BioNanoScience, Journal Year: 2024, Volume and Issue: 15(1)
Published: Dec. 18, 2024
Language: Английский
Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 510, P. 215842 - 215842
Published: April 15, 2024
Language: Английский
Citations
17
European Journal of Medicinal Chemistry Reports, Journal Year: 2025, Volume and Issue: unknown, P. 100268 - 100268
Published: April 1, 2025
Language: Английский
Citations
1
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(24), P. 13302 - 13302
Published: Dec. 11, 2024
This review aims to address the significant challenges of treating central nervous system (CNS) disorders such as neurodegenerative diseases, strokes, spinal cord injuries, and brain tumors. These are difficult manage due complexity disease mechanisms protective blood–brain barrier (BBB), which restricts drug delivery. Recent advancements in nanoparticle (NP) technologies offer promising solutions, with potential applications delivery, neuroprotection, neuroregeneration. By examining current research, we explore how NPs can cross BBB, deliver medications directly targeted CNS regions, enhance both diagnostics treatment. Key NP strategies, passive targeting, receptor-mediated transport, stimuli-responsive systems, demonstrate encouraging results. Studies show that may improve minimize side effects, increase therapeutic effectiveness models Alzheimer’s, Parkinson’s, stroke, glioblastoma. thus represent a approach for disorder management, combining delivery diagnostic capabilities enable more precise effective treatments could significantly benefit patient outcomes.
Language: Английский
Citations
5
Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(7), P. 1848 - 1848
Published: June 29, 2023
Cathepsin B is a lysosomal cysteine protease, contributing to vital cellular homeostatic processes including protein turnover, macroautophagy of damaged organelles, antigen presentation, and in the extracellular space, it takes part tissue remodeling, prohormone processing, activation. However, aberrant overexpression cathepsin its enzymatic activity associated with different pathological conditions, cancer. tumor tissues makes this enzyme an important target for smart delivery systems, responsive enzyme. The generation technologies which therapeutic effect activated as result cleavage provides opportunity tumor-targeted therapy controlled drug release. In review, we summarized designed improve current cancer treatments that were shown play key role disease progression response treatment.
Language: Английский
Citations
13
Molecular Pharmaceutics, Journal Year: 2024, Volume and Issue: 21(3), P. 1382 - 1389
Published: Feb. 19, 2024
Cathepsin B, a lysosomal protease, is considered as crucial biomarker for tumor diagnosis and treatment it overexpressed in numerous cancers. A stimulus-responsive SF scaffold has been reported to detect the activity of variety tumor-associated enzymes. In this work, small-molecule PET tracer ([68Ga]NOTA-SF-CV) was developed by combining an with cathepsin B-specific recognition substrate Cit-Val. Upon activation [68Ga]NOTA-SF-CV could form cyclization product reduction environment, resulting reduced hydrophilicity. This unique property effectively prevent exocytosis B-overexpressing cells, leading prolonged retention amplified imaging signal. Moreover, had great targeting specificity B. vivo microPET results showed that able visualize expression level B various tumors. Hence, may be served potential diagnosing B-related diseases.
Language: Английский
Citations
4
Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)
Published: April 19, 2025
Language: Английский
Citations
0
Nanomedicine, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 17
Published: May 12, 2025
Glioblastoma (GBM) poses a formidable challenge because of its high morbidity and mortality. The therapeutic efficacy GBM is significantly hampered by the intricate blood-brain barrier (BBB) tumor (BBTB). Nanomaterial-based brain-targeted delivery systems have shown great potential for effectively delivering agents treatment overcoming limitations conventional drugs, such as poor BBB penetration, short half-life, low bioavailability. This review focuses on an in-depth analysis interplay between BBB/BBTB drug transport kinetics while analyzing innovative nanoparticle-mediated strategies enhanced treatment. Moreover, nanoparticle-based are emphasized, with particular attention given to biomimetic nanoparticles (BMNPs), whose unique advantages. current challenges, translational potential, future research directions in this rapidly evolving field comprehensively discussed, highlighting advances nanomaterial applications. aims stimulate further into systems, offering promising avenues maximizing effects gene drugs or chemotherapeutic practical
Language: Английский
Citations
0
International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 144324 - 144324
Published: May 1, 2025
Language: Английский
Citations
0
Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(10), P. 2422 - 2422
Published: Oct. 4, 2023
Human glioblastoma multiforme (GBM) is a primary malignant brain tumor, radically incurable disease characterized by rapid growth resistance to classical therapies, with median patient survival of about 15 months. For decades, plethora approaches have been developed make GBM therapy more precise and improve the diagnosis this pathology. Targeted delivery mediated use various molecules (monoclonal antibodies, ligands overexpressed tumor receptors) one promising methods achieve goal. Here we present novel genetically encoded nanoscale dual-labeled system based on Quasibacillus thermotolerans (Qt) encapsulins exploiting biologically inspired designs iron-containing nanoparticles as cargo, conjugated human fluorescent labeled transferrin (Tf) acting vector. It known that expression receptors (TfR) in glioma cells significantly higher compared non-tumor cells, which enables targeting resulting nanocarrier. The selectivity binding obtained nanosystem was studied qualitative quantitative assessment accumulation intracellular iron, well magnetic particle quantification method laser scanning confocal microscopy. Used unambiguously demonstrated transferrin-conjugated were captured much efficiently than benign cells. bioinspired nanoplatform can be supplemented chemotherapeutic drug or genotherapeutic agent used for targeted therapeutic Additionally, observed cell-assisted biosynthesis could an attractive way narrow size distribution particles applications.
Language: Английский
Citations
4
Journal of Science Advanced Materials and Devices, Journal Year: 2024, Volume and Issue: 9(2), P. 100718 - 100718
Published: April 16, 2024
The lack of effective diagnostic and therapeutic techniques is a crucial cause the high clinical mortality for malignancy. Notably, self-propelled micro/nanomotors are expected to address drawbacks by conventional nanoparticles in tumor diagnosis therapy. special locomotion property ensures efficiency on rapid distribution, deep penetration targeting delivery. Hence, this review, motion mechanism controllability speed direction were described, as well advantages regarding enhancement biological barrier crossing (overcoming blood flow obstacles, microenvironment barriers), delivery tumor. most recent advances micro/nanomotor contributions comprehensively summarized various medical imaging technologies, biosensing techniques, approaches, especially combination therapy integration treatment based multifunctional micro/nanomotors. Furthermore, challenges developing practical discussed along with future directions from clinicians' perspective, which promised up translation process contribute efficient
Language: Английский
Citations
1