Characterization and Role of Glucagon-Like Peptide 1 Receptor in the Lacrimal Gland: Novel Insights into Diabetic Dry Eye Pathogenesis DOI
Yan Sun, Yue Zhang, Fan Shi

et al.

American Journal Of Pathology, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 1, 2024

Language: Английский

Tirzepatide prevents neurodegeneration through multiple molecular pathways DOI Creative Commons

Rosaria Anna Fontanella,

Puja Ghosh,

Ada Pesapane

et al.

Journal of Translational Medicine, Journal Year: 2024, Volume and Issue: 22(1)

Published: Jan. 29, 2024

Abstract Background Several evidence demonstrated that glucagon-like peptide 1 receptor agonists (GLP1-RAs) reduce the risk of dementia in type 2 diabetes patients by improving memory, learning, and overcoming cognitive impairment. In this study, we elucidated molecular processes underlying protective effect Tirzepatide (TIR), a dual glucose-dependent insulinotropic polypeptide agonist (GIP-RA)/ GLP-1RA, against learning memory disorders. Methods We investigated effects TIR on markers neuronal growth (CREB BDNF), apoptosis (BAX/Bcl2 ratio) differentiation (pAkt, MAP2, GAP43, AGBL4), insulin resistance (GLUT1, GLUT4, GLUT3 SORBS1) neuroblastoma cell line (SHSY5Y) exposed to normal high glucose concentration. The potential role DNA methylation genes involved neuroprotection epigenetic modulators (miRNA 34a), 212), 29c) was also investigated. proliferation detected measuring Ki-67 through flow cytometry. data were analysed SPSS IBM Version 23 or GraphPad Prism 7.0 software expressed as means ± SEM. Differences between mean values considered significant at p-value < 0.05. used for drawing figures. Results For first time, it highlighted: (a) activation pAkt/CREB/BDNF pathway downstream signaling cascade; (b) efficacy neuroprotection; (c) counteracting hyperglycemia resistance-related level. Conclusions can ameliorate glucose-induced neurodegeneration overcome resistance. Thus, study provides new insight into diabetes-related neuropathy. Graphical

Language: Английский

Citations

17
The role of oxidative stress in the pathogenesis of ocular diseases: an overview DOI
Miao Zhang, Ruixue Zhang, Xiaoyue Zhao

et al.

Molecular Biology Reports, Journal Year: 2024, Volume and Issue: 51(1)

Published: March 27, 2024

Language: Английский

Citations

10
Advances in Nano-Functional Materials in Targeted Thrombolytic Drug Delivery DOI Creative Commons

Tengfei Ren,

Yuexi Mi,

Jingjing Wei

et al.

Molecules, Journal Year: 2024, Volume and Issue: 29(10), P. 2325 - 2325

Published: May 15, 2024

Thrombotic disease has been listed as the third most fatal vascular in world. After decades of development, clinical thrombolytic drugs still cannot avoid occurrence adverse reactions such bleeding. A number studies have shown that application various nano-functional materials thrombus-targeted drug delivery, combined with external stimuli, magnetic, near-infrared light, ultrasound, etc., enrich thrombus site and use properties for collaborative thrombolysis, which can effectively reduce bleeding improve thrombolysis efficiency. In this paper, research progress organic nanomaterials, inorganic biomimetic nanomaterials delivery is briefly reviewed.

Language: Английский

Citations

4
Oxidative stress in diabetes mellitus and its complications: From pathophysiology to therapeutic strategies DOI Creative Commons
Xingyu Chen, Na Xie,

Lixiang Feng

et al.

Chinese Medical Journal, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 8, 2024

Oxidative stress due to aberrant metabolism is considered as a crucial contributor diabetes and its complications. Hyperglycemia hyperlipemia boost excessive reactive oxygen species generation by elevated mitochondrial respiration, increased nicotinamide adenine dinucleotide phosphate oxidase activity, enhanced pro-oxidative processes, including protein kinase C pathways, hexosamine, polyol, advanced glycation endproducts, which exacerbate oxidative stress. plays significant role in the onset of associated complications impairing insulin production, increasing resistance, maintaining hyperglycemic memory, inducing systemic inflammation. A more profound comprehension molecular processes that link new preventive therapeutic strategies. Therefore, this review discusses mechanisms underlying how contributes mellitus We also summarize current approaches for prevention treatment targeting pathways diabetes.

Language: Английский

Citations

4
Semaglutide and the risk of adverse liver outcomes in patients with nonalcoholic fatty liver disease and type 2 diabetes: a multi-institutional cohort study DOI

Chia-Chih Kuo,

Min‐Hsiang Chuang, Chun‐Hsien Li

et al.

Hepatology International, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 27, 2024

Language: Английский

Citations

4
A multi enzyme study reviewing the role of target enzymes in Alzheimer’s disease and unveiling potential inhibitors with insights on their present and future assessment DOI
Sanaa Zaki, Samiullah Khan, Ruhi Ali

et al.

Medicinal Chemistry Research, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 31, 2025

Language: Английский

Citations

0
Semaglutide ameliorates metabolic disorders in offspring via regulation of oocyte ROS of pre-pregnancy obesity mice DOI

Junkai Zhang,

Xiaoping Li,

Yang Tang

et al.

Acta Pharmacologica Sinica, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 21, 2025

Language: Английский

Citations

0
Semaglutide Ameliorates Neuroinflammation Caused by Enterogenous Pyrogen in APP/PS1 Mice DOI Creative Commons
Yuan Yuan,

Jiawei Zhang,

Ziyao Zhang

et al.

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: March 3, 2025

Abstract Background and purpose: Alzheimer's disease (AD) is a neurodegenerative characterized by progressive cognitive dysfunction, which common in the elderly. In recent years, it has been reported that glucagon-like peptide 1 (GLP-1) analogues have neuroprotective function. However, mechanism of GLP-1 improving neurological function not fully clarified. This study attempts to clarify alleviating AD phenotype. Methods: this study, modified once-weekly analogue, Semaglutide, was used treat 8-month-old amyloid precursor protein / presenilin (APP/PS1) transgenic mice. By means ethology, molecular biology 16s rRNA amplicon sequencing, confirmed Semaglutide alleviated phenotype APP/PS1 Results: improved behavioral performance mice, reduced neuronal damage aggregation amyloid-β (Aβ) plaques, enhanced synaptic plasticity. also attenuated pyroptosis mediated NOD-like receptor thermal domain associated 3 (NLRP3), inflammatory reaction toll-like 4 (TLR4) mitochondrial microglia as well structure blood-brain barrier (BBB) Conclusion: may repair alleviate central nervous system injury caused displacement pyrogen gut

Language: Английский

Citations

0
IL-11 ameliorates oxidative stress damage in neurons after spinal cord injury by activating the JAK/STAT signaling pathway DOI Creative Commons
Yang Sun, Song Xue, Zhijun Geng

et al.

International Immunopharmacology, Journal Year: 2023, Volume and Issue: 127, P. 111367 - 111367

Published: Dec. 30, 2023

Excess reactive oxygen species (ROS) generated by oxidative stress is a crucial factor affecting neuronal dysfunction after spinal cord injury (SCI). IL-11 has been reported to have antioxidative capacity. In the present study, we investigated protective effect and mechanism of against cell damage caused imbalance.

Language: Английский

Citations

10
Role of reactive oxygen species in regulating epigenetic modifications DOI
Yutong Chen, Yingqiang Shen

Cellular Signalling, Journal Year: 2024, Volume and Issue: 125, P. 111502 - 111502

Published: Nov. 7, 2024

Language: Английский

Citations

3