Single‐cell RNA analysis of chromodomain‐encoding genes in mesenchymal stromal cells of the mouse dental pulp DOI
Timothy Becker,

Badam Enkhmandakh,

Dashzeveg Bayarsaihan

et al.

Journal of Cellular Biochemistry, Journal Year: 2024, Volume and Issue: 126(1)

Published: May 23, 2024

The chromodomain helicase DNA-binding (CHD) and chromobox (CBX) families of proteins play crucial roles in cell fate decisions, differentiation, proliferation a broad variety tissues types. CHD are ATP-dependent epigenetic enzymes actively engaged transcriptional regulation, DNA replication, damage repair, whereas CBX repressors mainly involved the formation heterochromatin. pleiotropic effects largely dependent on their versatility to interact with other key components machinery. Although function regulatory modes factors well established many types, little is known about during osteogenic differentiation. A single-cell RNA-sequencing analysis mouse incisor dental pulp revealed distinct spatiotemporal expression patterns CHD- CBX-encoding genes within different clusters mesenchymal stromal cells (MSCs) representing various stages Additionally, encoding interaction partners proteins, such as subunits trithorax-COMPASS polycomb chromatin remodeling complexes, exhibited differential co-expression behaviors MSC subpopulations. Thus, show partially overlapping but MSCs, suggesting decisions.

Language: Английский

Single‐cell RNA analysis of chromodomain‐encoding genes in mesenchymal stromal cells of the mouse dental pulp DOI
Timothy Becker,

Badam Enkhmandakh,

Dashzeveg Bayarsaihan

et al.

Journal of Cellular Biochemistry, Journal Year: 2024, Volume and Issue: 126(1)

Published: May 23, 2024

The chromodomain helicase DNA-binding (CHD) and chromobox (CBX) families of proteins play crucial roles in cell fate decisions, differentiation, proliferation a broad variety tissues types. CHD are ATP-dependent epigenetic enzymes actively engaged transcriptional regulation, DNA replication, damage repair, whereas CBX repressors mainly involved the formation heterochromatin. pleiotropic effects largely dependent on their versatility to interact with other key components machinery. Although function regulatory modes factors well established many types, little is known about during osteogenic differentiation. A single-cell RNA-sequencing analysis mouse incisor dental pulp revealed distinct spatiotemporal expression patterns CHD- CBX-encoding genes within different clusters mesenchymal stromal cells (MSCs) representing various stages Additionally, encoding interaction partners proteins, such as subunits trithorax-COMPASS polycomb chromatin remodeling complexes, exhibited differential co-expression behaviors MSC subpopulations. Thus, show partially overlapping but MSCs, suggesting decisions.

Language: Английский

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