Convergent evolution of epigenome recruited DNA repair across the Tree of Life DOI Creative Commons
J. Grey Monroe, Chaehee Lee, Daniela Quiroz

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 18, 2024

Abstract Mutations fuel evolution while also causing diseases like cancer. Epigenome-targeted DNA repair can help organisms protect important genomic regions from mutation. However, the adaptive value, mechanistic diversity, and of epigenome-targeted systems across tree life remain unresolved. Here, we investigated histone reader domains fused to protein MSH6 (MutS Homolog 6) over 4,000 eukaryotes. We uncovered a paradigmatic example convergent evolution: has independently acquired distinct domains; PWWP (metazoa) Tudor (plants), previously shown target modifications in active genes humans (H3K36me3) Arabidopsis (H3K4me1). Conservation shows signatures natural selection, particularly for amino acids that bind specific modifications. Species have gained or retained readers tend larger genome sizes, especially marked by significantly more introns genic regions. These patterns support previous theoretical predictions about co-evolution architectures mutation rate heterogeneity. The implications evolution, health, mutational origins genetic diversity life. Short Summary Fusions between mismatch evolved multiple times Eukaryotes show evidence providing insight into forces shaping

Language: Английский

Lifestyles shape genome size and gene content in fungal pathogens DOI Open Access
Anna Fijarczyk,

Pauline Hessenauer,

Richard C. Hamelin

et al.

Published: April 2, 2025

Fungi display a wide range of lifestyles and hosts. We still know little about the impact lifestyles, including pathogenicity, on their genome architecture. Here, we combined annotated 552 fungal genomes from class Sordariomycetes examined association between 12 genomic features two lifestyle traits: pathogenicity insect association. found that pathogens average tend to have larger number protein-coding genes, effectors, tRNA genes. In addition, non-repetitive size is than non-pathogenic species. However, this pattern not consistent across all groups. Insect endoparasites symbionts smaller sizes genes with longer exons; moreover, insect-vectored possess fewer compared those transmitted by insects. Our study shows are main contributors variation in seemingly similar can exhibit distinct architectures, depending host vector interactions.

Language: Английский

Citations

0
Lifestyles shape genome size and gene content in fungal pathogens DOI Open Access
Anna Fijarczyk,

Pauline Hessenauer,

Richard C. Hamelin

et al.

Published: April 2, 2025

Fungi display a wide range of lifestyles and hosts. We still know little about the impact lifestyles, including pathogenicity, on their genome architecture. Here, we combined annotated 552 fungal genomes from class Sordariomycetes examined association between 12 genomic features two lifestyle traits: pathogenicity insect association. found that pathogens average tend to have larger number protein-coding genes, effectors, tRNA genes. In addition, non-repetitive size is than non-pathogenic species. However, this pattern not consistent across all groups. Insect endoparasites symbionts smaller sizes genes with longer exons; moreover, insect-vectored possess fewer compared those transmitted by insects. Our study shows are main contributors variation in seemingly similar can exhibit distinct architectures, depending host vector interactions.

Language: Английский

Citations

0
Convergent evolution of epigenome recruited DNA repair across the Tree of Life DOI Open Access
J. Grey Monroe, Chaehee Lee, Daniela Quiroz

et al.

Published: April 17, 2025

Mutations fuel evolution while also causing diseases like cancer. Epigenome-targeted DNA repair can help organisms protect important genomic regions from mutation. However, the adaptive value, mechanistic diversity, and of epigenome-targeted systems across tree life remain unresolved. Here, we investigated histone reader domains fused to protein MSH6 (MutS Homolog 6) over 4,000 eukaryotes. We uncovered a paradigmatic example convergent evolution: has independently acquired distinct domains; PWWP (metazoa) Tudor (plants), previously shown target modifications in active genes humans (H3K36me3) Arabidopsis (H3K4me1). Conservation shows signatures natural selection, particularly for amino acids that bind specific modifications. Species have gained or retained readers tend larger genome sizes, especially marked by significantly more introns genic regions. These patterns support previous theoretical predictions about co-evolution architectures mutation rate heterogeneity. The implications evolution, health, mutational origins genetic diversity life.

Language: Английский

Citations

0
Convergent evolution of epigenome recruited DNA repair across the Tree of Life DOI Open Access
J. Grey Monroe, Chaehee Lee, Daniela Quiroz

et al.

Published: April 17, 2025

Mutations fuel evolution while also causing diseases like cancer. Epigenome-targeted DNA repair can help organisms protect important genomic regions from mutation. However, the adaptive value, mechanistic diversity, and of epigenome-targeted systems across tree life remain unresolved. Here, we investigated histone reader domains fused to protein MSH6 (MutS Homolog 6) over 4,000 eukaryotes. We uncovered a paradigmatic example convergent evolution: has independently acquired distinct domains; PWWP (metazoa) Tudor (plants), previously shown target modifications in active genes humans (H3K36me3) Arabidopsis (H3K4me1). Conservation shows signatures natural selection, particularly for amino acids that bind specific modifications. Species have gained or retained readers tend larger genome sizes, especially marked by significantly more introns genic regions. These patterns support previous theoretical predictions about co-evolution architectures mutation rate heterogeneity. The implications evolution, health, mutational origins genetic diversity life.

Language: Английский

Citations

0
Convergent evolution of epigenome recruited DNA repair across the Tree of Life DOI Creative Commons
J. Grey Monroe, Chaehee Lee, Daniela Quiroz

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 18, 2024

Abstract Mutations fuel evolution while also causing diseases like cancer. Epigenome-targeted DNA repair can help organisms protect important genomic regions from mutation. However, the adaptive value, mechanistic diversity, and of epigenome-targeted systems across tree life remain unresolved. Here, we investigated histone reader domains fused to protein MSH6 (MutS Homolog 6) over 4,000 eukaryotes. We uncovered a paradigmatic example convergent evolution: has independently acquired distinct domains; PWWP (metazoa) Tudor (plants), previously shown target modifications in active genes humans (H3K36me3) Arabidopsis (H3K4me1). Conservation shows signatures natural selection, particularly for amino acids that bind specific modifications. Species have gained or retained readers tend larger genome sizes, especially marked by significantly more introns genic regions. These patterns support previous theoretical predictions about co-evolution architectures mutation rate heterogeneity. The implications evolution, health, mutational origins genetic diversity life. Short Summary Fusions between mismatch evolved multiple times Eukaryotes show evidence providing insight into forces shaping

Language: Английский

Citations

0