year: 2023, Volume and Issue: 8(41), P. 37654 - 37684

Published: Oct. 5, 2023

Cancer diagnoses have been increasing worldwide, and solid tumors are among the leading contributors to patient mortality, creating an enormous burden on global healthcare system. is responsible for around 10.3 million deaths worldwide. Solid one of most prevalent cancers observed in recent times. On other hand, early diagnosis a significant challenge that could save person's life. Treatment with existing methods has pitfalls limit successful elimination disorder. Though nanoparticle-based imaging therapeutics shown impact healthcare, current methodologies tumor treatment insufficient. There multiple complications associated management as well. Recently, surface-conjugated nanoparticles such lipid nanoparticles, metallic quantum dots positive results diagnostics preclinical models. Other nanotheranostic material platforms plasmonic theranostics, magnetotheranostics, hybrid nanotheranostics, graphene theranostics also explored. These nanoparticle ensure appropriate targeting along selective delivery cargos (both therapeutic probes) without affecting surrounding healthy tissues. they applications, still possess numerous limitations need be addressed order fully utilized clinic. In this review, we outline importance materials design strategies used engineer how effectively each method overcomes drawbacks techniques. We highlight gaps platform considerations can address their future research directions.

Language: Английский

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Oral cancer: Current and new drug delivery system

Elsevier eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 429 - 450

Published: Jan. 1, 2025

Language: Английский

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Chemotherapy-free innovations in locally advanced head and neck cancer: a comprehensive review

Frontiers in Oncology, Journal Year: 2025, Volume and Issue: 15

Published: April 22, 2025

The treatment of locally advanced head and neck squamous cell carcinoma (LA-HNSCC) has traditionally relied on a multimodal approach, combining surgery, radiation therapy (RT), chemotherapy. While chemotherapy plays critical role in improving cure rates functional outcomes, its substantial toxicity remains major concern, particularly older patients. These challenges are especially relevant for those who unfit or decline conventional concurrent chemoradiotherapy (CCRT), highlighting the need alternative therapeutic options. Many patients at high risk severe side effects, often preventing them from completing full regimen. This review explores strategies to definitive CCRT carcinomas larynx, hypopharynx oropharynx, aiming optimize outcomes while minimizing toxicity. We discuss altered fractionation as promising RT, offering balance between efficacy quality life. Additionally, we examine emerging approaches, including targeted therapies, immunotherapy, hyperthermia, photodynamic nanoparticle-based treatments with which provide complementary options traditional therapies management LA-HNSCC.

Language: Английский

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Aktuelle Entwicklungen der nanopartikelbasierten Tumortherapie bei Kopf-Hals-Tumoren

HNO, Journal Year: 2025, Volume and Issue: unknown

Published: May 19, 2025

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Nanoparticle Properties

Published: Feb. 16, 2024

As a constantly expanding class of materials with several applications, NPs have drawn enormous interest. They are being used at an accelerated rate in diverse fields like cosmetics, food industry, and electronics. In the sphere modern medicine too, become inevitable paradigm. Due to extremely high ratio atoms on their surface those inside particle, what known as quantum characteristics. properties shape, size, morphology diverge from bulk materials, catalytic characteristics improve so is applicability. Cellular interactions, behavior NPs, effects influenced by various charge most prominent. However, while opening new horizons, unique can also account for toxicity. Thus, it crucial understand NPs. The chapter focuses important interactions toxicity been discussed brief. addition, characterization techniques determining tabulated.

Language: Английский

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