Leveraging nature’s nanocarriers: Translating insights from extracellular vesicles to biomimetic synthetic vesicles for biomedical applications

Science Advances, Journal Year: 2025, Volume and Issue: 11(9)

Published: Feb. 26, 2025

Naturally occurring extracellular vesicles (EVs) and synthetic nanoparticles like liposomes have revolutionized precision diagnostics medicine. EVs excel in biocompatibility cell targeting, while offer enhanced drug loading capacity scalability. The clinical translation of is hindered by challenges including low yield heterogeneity, whereas face rapid immune clearance limited targeting efficiency. To bridge these gaps, biomimetic (SVs) emerged as innovative platforms, combining the advantageous properties liposomes. This review emphasizes critical aspects EV biology, such mechanisms EV-cell interaction source-dependent functionalities modulation, tissue regeneration, informing SV engineering. We reviewed a broad array SVs, with focus on lipid bilayered functionalized proteins. These include cell-derived nanovesicles, protein-functionalized liposomes, hybrid vesicles. By addressing current highlighting opportunities, this aims to advance SVs for transformative biomedical applications.

Language: Английский

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Biomimetic Nanoparticle Based Targeted mRNA Vaccine Delivery as a Novel Therapy for Glioblastoma Multiforme

AAPS PharmSciTech, Journal Year: 2025, Volume and Issue: 26(3)

Published: Feb. 21, 2025

Language: Английский

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Exosome-Based Drug Delivery Systems

IntechOpen eBooks, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 11, 2025

Extracellular vesicles, especially exosomes, have attracted widespread attention in the biomedical field recent years. They a unique ability to efficiently transport variety of bioactive molecules, property that makes them show great potential precision medicine. In addition, exosomes can evade detection by immune system, providing new solution for drug delivery and cancer research. This manuscript provides an overview exosome biogenesis, isolation-related techniques, their application as therapeutic vehicles. We discuss various strategies loading exosomal cargo engineering targeted delivery, highlighting advances exosome-based vaccines personalized therapies. book chapter concludes emphasizing transformative impact therapeutics on medicine, outlining future direction this its overcome traditional limitations.

Language: Английский

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Exosomes in cartilage microenvironment regulation and cartilage repair

Frontiers in Cell and Developmental Biology, Journal Year: 2025, Volume and Issue: 13

Published: March 5, 2025

Osteoarthritis (OA) is a debilitating disease that predominantly impacts the hip, hand, and knee joints. Its pathology defined by progressive degradation of articular cartilage, formation bone spurs, synovial inflammation, resulting in pain, joint function limitations, substantial societal familial burdens. Current treatment strategies primarily target pain alleviation, yet improved interventions addressing underlying are scarce. Recently, exosomes have emerged as subject growing interest OA therapy. Numerous studies investigated to offer promising therapeutic approaches for through diverse vivo vitro models, elucidating mechanisms which from various cell sources modulate cartilage microenvironment promote repair. Preclinical investigations demonstrated regulatory effects originating human cells, including mesenchymal stem cells (MSC), fibroblasts, chondrocytes, macrophages, derived Chinese herbal medicines, on modulation repair signaling pathways. Additionally, encompass matrix, proliferation migration autophagy, apoptosis, mitigation oxidative stress. An increasing number exosome carrier scaffolds under development. Our review adopts multidimensional approach enhance comprehension pivotal functions exerted sourced types OA. Ultimately, our aim pinpoint targets capable regulating facilitating

Language: Английский

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Biologics-based technologies for highly efficient and targeted RNA delivery

Molecular Therapy, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 1, 2024

Language: Английский

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In vivo gene editing and in situ generation of chimeric antigen receptor cells for next-generation cancer immunotherapy

Journal of Hematology & Oncology, Journal Year: 2024, Volume and Issue: 17(1)

Published: Nov. 13, 2024

Chimeric antigen receptor (CAR) cell therapy has achieved groundbreaking success in treating hematological malignancies. However, its application to solid tumors remains challenging due complex manufacturing processes, limited vivo persistence, and transient therapeutic effects. In CAR-immune cells induced by gene delivery systems loaded with CAR genes gene-editing tools have shown efficiency for anti-tumor immunotherapy. situ programming of autologous immune avoids the safety concerns allogeneic cells, manufacture could be standardized. Therefore, editing generation might potentially overcome abovementioned limitations current therapy. This review mainly focuses on structures, tools, techniques applied immunotherapy help design develop The recent applications both hematologic malignancies are investigated. To sum up, holds promise offering a practical, cost-effective, efficient, safe, widely applicable approach next-generation

Language: Английский

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Extracellular vesicle-based drug delivery systems in cancer

Extracellular Vesicle, Journal Year: 2024, Volume and Issue: 4, P. 100053 - 100053

Published: Oct. 4, 2024

Language: Английский

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