Prevalence, spectrum, and the relations between short-term and long-term post-acute sequelae of COVID-19 in children DOI Creative Commons
Е. Р. Мескина, M. K. Khadisova, A. Yu. Ushakova

et al.

Journal of microbiology epidemiology immunobiology, Journal Year: 2025, Volume and Issue: 102(1), P. 43 - 61

Published: March 30, 2025

Background. Data on the prevalence of post-COVID-19 condition (PCC) in children differ due to lack specific diagnostic criteria, reliable biomarkers, and limitations many studies. It is important study association between PCC, previous functional disorders, any events post-acute period COVID-19 estimate true burden PCC children. The aim. To determine relation initial disorders during year after a mild form acute respiratory tract infections (ARTI) other etiologies. Materials methods. prospective using continuous sampling method included under 18 years age hospitalized with suspected COVID-19, whom was confirmed by RT-PCR (n = 121) or excluded molecular serological methods (ARTI group, n 105). Information patients collected from September 2020 December 2021 questionnaires at index points: hospital discharge 1, 3, 6 12 months. Severe chronic diseases were excluded. Functional anamnesis associated health observation, severity symptoms taken into account. analysis performed groups ≥ age. Symptoms grouped clusters. Results. Any identified frequency 32–39% (in ≥6 years, respectively). most common psycho-emotional, autonomic dysfunction (AD) cluster. cases duration 3–6 After adjustment for age, AD history recurrent ARTI episodes, no difference found symptom clusters except hyposmia, incidence which decreased 14.3% first point 2.4% one year. Among without an year, de novo rare phenomenon (2.7–8.0%) differences controls. risks significantly increased (adjusted OR 1 month 3.19 (95% CI 1.89–5.38), months 3.33 1.81–6.15)). Multiple (5–25) persistent (at all points) rated as significant occurred rarely (1.7% 0.4–4.9)), but more often — 25%) 95% 13.6–39.6%) (difference 23.3% (10.9–35.7%), 14.8 (4.4–50.6), p 0.001). Recurrent episodes risk factor increase cognitive cluster complaints vagotonic observation. Conclusion. results obtained indirectly support concept that somatoform disorder, probably sociogenic nature, who are anxious baseline. Some consequences really need medical psychosocial rehabilitation. provides new insights widespread viral infections.

Language: Английский

Prevalence, spectrum, and the relations between short-term and long-term post-acute sequelae of COVID-19 in children DOI Creative Commons
Е. Р. Мескина, M. K. Khadisova, A. Yu. Ushakova

et al.

Journal of microbiology epidemiology immunobiology, Journal Year: 2025, Volume and Issue: 102(1), P. 43 - 61

Published: March 30, 2025

Background. Data on the prevalence of post-COVID-19 condition (PCC) in children differ due to lack specific diagnostic criteria, reliable biomarkers, and limitations many studies. It is important study association between PCC, previous functional disorders, any events post-acute period COVID-19 estimate true burden PCC children. The aim. To determine relation initial disorders during year after a mild form acute respiratory tract infections (ARTI) other etiologies. Materials methods. prospective using continuous sampling method included under 18 years age hospitalized with suspected COVID-19, whom was confirmed by RT-PCR (n = 121) or excluded molecular serological methods (ARTI group, n 105). Information patients collected from September 2020 December 2021 questionnaires at index points: hospital discharge 1, 3, 6 12 months. Severe chronic diseases were excluded. Functional anamnesis associated health observation, severity symptoms taken into account. analysis performed groups ≥ age. Symptoms grouped clusters. Results. Any identified frequency 32–39% (in ≥6 years, respectively). most common psycho-emotional, autonomic dysfunction (AD) cluster. cases duration 3–6 After adjustment for age, AD history recurrent ARTI episodes, no difference found symptom clusters except hyposmia, incidence which decreased 14.3% first point 2.4% one year. Among without an year, de novo rare phenomenon (2.7–8.0%) differences controls. risks significantly increased (adjusted OR 1 month 3.19 (95% CI 1.89–5.38), months 3.33 1.81–6.15)). Multiple (5–25) persistent (at all points) rated as significant occurred rarely (1.7% 0.4–4.9)), but more often — 25%) 95% 13.6–39.6%) (difference 23.3% (10.9–35.7%), 14.8 (4.4–50.6), p 0.001). Recurrent episodes risk factor increase cognitive cluster complaints vagotonic observation. Conclusion. results obtained indirectly support concept that somatoform disorder, probably sociogenic nature, who are anxious baseline. Some consequences really need medical psychosocial rehabilitation. provides new insights widespread viral infections.

Language: Английский

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