The Application of Quantum Dots in Dental and Oral Medicine: A Scoping Review DOI
Yuchen Liu, Nannan Wang, Danchen Qin

et al.

Journal of Dentistry, Journal Year: 2024, Volume and Issue: unknown, P. 105536 - 105536

Published: Dec. 1, 2024

Language: Английский

Biomolecule-based engineered nanoparticles for Cancer Theranostics DOI

Narayanan Parthasarathy,

Ramar Thangam, Babu Rithisa

et al.

Coordination Chemistry Reviews, Journal Year: 2025, Volume and Issue: 530, P. 216489 - 216489

Published: Feb. 3, 2025

Language: Английский

Citations

1
Hidden in Plain Sight: Clinical Imaging of the Tumor Microenvironment with PET DOI
Timothy H. Witney

Cancer Discovery, Journal Year: 2025, Volume and Issue: 15(2), P. 264 - 266

Published: Feb. 7, 2025

Summary: PET imaging enables the spatiotemporal assessment of tumor biomarkers. In this issue, Kong and colleagues describe clinical tumor-associated fibroblasts, which improved diagnostic accuracy management a subset patients with medullary thyroid carcinoma. See related article by et al., p. 316

Language: Английский

Citations

1
Porphyrin-based metal-organic frameworks for cancer theranostics DOI Creative Commons

Liandi Guan,

Fang Liu,

Cun Zhang

et al.

Advanced Sensor and Energy Materials, Journal Year: 2024, Volume and Issue: 3(4), P. 100123 - 100123

Published: Aug. 28, 2024

Language: Английский

Citations

4
Enhanced Cytotoxicity of [10]-Gingerol-Coumarin-Triazole Hybrid as a Theranostic Agent for Triple Negative Breast Cancer DOI Creative Commons

Arthur Deponte Zutião,

Bianca Cruz Pachane,

Paulo Sérgio Gonçalves Nunes

et al.

ACS Medicinal Chemistry Letters, Journal Year: 2025, Volume and Issue: 16(3), P. 436 - 443

Published: Feb. 10, 2025

A leading cause of death worldwide, breast cancer is the second most prevalent in women. Triple-negative an aggressive subtype that lacks targeted therapies and requires novel therapeutic approaches clinical practice to improve overall survival. Theranostic agents integrate diagnostic capabilities a single entity are promising strategies for personalized management. Hybrid compounds combining biologically relevant moieties with different modes action can enhance cytotoxicity pharmacological properties. We focus on hybrid containing coumarin, triazole, [10]-gingerol, compound known antimetastatic potential TNBC. The LSPN281 exhibited superior cytotoxic activity TNBC cell line vitro compared individual coumarin [10]-gingerol controls. Additionally, shows enhanced cellular uptake mitochondrial localization, suggesting its as theranostic agent

Language: Английский

Citations

0
Structure–Activity Relationship of Hemicyanine Molecules: Mitochondrion-Targeting Hemicyanine Fluorescent Molecular Probes for HSO3– Recognition and Near-Infrared Image-Guided Photothermal/Photodynamic Synergetic Therapy DOI
Lu Zhang, Ke Yan,

Shuang Min

et al.

The Journal of Physical Chemistry Letters, Journal Year: 2025, Volume and Issue: unknown, P. 1746 - 1752

Published: Feb. 10, 2025

Hemicyanine molecules have unparalleled potential in the fields of fluorescence sensing, bioimaging, and disease therapeutics due to their excellent optical properties, cell penetration, mitochondrial targeting, photosensitivity. Herein, three dual-cation hemicyanine molecular probes named DCy, PDCy, TDCy were developed. All them could detect HSO3-, PDCy recognize HSO3- under 365 nm ultraviolet light or sunlight. In addition, is a multifunctional molecule, which has following advantages: simple synthesis, red near-infrared dual-channel imaging, photothermal/photodynamic synergistic therapy capabilities. Upon analysis correlation between structures recognition, photosensitivity, photothermal activity, cytotoxicity, structure-activity relationship be summarized, provide guidance for subsequent research development.

Language: Английский

Citations

0
Role of emerging theranostic technologies in precision oncology: revolutionizing cancer diagnosis and treatment DOI Creative Commons
Biruk Demisse Ayalew,

Abdullah,

Saim Mahmood Khan

et al.

ONCOLOGIE, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 24, 2025

Language: Английский

Citations

0
Dansylated Amino Acid–Modified Long-Acting PSMA Derivatives68Ga/177Lu-LNC1011 as Prostate Cancer Theranostics DOI

Hongzhang Yang,

Jiarou Wang,

Xuejun Wen

et al.

Journal of Nuclear Medicine, Journal Year: 2025, Volume and Issue: unknown, P. jnumed.124.268959 - jnumed.124.268959

Published: March 20, 2025

Prostate-specific membrane antigen (PSMA)-targeted radiopharmaceutical therapy has demonstrated promising potential for treating metastatic castration-resistant prostate cancer. Recently, albumin-binding motif-modified PSMA radioligands with prolonged blood circulation were developed to improve tumor uptake and therapeutic effectiveness, properties which, however, associated an increased risk of bone marrow toxicity. This study presents new PSMA-targeted incorporating dansylated amino acids as relatively weak preferable albumin binders achieve a fine balance between accumulation, safety, diagnostic efficacy, facilitating unified approach theranostics within single molecular framework. Methods: Three novel ligands ([68Ga]Ga-Dan-Gly-PSMA, [68Ga]Ga-Dan-Nva-PSMA, [68Ga]Ga-Dan-Phe-PSMA, denoted [68Ga]Ga-LNC1011) synthesized measured the human serum through ultrafiltration experiments. Binding affinity PSMA-targeting specificity investigated using saturation binding assay cell in PSMA-induced cancer 3 line (PC3-PIP). PET imaging PC3-PIP tumor-bearing mice was performed evaluate preclinical pharmacokinetics efficiency 68Ga-labeled ligands. Tumor [177Lu]Lu-LNC1011 evaluated SPECT/CT biodistribution studies. Radiopharmaceutical studies conducted systematically assess effect radioligand. Results: various successfully radiochemical yield greater than 97%. In xenograft model, tumor/heart, tumor/liver, tumor/kidney, tumor/muscle ratios 9.82 ± 2.35, 12.42 3.71, 4.36 0.29, 52.88 12.08 at 4 h after injection, respectively. Biodistribution confirmed significantly higher (127.36 16.95 %ID/g) over [177Lu]Lu-PSMA-617 (17.44 6.29 no decrease up 72 which corroborated SPECT imaging. A injection 9.3 MBq achieved 89.43% inhibition growth, equivalent 18.5 (90.87%). [68Ga]Ga-LNC1011 PET/CT scans patients identified many lesions [68Ga]Ga-PSMA-11 did, confirming its efficacy. Conclusion: 68Ga/177Lu-LNC1011, characterized by high retention along timely clearance from normal organs tissues, thus emerges single-molecule theranostic

Language: Английский

Citations

0
Lanthanide-Based Core-Shell Nanoconstructs for Cancer Theragnostics DOI

Dipak Bari,

Vivek Rajkule,

S.D. Tiwari

et al.

Published: Jan. 1, 2025

Language: Английский

Citations

0
Nano-chameleons: A review on cluster of differentiation-driven immune cell-engineered nanoarchitectonics for non-small cell lung cancer DOI

Niharika Puri,

Prajakta Sahane,

Vivek Phatale

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 310, P. 143440 - 143440

Published: April 23, 2025

Language: Английский

Citations

0
In situ modified mesoporous silica nanoparticles: synthesis, properties and theranostic applications DOI Creative Commons
Chloe Trayford, Sabine van Rijt

Biomaterials Science, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

This review describes in situ modification of MSNs and how this effects their material properties. It highlights application theranostics, oncology, regenerative medicine field, concluding with future challenges for clinical use.

Language: Английский

Citations

2