Internal medicine at the crossroads of long COVID diagnosis and management

Frontiers in Medicine, Journal Year: 2025, Volume and Issue: 12

Published: May 2, 2025

The lack of specificity in its definition is a major obstacle to both explanatory and therapeutic research long COVID. It brings together, on the one hand, patients with severe COVID-19 who suffer classic complications prolonged hospitalization decompensation comorbidities and, other non-severe acute report multiple symptoms that cannot be fully explained by biomechanical model. Indeed, despite numerous studies, it remains unclear how persistent viral infection, immunological or coagulation disturbances may contribute mechanistically Nevertheless, internal medicine should good place manage these patients. diversity evoke broad spectrum differential diagnoses are familiar internists. Their experience exploration unexplained also valuable. can reduce need for consultations specialists unnecessary laboratory imaging tests. However, COVID diagnosis limited exclusion all conditions one. An open non-dualistic approach required identify mechanisms explain symptoms. Based their clinical experience, most French internists responded an opinion survey consider corresponds closely functional somatic disorder (FSD) seek help mental health care assist management multi-disciplinary approach. as FSDs, usually reluctant managed specialists, given very physical nature presentation. Unfortunately, physicians turn take them, due poor knowledge about FSD, leading failure. Alternatively, comprehensive multidisciplinary orchestrated experienced internist generally well-accepted. includes providing rational cognitive explanations support behavioral changes tailored patient. While waiting hypothetical randomized controlled trials assessing drugs positive results, such holistic has been successfully applied many individuals generalization would require much broader training FSD providers.

Language: Английский

---

Pathophysiological, Neuropsychological, and Psychosocial Influences on Neurological and Neuropsychiatric Symptoms of Post-Acute COVID-19 Syndrome: Impacts on Recovery and Symptom Persistence

Biomedicines, Journal Year: 2024, Volume and Issue: 12(12), P. 2831 - 2831

Published: Dec. 13, 2024

Although the impact of post-acute COVID-19 syndrome (PACS) on patients and public health is undeniably significant, its etiology remains largely unclear. Much research has been conducted pathophysiology, shedding light various aspects; however, due to multitude symptoms clinical conditions that directly or indirectly define PACS, it challenging establish definitive causations. In this exploration, through systematically reviewing latest pathophysiological findings related neurological syndrome, we aim examine how psychosocial neuropsychological may overlap with ones, they not only serve as risk factors but also contribute persistence some primary disorder. Findings from our synthesis suggest psychological factors, such anxiety, depression, loneliness, interact in a self-reinforcing feedback loop. This cycle seems be affecting both physical distress, potentially increasing severity PACS symptoms. By pointing out interaction, review study, attempt offer new perspective interconnected nature psychological, psychosocial, emphasizing importance integrated treatment approaches disrupt improve outcomes when possible.

Language: Английский

---

Long COVID Diagnostics: An Unconquered Challenge

Annals of Internal Medicine, Journal Year: 2024, Volume and Issue: 177(9), P. 1279 - 1280

Published: Aug. 12, 2024

Language: Английский

---

Covid long : à la recherche de biomarqueurs

Revue Francophone des Laboratoires, Journal Year: 2024, Volume and Issue: 2024(567), P. 10 - 11

Published: Dec. 1, 2024

---

Diagnostic challenges of long COVID in children: a survey of pediatric health care providers’ preferences and practices

Frontiers in Pediatrics, Journal Year: 2024, Volume and Issue: 12

Published: Dec. 23, 2024

Given the challenges in diagnosing children with long COVID, we sought to explore diagnostic practices and preferences among clinicians. A ten-question survey assessed pediatric providers' clinical decision making for identifying evaluating COVID children. Of 120 respondents, 84 (70%) were physicians, 31 (26%) nurse practitioners, 5 (4%) physician assistants. The most common categories of symptoms identified as raising suspicion included cardiopulmonary symptoms, selected by 119 (99%) providers, neurocognitive 118 (98%) providers. However, there was more ambiguity on primary feature providers selecting a range key symptoms. all physical exam findings, postural orthostatic tachycardia, suggestive [identified 49 (41%) providers], whereas one-third reported no specific identifiable finding. Pediatric report variable evaluation patient demographics factors impacting whether diagnosis is considered. This variation reflects definition absence guidelines support identification disease treatment. study highlights an area need future advances COVID.

Language: Английский

---