Nanomedicine in Immunotherapy for Non‐Small Cell Lung Cancer: Applications and Perspectives

Small Methods, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 28, 2025

Abstract Non‐small cell lung cancer (NSCLC) has a strikingly high incidence rate globally. Although immunotherapy brings great breakthrough in its clinical treatment of NSCLC, significant challenges still need to be overcome. The development novel multi‐functional nanomedicines the realm tumor offers promising opportunities for NSCLC patients, as exhibit advantages, including specific targeting cells, improved drug bioavailability, reduced systemic toxicity, and overcoming immune resistance. In this review, core features current status strategies checkpoint blockade, antibody–drug conjugates, engagers, adoptive vaccines, are surveyed. Particular emphasis is placed on recent that boost these strategies. Nanomedicine can provide perspectives immunotherapy.

Language: Английский

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Targeted codelivery of nitric oxide and hydrogen sulfide for enhanced antithrombosis efficacy

Bioactive Materials, Journal Year: 2025, Volume and Issue: 48, P. 29 - 42

Published: Feb. 13, 2025

Language: Английский

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Docetaxel-Loaded Electrospun Nanofibrous Mats for Local Chemotherapy Targeting Positive Surgical Margins in Prostate Cancer

Molecular Pharmaceutics, Journal Year: 2025, Volume and Issue: unknown

Published: March 12, 2025

Positive surgical margins following radical prostatectomy significantly contribute to tumor recurrence. While systemic chemotherapy demonstrates limited efficacy in this context, local drug delivery systems based on nanomaterials offer promising strategies address issue by modifying release kinetics and distribution, thereby enhancing antitumor effects while minimizing the toxicities associated with chemotherapy. In study, we utilized electrospun nanofibrous mats loaded docetaxel for sustained delivery. vitro experiments demonstrated that these implantable drug-loaded effectively inhibited prostate cancer cell growth, induced cycle arrest, promoted apoptosis. animal models, exhibited prominent therapeutic positive postoperatively. Importantly, docetaxel-loaded modulated immune microenvironment suppressing M2-like macrophages, increasing ratio between M1- CD8+ T-cell infiltration. Local administration reduced toxicity compared summary, developed an mat localized delivery, which offers a prospective strategy managing after surgery.

Language: Английский

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Machine Learning‐Driven Prediction, Preparation, and Evaluation of Functional Nanomedicines Via Drug–Drug Self‐Assembly

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 10, 2025

Abstract Small molecules as nanomedicine carriers offer advantages in drug loading and preparation. Selecting effective small for stable nanomedicines is challenging. This study used artificial intelligence (AI) to screen combinations self‐assembling nanomedicines, employing physiochemical parameters predict formation via machine learning. Non‐Steroidal Anti‐Inflammatory Drugs (NSAIDs) are identified antineoplastic drugs, with high loading. Nanomedicines, PEG‐coated indomethacin/paclitaxel (PiPTX), laminarin‐modified (LiDOX), developed extended circulation active targeting functions. Indomethacin/paclitaxel iDOX exhibits pH‐responsive release the tumor microenvironment. These enhance anti‐tumor effects reduce side effects, offering a rapid approach clinical development.

Language: Английский

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An ASGP-R-targeting magnetic resonance imaging contrast agent for liver cancer diagnosis

Journal of Materials Chemistry B, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

In this study, a novel ASGP-R targeted contrast agent has been developed for liver cancer diagnosis, which exhibits high imaging efficacy and great biosafety, holding promise as MRI of human cancer.

Language: Английский

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Tailoring the dendronized structures of cyclodextrin-based supramolecular nanoassemblies for enhanced tumor paraptosis via disrupting endoplasmic reticulum homeostasis

Acta Biomaterialia, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Language: Английский

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Application of Branched-Polyethyleneimine/Polyacrylic-Acid Self-assembled Nanocapsules Supported by Mesoporous Spherical Shell Structures in the Treatment of Multiple Myeloma

Colloids and Surfaces A Physicochemical and Engineering Aspects, Journal Year: 2025, Volume and Issue: unknown, P. 136461 - 136461

Published: Feb. 1, 2025

Language: Английский

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Topology‐Oriented Lymph Node Drainage of Dendritic Polymer‐TLR Agonist Conjugates to Enhance Vaccine Immunogenicity

Advanced Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 17, 2025

Strategically targeting lymph nodes (LNs) to orchestrate the initiation and regulation of adaptive immune responses is one most pressing challenges in context vaccination. Herein, a series polymer-TLR agonist conjugates (PTACs) developed investigate impact dendritic-topological characteristics on their LN activity vivo, molecular weight (MW) pharmacokinetics support homing. Notably, dendritic 6-arm PTAC with MW 60 kDa (6A-PTAC-60k) rapidly delivered cargo draining LNs after administration peripheral tissues. Specifically, this topologic structure ameliorated behavior within lymphatic vessels LNs, including an elevated amount TLR7/8 improved distribution pattern among barrier cells cells, increased permeability, prolonged retention. Furthermore, 6A-PTAC-60k formulation induced broad antibody T cell responses, enhancing vaccine immunogenicity suppressing tumor growth. The results revealed that both topology polymers are crucial factors for immunoadjuvant functional which, turn, enhanced formulation. This study may provide chemical structural basis optimizing design delivery systems.

Language: Английский

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The role of nanoparticle mechanical properties in drug delivery and cancer therapy

Precision medicine and engineering., Journal Year: 2025, Volume and Issue: unknown, P. 100020 - 100020

Published: Feb. 1, 2025

Language: Английский

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Novel Therapeutic Strategies and Recent Advances in Gut Microbiota Synergy with Nanotechnology for Colorectal Cancer Treatment

Materials Today Bio, Journal Year: 2025, Volume and Issue: 31, P. 101601 - 101601

Published: Feb. 20, 2025

Over the last two decades, molecular biology advances have revealed gut microbiota's active and crucial role in colorectal cancer (CRC) pathogenesis its dysregulation during tumorigenesis. This understanding has underscored urgency of exploring novel therapeutic approaches to address challenges posed by CRC. Among these approaches, nanosynergistic therapies, with their potential modulate microbiota, increase drug bioavailability stability, reduce side effects, emerged as a promising avenue. Furthermore, efficacy nanotechnology-based can be enhanced combining them different methods, including chemotherapy, radiotherapy, immunotherapy, photothermal therapy, sonodynamic therapy. Herein, recent progress nano synergistic therapy been reviewed, focusing on synergy between microbiota nanotechnology CRC treatment. Additionally, diverse applications nanoparticles analyzed provide innovative ideas effective solutions for developing highly treatment strategies.

Language: Английский

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