Multifunctional Micro/Nano-Textured Titanium with Bactericidal, Osteogenic, Angiogenic and Anti-inflammatory Properties: Insights from In Vitro and In Vivo Studies DOI Creative Commons
Théo Ziegelmeyer, Karolinne Martins de Sousa, Tzu‐Ying Liao

et al.

Materials Today Bio, Journal Year: 2025, Volume and Issue: 32, P. 101710 - 101710

Published: March 29, 2025

Titanium (Ti) is widely used as an implantable material for bone repair in orthopedics and dentistry. However, Ti implants are vulnerable to bacterial infections, which can compromise patient recovery lead implant failure. While a controlled inflammatory response promotes regeneration, chronic inflammation caused by infections Bone complex process inflammation, angiogenesis osteogenesis tightly interconnected, requiring cooperation between mesenchymal stem cells (MSC), macrophages endothelial cells. Here, we fabricated bio-inspired with either microstructured (Micro Ti) or nanostructured (Nano surface textures that exhibit robust mechano-bactericidal properties. In vitro, both textured surfaces improved blood coagulation osteogenic marker expression compared smooth surfaces. Additionally, Nano promoted macrophage polarization towards the M2 phenotype enhanced paracrine effects of MSCs on angiogenesis, key processes tissue regeneration. vivo kinetic analysis reconstruction rat calvarial model showed osseointegration, evidenced increased volume, mineral density, bone-implant contact. Notably, Micro no significant differences from control implants. These findings highlight potential nanopatterns simultaneously prevent enhance osseointegration modulating protein adsorption, osteogenesis. This study provides new insights into development bifunctional implants, offering perspectives next generation bone-related biomaterials.

Language: Английский

Application of Light-Responsive Nanomaterials in Bone Tissue Engineering DOI Creative Commons
Aiguo Liu, Chenxu Wang, Shuang Deng

et al.

Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(1), P. 98 - 98

Published: Jan. 13, 2025

The application of light-responsive nanomaterials (LRNs) in bone tissue engineering shows broad prospects, especially promoting healing and regeneration. With a deeper understanding the mechanisms defects disorders, LRNs are receiving increasing attention due to their non-invasive, controllable, efficient properties. These materials can regulate cellular biological reactions promote cell adhesion, proliferation, differentiation by absorbing specific wavelengths light converting them into physical chemical signals. In addition, unique surface morphology biocompatibility enable effectively load drugs engineering, achieve precise release, optimize regeneration process. Through photothermal photodynamic therapy, these also possess antibacterial properties play an important role repair infectious defects. Although have shown significant advantages regeneration, series challenges still need be overcome widespread effective clinical applications. This article summarizes basic principles, classification, potential applications aiming provide reference for future research

Language: Английский

Citations

1
Dual-responsive and Rnewable Antimicrobial Surfaces via Catechol-Based Adhesion for Dental Unit Water Lines DOI
Wei Liu,

Shihua Mao,

Yuedan Xu

et al.

Surfaces and Interfaces, Journal Year: 2025, Volume and Issue: unknown, P. 106130 - 106130

Published: Feb. 1, 2025

Language: Английский

Citations

0
Periprosthetic osteolysis: Mechanisms and potential treatment strategies DOI
Fang Yao,

Yongneng Bao,

Qian Meng

et al.

Cellular Signalling, Journal Year: 2025, Volume and Issue: unknown, P. 111758 - 111758

Published: March 1, 2025

Language: Английский

Citations

0
Multifunctional Micro/Nano-Textured Titanium with Bactericidal, Osteogenic, Angiogenic and Anti-inflammatory Properties: Insights from In Vitro and In Vivo Studies DOI Creative Commons
Théo Ziegelmeyer, Karolinne Martins de Sousa, Tzu‐Ying Liao

et al.

Materials Today Bio, Journal Year: 2025, Volume and Issue: 32, P. 101710 - 101710

Published: March 29, 2025

Titanium (Ti) is widely used as an implantable material for bone repair in orthopedics and dentistry. However, Ti implants are vulnerable to bacterial infections, which can compromise patient recovery lead implant failure. While a controlled inflammatory response promotes regeneration, chronic inflammation caused by infections Bone complex process inflammation, angiogenesis osteogenesis tightly interconnected, requiring cooperation between mesenchymal stem cells (MSC), macrophages endothelial cells. Here, we fabricated bio-inspired with either microstructured (Micro Ti) or nanostructured (Nano surface textures that exhibit robust mechano-bactericidal properties. In vitro, both textured surfaces improved blood coagulation osteogenic marker expression compared smooth surfaces. Additionally, Nano promoted macrophage polarization towards the M2 phenotype enhanced paracrine effects of MSCs on angiogenesis, key processes tissue regeneration. vivo kinetic analysis reconstruction rat calvarial model showed osseointegration, evidenced increased volume, mineral density, bone-implant contact. Notably, Micro no significant differences from control implants. These findings highlight potential nanopatterns simultaneously prevent enhance osseointegration modulating protein adsorption, osteogenesis. This study provides new insights into development bifunctional implants, offering perspectives next generation bone-related biomaterials.

Language: Английский

Citations

0