Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 493, P. 152697 - 152697
Published: June 5, 2024
Language: Английский
Frontiers in Immunology, Journal Year: 2021, Volume and Issue: 12
Published: Aug. 26, 2021
Pregnancy is a unique type of immunological process. Healthy pregnancy associated with series inflammatory events: implantation (inflammation), gestation (anti-inflammation), and parturition (inflammation). As the most abundant leukocytes during pregnancy, natural killer (NK) cells are recruited activated by ovarian hormones have pivotal roles throughout pregnancy. During first trimester, NK represent up to 50-70% decidua lymphocytes. Differently from peripheral-blood cells, decidual (dNK) poorly cytolytic, they release cytokines/chemokines that induce trophoblast invasion, tissue remodeling, embryonic development, placentation. can also shift cytotoxic identity carry out immune defense if infected in utero pathogens. At late gestation, premature activation lead breakdown tolerance maternal-fetal interface and, subsequently, result preterm birth. This review focused on role dNK normal pathological including preeclampsia, recurrent spontaneous abortion, endometriosis, failure. could be targets for treatment complications.
Language: Английский
Citations
143
Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14
Published: Feb. 14, 2023
Endometriosis, an estrogen-dependent chronic inflammatory disease characterized by the growth of endometrium-like tissues outside uterine cavity, affects 10% reproductive-age women. Although pathogenesis endometriosis is uncertain, it widely accepted that retrograde menstruation results in ectopic endometrial tissue implantation. Given not all women with develop endometriosis, immune factors have been hypothesized to affect endometriosis. In this review, we demonstrate peritoneal microenvironment, including innate immunity and adaptive immunity, plays a central role Current evidence supports fact cells, such as macrophages, natural killer (NK) dendritic cells (DCs), neutrophils, T B well cytokines mediators, contribute vascularization fibrogenesis endometriotic lesions, accelerating implantation development lesions. Endocrine system dysfunction influences microenvironment through overexpressed estrogen progesterone resistance. light limitations hormonal therapy, describe prospects for potential diagnostic biomarkers nonhormonal therapy based on regulation microenvironment. Further studies are warranted explore available immunological therapeutic strategies
Language: Английский
Citations
68
Autophagy, Journal Year: 2022, Volume and Issue: 18(10), P. 2459 - 2480
Published: Feb. 27, 2022
Massive infiltrated and enriched decidual macrophages (dMφ) have been widely regarded as important regulators of maternal-fetal immune tolerance trophoblast invasion, contributing to normal pregnancy. However, the characteristics metabolic profile underlying mechanism dMφ residence remain largely unknown. Here, we observe that display an active glycerophospholipid metabolism. The activation ENPP2-lysophosphatidic acid (LPA) facilitates adhesion retention, M2 differentiation during Mechanistically, this process is mediated through LPA receptors (LPAR1 PPARG/PPARγ)-DDIT4-macroautophagy/autophagy axis, further upregulation multiple factors (e.g., cadherins selectins) in a CLDN7 (claudin 7)-dependent manner. Additionally, poor invasion placenta development, high ratio embryo loss are observed Enpp2±, lpar1−/− or PPARG-blocked pregnant mice. Patients with unexplained spontaneous abortion insufficient autophagy cell dMφ. In therapeutic studies, supplementation inducer rapamycin significantly promotes residence, improves resorption Enpp2± mouse models, which should be dependent on DDIT4-autophagy-CLDN7-adhesion molecules axis. This observation reveals inactivation ENPP2-LPA metabolism result resident obstacle increase risk abortion, provides potential strategies prevent abortion.
Language: Английский
Citations
48
Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14
Published: April 25, 2023
Although estrogen is predominantly related to the maintenance of reproductive functioning in females, it mediates various physiological effects nearly all tissues, especially central nervous system. Clinical trials have revealed that estrogen, 17β-estradiol, can attenuate cerebral damage caused by an ischemic stroke. One mechanism underlying this effect 17β-estradiol modulating responses immune cells, indicating its utility as a novel therapeutic strategy for The present review summarizes sex on stroke progression, role immunomodulator reactions, and potential clinical value replacement therapy. data presented here will help better understand immunomodulatory function may provide basis use
Language: Английский
Citations
30
Reproductive Medicine and Biology, Journal Year: 2024, Volume and Issue: 23(1)
Published: Jan. 1, 2024
Abstract Background Endometriosis is a common gynecological condition, with symptoms including pain and infertility. Regurgitated endometrial cells into the peritoneal cavity encounter hypoxia nutrient starvation. Endometriotic have evolved various adaptive mechanisms to survive in this inevitable condition. These adaptations include escape from apoptosis. Autophagy, self‐degradation system, controls apoptosis during stress conditions. However, date, regulating interplay between autophagy are still poorly understood. In review, we summarize current understanding of molecular characteristics endometriosis discuss future therapeutic challenges. Methods A search PubMed Google Scholar databases were used identify relevant studies for narrative literature review. Results Autophagy may be dynamically regulated through intrinsic (e.g., PI3K/AKT/mTOR signal transduction network) extrinsic iron‐mediated oxidative stress) pathways, contributing development progression endometriosis. Upregulation mTOR expression suppresses via inhibiting pathway, whereas or excess iron often inhibits promoting autophagy. Conclusion acquired antiapoptotic unique pathways changing environments.
Language: Английский
Citations
12
Diagnostics, Journal Year: 2025, Volume and Issue: 15(5), P. 548 - 548
Published: Feb. 24, 2025
Endometriosis is a chronic, inflammatory condition where endometrial-like tissue grows outside the uterus, affecting around 10% of women reproductive age. This associated with debilitating symptoms, including dysmenorrhea, dyspareunia, chronic pelvic pain, fatigue, and infertility. Adolescents endometriosis face unique challenges, as disease often misdiagnosed or undiagnosed for an average 7-10 years due to its complex multifactorial nature. Consequently, patients frequently suffer from worsening symptoms significant psychological distress, anxiety, depression, social withdrawal. While there no definitive cure endometriosis, treatment approaches typically involve hormonal therapies, lifestyle adjustments (such diet exercise), support. Recent studies emphasize profound impact on mental health adolescents, highlighting need more holistic approach that integrates both medical care. narrative review explores psychosocial effects in examining biological mechanisms linking outcomes. It also discusses current therapeutic strategies, such cognitive behavioral therapy, mindfulness, peer support, underscores importance early diagnosis multidisciplinary care mitigate physical emotional burdens condition. integrated critical improving overall well-being quality life adolescents living endometriosis.
Language: Английский
Citations
1
International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(5), P. 2071 - 2071
Published: Feb. 27, 2025
Nanoplastics (NPs) represent a major challenge in environmental contamination resulting from the physical, chemical, and biological degradation of plastics. Their characterization requires advanced expensive methods, which limit routine analyses. The effects NPs depend on their chemical physical properties, influence toxicity interactions with systems. Studies animal models, such as Daphnia magna Danio rerio, show that induce oxidative stress, inflammation, DNA damage, metabolic alterations, often related to charge particle size. affect endocrine functions by acting disruptors, interfering thyroid sex hormones showing potential transgenerational through epigenetic modifications, including hyper- hypomethylation. Behavioral neurofunctional alterations have been observed rerio mouse suggesting link between NP exposure neurotransmitters dopamine serotonin. Despite limited human studies, presence breast milk placenta underscores need for further investigation health effects. Research focusing genetic markers is encouraged elucidate molecular mechanisms risks associated chronic exposure.
Language: Английский
Citations
1
Cell Death Discovery, Journal Year: 2023, Volume and Issue: 9(1)
Published: Aug. 22, 2023
Abstract Endometriosis is strongly associated with infertility. Several mechanisms have been reported in an attempt to elucidate the pathophysiological effects that lead reduced fertility women endometriosis. However, by which endometriosis affects not fully elucidated. Ferroptosis a novel form of nonapoptotic cell death characterized iron-dependent lipid peroxidation membrane damage. In past reports, elevated iron levels ectopic lesions, peritoneal fluid and follicular patients The high-iron environment closely ferroptosis, appears exhibit double-edged effect on can cause damage ovarian granulosa cells, oocytes, embryos, leading endometriosis-related This article summarizes main pathways regulatory ferroptosis explores possible formation iron-overloaded endometriotic fluid. Finally, we reviewed recent studies potential
Language: Английский
Citations
19
International Journal of Molecular Sciences, Journal Year: 2021, Volume and Issue: 22(10), P. 5074 - 5074
Published: May 11, 2021
Endometriosis is a gynecological condition affecting patients in reproductive age. The aim of this paper was to assess the effects autophagy and mitophagy induction rat model endometriosis. induced by injection uterine fragments, rapamycin (0. 5 mg/kg) administered once per week. One week from induction, rats were sacrificed, laparotomy performed collect endometriotic implants further process them for molecular analysis. Western blot analysis conducted on explanted lesions evaluate pathway during pathology. Elevated phospho-serine/threonine kinase (p-AKT) mammalian target (mTOR) expressions detected vehicle-treated rats, while Beclin microtubule-associated protein 1A/1B-light chain 3 II (LC3II) low. Additionally, samples collected vehicle groups indicated low Bnip3, Ambra1, Parkin expressions, demonstrating impaired mitophagy. Rapamycin administration reduced p-AKT mTOR increased LC3II, activating both mechanisms. We also evaluated impact pathways apoptosis angiogenesis. mitophagy, which (assessed Bcl-2, Bax, Cleaved-caspase 3) angiogenesis immunohistochemical vascular endothelial grow factor (VEGF) CD34) lesions. All these mechanisms activated led reduction lesions' volume, area diameter.
Language: Английский
Citations
41
International Journal of Biological Sciences, Journal Year: 2022, Volume and Issue: 18(3), P. 1150 - 1170
Published: Jan. 1, 2022
In some cases of spontaneous miscarriage (SM), the exact etiology cannot be determined. Autophagy, which is responsible for cellular survival under stress conditions, has also been implicated in many diseases. Recently, it surmised to correlated with SM. However, detailed mechanism remains elusive. fact, there are several essential steps during pregnancy establishment and maintenance: trophoblasts invasion, placentation, decidualization, enrichment infiltration decidua immune cells (e.g., natural killer, macrophage T cells). Accordingly, upstream molecules downstream effects autophagy discussed these processes, respectively. Of note, regulates crosstalk between at maternal-fetal interface as well. Aberrant found villi, decidual stromal cells, peripheral blood mononuclear SM patients, although findings inconsistent among different studies. Furthermore, potential treatments targeting included, rapamycin vitamin D hot-spots recent literatures. To conclude, a moderately activated deeply involved pregnancy, suggesting that should regulator promising target treating
Language: Английский
Citations
24