Role of liposomes in chemoimmunotherapy of Breast cancer DOI

Fatemeh Attarian,

Ghazaleh Hatamian,

Shamim Nosrati

et al.

Journal of drug targeting, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 43

Published: Feb. 19, 2025

In the dynamic arena of cancer therapeutics, chemoimmunotherapy has shown tremendous promise, especially for aggressive forms breast like triple-negative (TNBC). This review delves into significant role liposomes in enhancing effectiveness by leveraging cancer-specific mechanisms such as induction immunogenic cell death (ICD), reprogramming tumor microenvironment (TME), and enabling sequential drug release. We examine innovative dual-targeting that capitalize on heterogeneity, well pH-sensitive formulations offer improved control over delivery. Unlike prior analyses, this directly links advancements preclinical research-such PAMAM dendrimer-based nanoplatforms RGD-decorated liposomes-to clinical trial results, highlighting their potential to revolutionize TNBC treatment strategies. Additionally, we address ongoing challenges related scalability, toxicity, regulatory compliance, propose future directions personalized, immune-focused nanomedicine. work not only synthesizes latest research but also offers a framework translating liposomal from laboratory practice.

Language: Английский

Mechanisms of immune checkpoint inhibitors: insights into the regulation of circular RNAS involved in cancer hallmarks DOI Creative Commons
Lingjiao Meng,

Haotian Wu,

Jiaxiang Wu

et al.

Cell Death and Disease, Journal Year: 2024, Volume and Issue: 15(1)

Published: Jan. 4, 2024

Abstract Current treatment strategies for cancer, especially advanced are limited and unsatisfactory. One of the most substantial advances in cancer therapy, last decades, was discovery a new layer immunotherapy approach, immune checkpoint inhibitors (ICIs), which can specifically activate cells by targeting checkpoints. Immune checkpoints type immunosuppressive molecules expressed on cells, regulate degree activation avoid autoimmune responses. ICIs, such as anti-PD-1/PD-L1 drugs, has shown inspiring efficacy broad applicability across various cancers. Unfortunately, not all patients benefit remarkably from overall response rates to ICIs remain relatively low types. Moreover, primary acquired resistance pose serious challenges clinical application immunotherapy. Thus, deeper understanding molecular biological properties regulatory mechanisms is urgently needed improve options fo r current therapies. Recently, circular RNAs (circRNAs) have attracted increasing attention, only due their involvement aspects hallmarks, but also impact shaping tumor microenvironment. In this review, we systematically summarize status existing roles circRNAs Meanwhile, aim settle issue an evidence-oriented manner that involved hallmarks effects

Language: Английский

Citations

59
Mitochondrial Disruption Nanosystem Simultaneously Depressed Programmed Death Ligand-1 and Transforming Growth Factor-β to Overcome Photodynamic Immunotherapy Resistance DOI
Xin Jiang, Yi Lei, Cheng Li

et al.

ACS Nano, Journal Year: 2024, Volume and Issue: 18(4), P. 3331 - 3348

Published: Jan. 16, 2024

Currently, limited photosensitizers possess the capacity to reverse tumor hypoxia and reduce programmed death ligand-1 (PD-L1) transforming growth factor-β (TGF-β) expression simultaneously, hindering perfect photodynamic therapy (PDT) effect due acquired immune resistance hypoxic microenvironment. To tackle these challenges, in this research, we demonstrated that mitochondrial energy metabolism depression can be utilized as an innovative efficient approach for reducing of PD-L1 TGF-β which may offer a design strategy more ideal PDT nanosystem. Through proteomic analysis 5637 cells, revealed tamoxifen (TMX) incredibly regulate cells. Then, selectively deliver clinically used depressant TMX solid tumors well nanosystem, synthesized MHI-TMX@ALB by combining mitochondria-targeted heptamethine cyanine PDT-dye MHI with through self-assembly albumin (ALB). Interestingly enough, nanoparticle effective reversion inhibition protein at lower dosage (7.5 times TMX), then enhanced efficacy immunotherapy via enhancing T-cell infiltration. Apart from this, leveraging dye's targeting toward TMX's role suppressing TGF-β, also effectively mitigated 4T1 lung metastasis development. All all, could multifunctional economical codepression immune-regulating strategy, broadening potential clinical applications

Language: Английский

Citations

17
The therapeutic potential of PD-1/PD-L1 pathway on immune-related diseases: Based on the innate and adaptive immune components DOI Open Access
Peng Zhang,

Yuting Wang,

Qianru Miao

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2023, Volume and Issue: 167, P. 115569 - 115569

Published: Sept. 26, 2023

Currently, immunotherapy targeting programmed cell death 1 (PD-1) or ligand (PD-L1) has revolutionized the treatment strategy of human cancer patients. Meanwhile, PD-1/PD-L1 pathway also been implicated in pathogenesis many immune-related diseases, such as autoimmune chronic infection diseases and adverse pregnancy outcomes, by regulating components innate adaptive immune systems. Given power new therapy, a better understanding regulatory effects on responses will facilitate discovery novel biomarkers therapeutic drug targets. Targeting this may successfully halt potentially even reverse these pathological processes. In review, we discuss recent major advances axis diseases. We reveal that impact system is complex manifold multi-strategies targeted are taken Consequently, pathway, alone combination with other treatments, represent for future intervention

Language: Английский

Citations

23
Enhancing cancer immunotherapy with photodynamic therapy and nanoparticle: making tumor microenvironment hotter to make immunotherapeutic work better DOI Creative Commons

Jayalakshmi Thiruppathi,

Veena Vijayan, In‐Kyu Park

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: April 5, 2024

Cancer immunotherapy has made tremendous advancements in treating various malignancies. The biggest hurdle to successful would be the immunosuppressive tumor microenvironment (TME) and low immunogenicity of cancer cells. To make successful, ‘cold’ TME must converted ‘hot’ immunostimulatory status activate residual host immune responses. this end, equilibrium should broken, immunogenic cell death ought induced stimulate tumor-killing cells appropriately. Photodynamic therapy (PDT) is an efficient way inducing (ICD) disrupting immune-restrictive tissues. PDT trigger a chain reaction that have ICD-induced antigens presented In principle, strategic combination synergize enhance therapeutic outcomes many intractable tumors. Novel technologies employing nanocarriers were developed deliver photosensitizers immunotherapeutic efficiently. New-generation nanomedicines been for recent years, which will accelerate clinical applications.

Language: Английский

Citations

12
A NRF2 Regulated and the Immunosuppressive Microenvironment Reversed Nanoplatform for Cholangiocarcinoma Photodynamic‐Gas Therapy DOI Creative Commons
Wang Wei-min, Yang Gao, Jianjun Xu

et al.

Advanced Science, Journal Year: 2024, Volume and Issue: 11(14)

Published: Feb. 2, 2024

Abstract Photodynamic therapy (PDT) is a minimally invasive and controllable local cancer treatment for cholangiocarcinoma (CCA). However, the efficacy of PDT hindered by intratumoral hypoxia presence an antioxidant microenvironment. To address these limitations, combining with gas may be promising strategy to enhance tumor oxygenation. Moreover, augmentation oxidative damage induced can achieved inhibiting NRF2, core regulatory molecule involved in response. In this study, integrated nanotherapeutic platform called CMArg@Lip, incorporating therapies using ROS‐responsive liposomes encapsulating photosensitizer Ce6, NO gas‐generating agent L‐arginine, NRF2 inhibitor ML385, successfully developed. The utilization CMArg@Lip effectively deals challenges posed microenvironment, resulting elevated levels subsequent induction ferroptosis CCA. Additionally, findings suggest that exhibits notable immunomodulatory effects, including promotion immunogenic cell death facilitation dendritic maturation. Furthermore, it contributes anti‐tumor function cytotoxic T lymphocytes through downregulation PD‐L1 expression cells activation STING signaling pathway myeloid‐derived suppressor cells, thereby reprogramming immunosuppressive microenvironment via various mechanisms.

Language: Английский

Citations

11
Advances in Nanodelivery Systems Based on Metabolism Reprogramming Strategies for Enhanced Tumor Therapy DOI
Zongquan Zhang, Xiaoya Liang, Xi Yang

et al.

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(6), P. 6689 - 6708

Published: Feb. 1, 2024

Tumor development and metastasis are closely related to the complexity of metabolism network. Recently, reprogramming strategies have attracted much attention in tumor therapy. Although there is preliminary success therapy agents, their therapeutic effects been restricted by effective reaching sites drugs. Nanodelivery systems with unique physical properties elaborate designs can specifically deliver tumors. In this review, we first summarize research progress nanodelivery based on enhance therapies depleting glucose, inhibiting glycolysis, lactic acid, lipid metabolism, glutamine glutathione, disrupting metal metabolisms combined other therapies, including chemotherapy, radiotherapy, photodynamic therapy, etc. We further discuss detail advantages for As well as opportunities challenges integrating into analyze outlook these emerging areas. This review expected improve our understanding modulating enhanced

Language: Английский

Citations

8
Fucoidan alleviates doxorubicin-induced cardiotoxicity by inhibiting ferroptosis via Nrf2/GPX4 pathway DOI
Yizhi Wang,

Jiawen Han,

Shifang Zhan

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 276, P. 133792 - 133792

Published: July 9, 2024

Language: Английский

Citations

8
Cyanine dyes in the mitochondria-targeting photodynamic and photothermal therapy DOI Creative Commons
Zdeněk Kejík, Jan Hajduch, Nikita Abramenko

et al.

Communications Chemistry, Journal Year: 2024, Volume and Issue: 7(1)

Published: Aug. 13, 2024

Abstract Mitochondrial dysregulation plays a significant role in the carcinogenesis. On other hand, its destabilization strongly represses viability and metastatic potential of cancer cells. Photodynamic photothermal therapies (PDT PTT) target mitochondria effectively, providing innovative non-invasive anticancer therapeutic modalities. Cyanine dyes, with strong mitochondrial selectivity, show enhancing PDT PTT. The limitations cyanine dyes for PTT are discussed, along their applications combination therapies, theranostic techniques, optimal delivery systems. Additionally, novel approaches sonodynamic therapy using photoactive presented, highlighting advances treatment.

Language: Английский

Citations

8
A comprehensive review of immune checkpoint inhibitors for cancer treatment DOI
Md Aslam Hossain

International Immunopharmacology, Journal Year: 2024, Volume and Issue: 143, P. 113365 - 113365

Published: Oct. 23, 2024

Language: Английский

Citations

8
Cell-Penetrating Peptide Like Anti-Programmed Cell Death-Ligand 1 Peptide Conjugate-Based Self-Assembled Nanoparticles for Immunogenic Photodynamic Therapy DOI

Jun-Hyuck Lee,

Seong-Bin Yang,

Seong Jin Park

et al.

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 6, 2025

The tumor-specific efficacy of the most current anticancer therapeutic agents, including antibody-drug conjugates (ADCs), oligonucleotides, and photosensitizers, is constrained by limitations such as poor cell penetration low drug delivery. In this study, we addressed these challenges developing, a positively charged, amphiphilic Chlorin e6 (Ce6)-conjugated, cell-penetrating anti-PD-L1 peptide nanomedicine (CPPD1) with enhanced tissue permeability. CPPD1 molecule, bioconjugate hydrophobic photosensitizer strongly charged programmed death-ligand 1 (PD-L1) binding (CPP), capable self-assembling into nanoparticles an average size 199 nm in aqueous solution without need for any carriers. These carrier-free possess ability to penetrate membrane cancer cells target tumors expressing PD-L1 on their surface. Notably, effectively blocked death-1 (PD-1)/PD-L1 interactions reduced expression via lysosomal degradation. They also demonstrated responsiveness photodynamic therapy (PDT) 635 laser, leading generation ROS, induction various immunogenic deaths (ICD). Highly penetrating could immunogenically modulate microenvironment CT26 were effective treating abscopal metastatic tumors, addressing major traditional PDT.

Language: Английский

Citations

1