Hydrogen‐Bonded Organic Framework‐Based NIR‐II Activated Hydrogen Production for Treatment of Alzheimer's Disease Model Mice DOI

Dongqin Yu,

Haochen Zhang,

Xiubo Du

et al.

Small, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 24, 2025

Abstract Oxidative stress is the crucial pathologic factor for causing neuron death and cognitive impairment in progression of Alzheimer's disease (AD). As a special antioxidant, molecular hydrogen (H 2 ) responsible alleviating oxidative associated inflammatory symptoms. However, vivo continuous efficient accumulation rather difficult to realize, thus frequent dosing required ensure desired therapeutic effect. Herein, hydrogen‐bonded organic frameworks (HOFs) composites are rationally designed achieve sustainable near‐infrared II (NIR‐II) photocatalytic evolution reaction relieving neuroinflammation AD model mice. The HOFs mainly consist three parts: building block porphyrin as photocatalyst, DSM (NIR‐II‐absorbing pyridinium hemicyanine dye) fluorescent emitter, platinum nanoparticles co‐catalyst. Under NIR‐II laser illumination, acts an energy transducer activate produce reductive situ. Specially, selectively binds with accumulated Cu ions Aβ plaques boosts H evolution. KLVFFAED (KD8) covalently grafted on improve blood–brain barrier permeability vivo. This system exhibits admirable effect inflammation recovering disorder mice, providing new way exploring used therapy.

Language: Английский

An albumin-prodrug injectable formulation for synergistic cancer immunotherapy DOI
Yang Li, Yuting Lu, Xiaoling Zhu

et al.

Journal of Colloid and Interface Science, Journal Year: 2025, Volume and Issue: 686, P. 1019 - 1032

Published: Feb. 3, 2025

Language: Английский

Citations

0
Hydrogen‐Bonded Organic Framework‐Based NIR‐II Activated Hydrogen Production for Treatment of Alzheimer's Disease Model Mice DOI

Dongqin Yu,

Haochen Zhang,

Xiubo Du

et al.

Small, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 24, 2025

Abstract Oxidative stress is the crucial pathologic factor for causing neuron death and cognitive impairment in progression of Alzheimer's disease (AD). As a special antioxidant, molecular hydrogen (H 2 ) responsible alleviating oxidative associated inflammatory symptoms. However, vivo continuous efficient accumulation rather difficult to realize, thus frequent dosing required ensure desired therapeutic effect. Herein, hydrogen‐bonded organic frameworks (HOFs) composites are rationally designed achieve sustainable near‐infrared II (NIR‐II) photocatalytic evolution reaction relieving neuroinflammation AD model mice. The HOFs mainly consist three parts: building block porphyrin as photocatalyst, DSM (NIR‐II‐absorbing pyridinium hemicyanine dye) fluorescent emitter, platinum nanoparticles co‐catalyst. Under NIR‐II laser illumination, acts an energy transducer activate produce reductive situ. Specially, selectively binds with accumulated Cu ions Aβ plaques boosts H evolution. KLVFFAED (KD8) covalently grafted on improve blood–brain barrier permeability vivo. This system exhibits admirable effect inflammation recovering disorder mice, providing new way exploring used therapy.

Language: Английский

Citations

0