Silver-quercetin-loaded honeycomb-like Ti-based interface combats infection-triggered excessive inflammation via specific bactericidal and macrophage reprogramming

Bioactive Materials, Journal Year: 2024, Volume and Issue: 43, P. 48 - 66

Published: Sept. 17, 2024

Language: Английский

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Biomimetic MicroRNAs‐Selenium‐Nanocomposites for Targeted and Combined Hyperlipidemia Therapy

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(16)

Published: March 8, 2024

Hyperlipidemia is considered as a high-risk factor for leading to coronary heart disease. MicroRNA-148a-3p (miR-148a-3p) inhibitor potential therapeutic target bind low-density lipoprotein cholesterol receptors (LDLR) decreasing the levels of in plasma. However, effects are not ideal clinical translation nucleic acids treatment, owing short circulation time vivo. Therefore, platelet membrane (PM) cloaks Se nanoparticles (SeNPs) delivery system with chitosan (CS) modifies and miR-148a-3p inhibitors encapsulated designed (PM/CS-SeNPs/miR). The PM/CS-SeNPs/miR shows uniform shell-core structure particle size ≈90 nm. Co-delivering effectively alleviate hyperlipidemia via LDLR pathway Toll-Like Receptor 4 (TLR-4)/NF-κB signaling pathway, respectively. Furthermore, coated by PM, successfully prolong 48 h vivo quickly liver no toxicity. This dual combination therapy miRNAs based on targeted presents high-performance strategy precise treatment.

Language: Английский

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Chitosan-Based Biomaterials for Hemostatic Applications: A Review on Recent Advances

Published: May 22, 2023

Hemorrhage is a detrimental event present in traumatic injury, surgery, and disorders of bleeding, that can become life-threatening if not properly managed. Moreover, uncontrolled bleeding complicate surgical interventions, altering the outcome procedures. Therefore, to reduce risk complications decrease morbidity mortality associated with hemorrhage, it necessary use an effective hemostatic agent ensures immediate control bleeding. In recent years, there have been increasingly rapid advances developing novel generation biomaterials properties. Nowadays, wide array topical agents available, including chitosan-based shown outstanding properties such as: antibacterial, antifungal, hemostatic, analgesic activity, addition their biocompatibility, biodegradability, wound-healing effects. This review provides analysis discusses progress made performance, mechanism action, efficacy, cost, safety years.

Language: Английский

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The hierarchical porous structures of diatom biosilica-based hemostat: From selective adsorption to rapid hemostasis

Journal of Colloid and Interface Science, Journal Year: 2023, Volume and Issue: 651, P. 544 - 557

Published: July 31, 2023

Language: Английский

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3D Electrospun nanofiber sponges of insect chitosan/pullulan/citric acid embedded with ZnMOF in situ for enhanced healing of MRSA-infected wounds

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 498, P. 155388 - 155388

Published: Sept. 1, 2024

Language: Английский

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