Ferroptosis-related protein biomarkers for diagnosis, differential diagnosis, and short-term mortality in patients with sepsis in the intensive care unit

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: April 8, 2025

Background Sepsis is a disease with high mortality caused by dysregulated response to infection. Ferroptosis newly discovered type of cell death. Ferroptosis-related genes are involved in the occurrence and development sepsis. However, research on diagnostic value ferroptosis-related protein biomarkers sepsis serum limited. This study aims explore clinical proteins diagnosing predicting risk. Methods A single-center, prospective, observational was conducted from January December 2023, involving 170 patients, 49 non-septic ICU 50 healthy individuals. Upon admission, biochemical parameters, GCS, SOFA, APACHE II scores were recorded, surplus stored at -80°C for biomarker analysis via ELISA. Diagnostic efficacy evaluated using ROC curve analysis. Results Baseline levels ACSL4, GPX4, PTGS2, CL-11, IL-6, IL-8, PCT, hs-CRP significantly differed among sepsis, non-septic, individuals (all p - < 0.01). demonstrated differential performance (AUC: 0.6688 0.9945). IL-10 TNF-α showed good (AUC = 0.8955 0.7657, respectively). ACSL4 0.7127) associated mortality. Serum IL-6 above cut-off shorter survival times. positively correlated SOFA (Rho 0.354, 0.0001), 0.317, septic shock 0.274, 0.003) but negatively GCS score -0.218, 0.018). GPX4 0.204, 0.027) 0.233, 0.011) scores. Conclusion have strong including ability predict 28-day may become new potential markers

Language: Английский

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Regulation of Iron Metabolism in Ferroptosis: from Mechanism Research to Clinical Translation

Journal of Pharmaceutical Analysis, Journal Year: 2025, Volume and Issue: unknown, P. 101304 - 101304

Published: April 1, 2025

Language: Английский

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Luteolin alleviates estrogen deficiency-induced muscle atrophy via targeting SLC7A11-mediated ferroptosis

Phytomedicine, Journal Year: 2025, Volume and Issue: unknown, P. 156799 - 156799

Published: April 1, 2025

Language: Английский

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[Ferroptosis inducer Erastin inhibits proliferation of liver cancer cells

PubMed, Journal Year: 2024, Volume and Issue: 44(11), P. 2131 - 2136

Published: Nov. 20, 2024

To investigate the expression of Acyl-CoA synthetase long-chain family member 4 (ACSL4) in liver cancer and its role regulating ferroptosis proliferation cells.

Language: Английский

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