Fundamentals of cancer metabolism

Science Advances, Journal Year: 2016, Volume and Issue: 2(5)

Published: May 6, 2016

Researchers provide a conceptual framework to understand current knowledge of the fundamentals cancer metabolism.

Language: Английский

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Understanding the Intersections between Metabolism and Cancer Biology

Cell, Journal Year: 2017, Volume and Issue: 168(4), P. 657 - 669

Published: Feb. 1, 2017

Language: Английский

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ROS signalling in the biology of cancer

Seminars in Cell and Developmental Biology, Journal Year: 2017, Volume and Issue: 80, P. 50 - 64

Published: June 4, 2017

Language: Английский

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Mitochondria-Targeted Triphenylphosphonium-Based Compounds: Syntheses, Mechanisms of Action, and Therapeutic and Diagnostic Applications

Chemical Reviews, Journal Year: 2017, Volume and Issue: 117(15), P. 10043 - 10120

Published: June 27, 2017

Mitochondria are recognized as one of the most important targets for new drug design in cancer, cardiovascular, and neurological diseases. Currently, effective way to deliver drugs specifically mitochondria is by covalent linking a lipophilic cation such an alkyltriphenylphosphonium moiety pharmacophore interest. Other delocalized cations, rhodamine, natural synthetic mitochondria-targeting peptides, nanoparticle vehicles, have also been used mitochondrial delivery small molecules. Depending on approach used, cell membrane potentials, more than 1000-fold higher concentration can be achieved. Mitochondrial targeting has developed study physiology dysfunction interaction between other subcellular organelles treatment variety diseases neurodegeneration cancer. In this Review, we discuss efforts target small-molecule compounds probing function, diagnostic tools potential therapeutics. We describe physicochemical basis accumulation chemistry strategies mitochondria, probes, sensors, examples bioactive compounds. Finally, review published attempts apply mitochondria-targeted agents cancer neurodegenerative

Language: Английский

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An Essential Role of the Mitochondrial Electron Transport Chain in Cell Proliferation Is to Enable Aspartate Synthesis

Cell, Journal Year: 2015, Volume and Issue: 162(3), P. 540 - 551

Published: July 1, 2015

Language: Английский

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Targeting mitochondria metabolism for cancer therapy

Nature Chemical Biology, Journal Year: 2014, Volume and Issue: 11(1), P. 9 - 15

Published: Dec. 17, 2014

Language: Английский

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Metformin: From Mechanisms of Action to Therapies

Cell Metabolism, Journal Year: 2014, Volume and Issue: 20(6), P. 953 - 966

Published: Oct. 30, 2014

Language: Английский

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Mitochondria and Cancer

Molecular Cell, Journal Year: 2016, Volume and Issue: 61(5), P. 667 - 676

Published: March 1, 2016

Language: Английский

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Supporting Aspartate Biosynthesis Is an Essential Function of Respiration in Proliferating Cells

Cell, Journal Year: 2015, Volume and Issue: 162(3), P. 552 - 563

Published: July 1, 2015

Language: Английский

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Adapting to obesity with adipose tissue inflammation

Nature Reviews Endocrinology, Journal Year: 2017, Volume and Issue: 13(11), P. 633 - 643

Published: Aug. 11, 2017

Language: Английский

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