A Milk Extracellular Vesicle‐Based Nanoplatform Enhances Combination Therapy Against Multidrug‐Resistant Bacterial Infections DOI Creative Commons
Shaoqi Qu, Shuo Yang, Qingjun Xu

et al.

Advanced Science, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 25, 2024

Abstract The increasing occurrence of infections caused by multidrug‐resistant (MDR) bacteria drives the need for new antibacterial drugs. Due to current lack antibiotic discovery and development, strategies fight MDR are urgently needed. Efforts develop adjuvants increase effectiveness existing antibiotics design delivery systems essential address this issue. Here, a bioinspired system equipped with combination therapy paracellular transport is shown enhance efficacy against bacterial improving oral delivery. A screening platform established using an in vitro‐induced high polymyxin‐resistant strain acquire plumbagin, which enhances polymyxin. Functionalized milk extracellular vesicles (FMEVs) coloaded polymyxin plumbagin cleared 99% within 4 h. Mechanistic studies revealed that drug damaged membrane, disrupted energy metabolism, accelerated death. Finally, FMEVs efficiently transported transcellularly through citric acid‐mediated reversible opening tight junctions showed Escherichia coli ‐associated peritonitis–sepsis model mice. These findings provide potential therapeutic strategy improve enhancing biomimetic platform.

Language: Английский

Incorporation of cetylpyridinium/Cu2+/montmorillonite material into TPU for the construction of synergistic antibacterial membrane DOI

Xiaoyu Zhang,

Chunquan Li, Fang Yuan

et al.

Applied Materials Today, Journal Year: 2024, Volume and Issue: 42, P. 102545 - 102545

Published: Dec. 7, 2024

Language: Английский

Citations

0
A Milk Extracellular Vesicle‐Based Nanoplatform Enhances Combination Therapy Against Multidrug‐Resistant Bacterial Infections DOI Creative Commons
Shaoqi Qu, Shuo Yang, Qingjun Xu

et al.

Advanced Science, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 25, 2024

Abstract The increasing occurrence of infections caused by multidrug‐resistant (MDR) bacteria drives the need for new antibacterial drugs. Due to current lack antibiotic discovery and development, strategies fight MDR are urgently needed. Efforts develop adjuvants increase effectiveness existing antibiotics design delivery systems essential address this issue. Here, a bioinspired system equipped with combination therapy paracellular transport is shown enhance efficacy against bacterial improving oral delivery. A screening platform established using an in vitro‐induced high polymyxin‐resistant strain acquire plumbagin, which enhances polymyxin. Functionalized milk extracellular vesicles (FMEVs) coloaded polymyxin plumbagin cleared 99% within 4 h. Mechanistic studies revealed that drug damaged membrane, disrupted energy metabolism, accelerated death. Finally, FMEVs efficiently transported transcellularly through citric acid‐mediated reversible opening tight junctions showed Escherichia coli ‐associated peritonitis–sepsis model mice. These findings provide potential therapeutic strategy improve enhancing biomimetic platform.

Language: Английский

Citations

0