Physical health in young males and risk of chronic musculoskeletal, cardiovascular, and respiratory diseases by middle age: A population-based cohort study
PLoS Medicine,
Journal Year:
2025,
Volume and Issue:
22(1), P. e1004517 - e1004517
Published: Jan. 21, 2025
Background
Cardiovascular,
respiratory,
and
musculoskeletal
disease
are
among
the
leading
causes
of
disability
in
middle-aged
older
people.
Health
lifestyle
factors
youth
have
known
associations
with
cardiovascular
or
respiratory
adulthood,
but
largely
unknown
disease.
Methods
findings
We
included
approximately
40,000
18-year-old
Swedish
males,
who
completed
their
conscription
examination
1969
to
1970,
followed
up
until
age
60
years.
Exposures
interest
were
physical
health:
body
mass
height,
blood
pressure,
pulse
at
rest,
muscle
strength,
cardiorespiratory
fitness,
hematocrit;
self-reported
lifestyle:
smoking,
alcohol,
drug
use;
overall,
headache
gastrointestinal.
participants
through
National
Patient
Register
for
incidence
common
(osteoarthritis,
back
pain,
shoulder
lesions,
joint
myalgia),
(ischemic
heart
disease,
atrial
fibrillation),
diseases
(asthma,
chronic
obstructive
pulmonary
bronchitis).
analyzed
using
general
estimating
equations
Poisson
regression
all
exposures
one
model
adjusted
parental
education
occupation.
found
that
higher
was
associated
risk
(risk
ratio
[RR]
per
1
standard
deviation
[SD]
1.12
[95%
confidence
interval,
CI
1.09,
1.16]),
(RR
1.22
1.17,
1.27]
SD)
1.14
1.05,
1.23]
SD).
Notably,
strength
fitness
(RRs
1.08
1.11]
1.06
1.01,
1.12]
SD
difference
exposure),
while
protective
against
both
0.91
0.85,
0.98]
0.85
0.73,
0.97]
exposure,
respectively).
confirmed
adverse
effects
ratios
when
comparing
11+
cigarettes
day
non-smoking
(95%
1.06,
1.22)
musculoskeletal,
1.58
1.44,
1.74)
cardiovascular,
1.93
1.60,
2.32)
diseases.
Self-reported
(category
“often”
compared
“never”)
1.38
1.21,
1.58])
1.29
1.07,
1.56]),
had
an
inconclusive
association
1.13
0.79,
1.60]).
No
large
consistent
other
exposures.
The
most
notable
specific
conditions
osteoarthritis
1.23
1.15,
1.32]
pain
1.18
1.12,
1.24]
1.27
1.19,
1.36]
main
limitations
include
lack
adjustment
genetic
environmental
from
childhood,
register
data
available
males
only.
Conclusions
While
high
a
factor
3
studied
groups
diseases,
increased
middle
age.
speculate
these
mediated
by
overload
acute
trauma.
Language: Английский
Ambulatory blood pressure variability in prediction of target organ injury: the SHIP AHOY study
Coral D. Hanevold,
No information about this author
Jang Dong Seo,
No information about this author
Stephen R. Daniels
No information about this author
et al.
Pediatric Nephrology,
Journal Year:
2025,
Volume and Issue:
unknown
Published: May 19, 2025
Language: Английский
Lean Mass Longitudinally Confounds Sedentary Time and Physical Activity With Blood Pressure Progression in 2513 Children
Journal of Cachexia Sarcopenia and Muscle,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 13, 2024
ABSTRACT
Background
Randomized
controlled
trials
have
reported
no
effect
of
moderate‐to‐vigorous
physical
activity
(MVPA)
on
reducing
blood
pressure
(BP)
in
youth,
probably
due
to
short
trial
durations.
This
study
examined
the
longitudinal
sedentary
time
(ST),
light
PA
(LPA)
and
MVPA
BP
11‐year‐old
children
followed
up
for
13
years
determine
confounding
mediating
role
body
composition.
Methods
Data
included
2513
from
Avon
Longitudinal
Study
Parents
Children
(ALSPAC),
UK
birth
cohort
who
had
data
at
least
one
time‐point
measure
accelerometer‐based
movement
behaviour
across
follow‐up
complete
measures
ages
11,
15
24
years.
Body
composition
was
assessed
with
dual‐energy
x‐ray
absorptiometry
all
points.
Multivariate
adjusted
generalized
linear
mixed‐effect
model
structural
equation
causal
mediation
analyses
were
conducted.
Results
Among
participants
(61%
female,
mean
[SD]
age
11.72
[0.21]
years),
ST
steadily
increased
~6
h/day
childhood
(age
11
years)
~9
young
adulthood
whereas
LPA
decreased,
but
an
inverted
U‐shaped
increase.
In
analysis,
after
full
adjustment,
a
1‐min
cumulative
positively
associated
systolic
(0.009
mmHg
[95%
CI
0.007–0.011];
p
<
0.001)
diastolic
BP.
A
inversely
(−0.007
[−0.009
−0.004];
0.001),
not
isotemporal
substitution
analyses,
replacement
10
min
equal
during
childhood,
adolescence
cumulatively
decreased
by
−2.63
−3.17
−2.08]
(
0.0001)
−1.93
−2.36
−1.50]
0.0001).
Replacing
statistically
significant
absolute
lean
mass.
The
association
fully
mediated
mass
(93%
mediation).
Increased
total
fat
partially
(19%–27%)
inverse
associations
Conclusions
Theoretically
replacing
min/day
spent
growth
through
may
lower
−3
−2
mmHg.
Lean
seems
more
than
relations
should
be
accounted
future
intervention
studies
paediatric
adult
population.
Language: Английский
Adolescent Blood Pressure and Early Age Stroke
Boris Fishman,
No information about this author
Adi Vinograd,
No information about this author
Avishai M. Tsur
No information about this author
et al.
NEJM Evidence,
Journal Year:
2024,
Volume and Issue:
3(12)
Published: Nov. 17, 2024
Underdiagnosis
of
relevant
risk
factors
has
contributed
to
the
increasing
stroke
incidence
in
young
adults.
Blood
pressure
cut-off
values
for
adolescents
are
neither
sex
specific
nor
based
on
cardiovascular
outcomes.
Language: Английский
Prognostic impact of hypertension grading
European Journal of Internal Medicine,
Journal Year:
2024,
Volume and Issue:
126, P. 83 - 88
Published: April 14, 2024
Language: Английский
High blood pressure and intracerebral haemorrhage. A recognized risk factor with new knowledge
European Journal of Preventive Cardiology,
Journal Year:
2024,
Volume and Issue:
unknown
Published: June 4, 2024
Language: Английский
Digitizing Paper-based Military health records from Norwegian males born in 1950 – assessments of data quality and applicability in research
Research Square (Research Square),
Journal Year:
2024,
Volume and Issue:
unknown
Published: April 10, 2024
Abstract
Aim
This
study
aims
to
present
and
assess
the
quality
of
military
health
data
extracted
from
paper-based
personnel
files
Norwegian
men
born
in
1950,
proposing
avenues
for
future
research.
Background
Archived
documents
contain
information
that
can
enrich
Armed
Forces
Health
Registry
(NAFHR)
with
more
detailed
clinical
measurements
older
birth
cohorts.
However,
uncertainty
exists
about
preservation
digital
reproduction
accuracy
research
purposes.
Methods
To
establish
an
infrastructure
at
National
Archives
Norway,
we
digitized
covering
approximately
60%
(n
=
17
324)
1950.
records
were
manually
transcribed,
transcribed
controlled
registered
NAFHR.
Clinical
measures
compared
results
comparable
national
surveys,
variations
between
conscription
board
examinations
on
first
day
service
explored.
Transcribed
cardiovascular
disease
(CVD)
risk
factor
tested
logistic
regression
models
their
predictive
ability.
Results
The
showed
good
compliance
readability,
overall
accurate
valid
measurements.
While
some
existed
two
examination
settings,
generally
aligned
survey
results.
Several
CVD
factors
cohort
expected
associations
mortality.
Conclusion
highlights
readability
data,
emphasizing
its
potential
public
through
Further
digitization
efforts
promise
enhanced
communication
expanded
opportunities.
Language: Английский