Biosensors,
Journal Year:
2023,
Volume and Issue:
13(11), P. 968 - 968
Published: Nov. 6, 2023
A
powerful
and
accurate
method
for
identifying
isolating
cells
would
be
of
great
importance
due
to
its
sensitivity,
gentleness
effectiveness.
Here,
we
designed
a
receptor-based
DNA
logic
device
that
allows
Boolean
analysis
multiple
cells.
For
ease
expression,
the
molecules
on
cell
surface
can
bind
aptamer
are
referred
as
"receptors".
This
sends
signals
based
sgc8c
sgc4f
receptor
expression
by
performing
NOT,
NOR,
AND
OR
operations,
amplifies
evaluates
using
HCR.
Meanwhile,
release
ICG
from
endopore
HMSNs
is
controlled
affecting
structural
changes
in
device.
approach
accurately
identify
treat
demand
presence
or
absence
cell-specific
receptors,
facilitating
development
personalized
medicine.
ACS Sensors,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 5, 2025
Bladder
cancer
diagnosis
typically
involves
approaches
such
as
cystoscopy,
biopsy,
urine
cytology,
and
medical
imaging.
However,
these
invasive
procedures
carry
a
risk
of
complications,
direct
in
vitro
detection
on
clinical
samples
often
results
low
sensitivity.
Therefore,
this
study
proposed
urease-driven
magnetic
nanomotors
for
the
simultaneous
bladder
biomarkers
miRNA-21
miRNA-182
samples,
aiming
noninvasive
diagnosis.
The
nanomotor
was
constructed
from
gold
nanorods,
mesoporous
organo-silica,
Fe3O4,
hairpin
DNA
(hDNA),
functioning
recognition
probe
target
miRNAs.
In
urea
solution,
urease
catalyzed
into
ammonia
carbon
dioxide,
propelling
about
60
min,
which
enhanced
capacity
probes
to
capture
Subsequently,
enrichment
enabled
highly
sensitive
dual-miRNA
analysis,
allowing
quantification
with
limits
29
362
fM,
respectively.
nanoprobes
also
effectively
detected
miRNAs
spiked
samples.
This
multiple
increased
reliability
diagnosis,
presenting
novel
strategy
through
precise
analysis
actual
ACS Applied Nano Materials,
Journal Year:
2023,
Volume and Issue:
6(19), P. 17626 - 17636
Published: Sept. 14, 2023
A
bispecific
thermosensitive
system
was
created
to
deliver
drugs
and
aid
T
cells
in
identifying
cancer
for
enhancing
the
tumor-killing
effect.
Among
various
nanocarriers,
gold
nanocages
(AuNCs)
were
selected
as
photothermal
agents
therapy
(PTT)
due
their
distinctive
hollow
void
structures,
which
make
them
ideal
carriers
throughout
therapy.
To
achieve
controlled
drug
release
under
near-infrared
radiation,
lauric
acid
(LA)
chosen
"gatekeeper",
responding
a
temperature
stimulus.
Bispecific
aptamers
with
surface
modifications
utilized
increase
intracellular
content
while
triggering
immune
eliminate
cells.
The
homologous
targeting
ability
of
AuNCs/LA/
doxorubicin
(DOX)/Apt
resulted
high
tumor
site
aggregation.
PTT-induced
situ
heat
elimination
increased
cell
immunogenicity
upon
exposure
laser
irradiation.
Consequently,
smart
nano
platform
not
only
destroyed
through
PTT
chemotherapy
but
also
formed
cell–cancer
complex
at
site,
causing
precisely
identify
activation
response
site.
proposed
strategy
classic
"cocktail
therapy".
Deleted Journal,
Journal Year:
2024,
Volume and Issue:
1(2), P. 124 - 137
Published: June 1, 2024
Reactive
Oxygen
Species
(ROS)
therapy
based
on
metal
ion
catalysis
had
attracted
much
attention
due
to
its
high
selectivity
for
tumour
cells
and
lower
side
effects.
Copper
ions
(Cu2+)
show
great
potential
in
their
efficient
fenton-like
catalysis.
However,
the
accumulation
utilisation
efficiency
of
copper
within
cell
was
limited,
hence
need
delivery
Cu2+
into
cell.
Curcumin
(CUR)
not
only
acted
as
a
ligand
bind
ions,
but
also
an
electron
donor
increase
catalytic
Cu+
enhance
generation
ROS.
Calcium
carbonate
(CaCO3)
nanoparticles
good
biocompatibility,
alleviated
microacidic
environment
tumours
released
calcium
(Ca2+)
trigger
overload
leading
apoptosis.
Therefore,
present
study,
CaCO3
(CRC@lip)
loaded
with
curcumin
were
designed
modified
liposomal
surface
improve
stability
dispersion
vivo.
CRC@lip
generated
higher
activity
by
releasing
Cu2+,
reacting
glutathione
(GSH).
catalyzed
highly
toxic
·OH
radicals
H2O2,
while
property
CUR
further
enhanced
dispersal
nanoparticles.
The
electron-donor
effect
amplified
killing
through
interaction
This
strategy
improved
therapeutic
effect,
may
reduce
effects
traditional
chemotherapeutic
drugs,
providing
new
way
thinking
cancer
treatment.
ACS Materials Letters,
Journal Year:
2024,
Volume and Issue:
unknown, P. 5354 - 5362
Published: Nov. 6, 2024
Androgenic
alopecia
(AGA)
is
a
prevalent
progressive
hair
loss
condition.
The
main
therapeutic
drug,
minoxidil,
limited
by
its
poor
efficacy
and
side
effects
such
as
contact
dermatitis
hypertrichosis.
Nitric
oxide
(NO),
an
endothelial-derived
relaxing
factor,
promotes
angiogenesis
accelerates
blood
flow,
enhancing
nutrient
supply
similar
to
minoxidil.
Accordingly,
we
utilized
poly(vinyl
alcohol)
film
(PVA)
loaded
with
hyaluronic
acid
(HA)
liposomes
construct
multistage
transdermal
NO
delivery
system
(PVA@HL/NONOate)
for
the
treatment
of
AGA.
HA
provided
efficient
loading
extended
release,
while
PVA
improved
skin
penetration
sustained
increasing
bioavailability.
Low-concentration
effectively
enhanced
follicle
vitality
repaired
vessels.
Mechanistically,
low-concentration
could
treat
AGA
mainly
regulating
HIF-1
signaling
pathway
promote
angiogenesis,
reducing
inflammation
downregulating
expression
TNFRSF9
IL-6,
repairing
follicles
genes
in
CXCL5-IL-17
inflammatory
axis.
