Zebrafish as a model for human epithelial pathology

Laboratory Animal Research, Journal Year: 2025, Volume and Issue: 41(1)

Published: Feb. 3, 2025

Abstract Zebrafish ( Danio rerio ) have emerged as an influential model for studying human epithelial pathology, particularly because of their genetic similarity to humans and unique physiological traits. This review explores the structural functional homology between zebrafish tissues in organs, such gastrointestinal system, liver, kidneys. possess significant cellular with mammals, which facilitates investigation various diseases, including inflammatory bowel disease, nonalcoholic fatty liver polycystic kidney disease. The advantages using a organism include rapid external development, ease manipulation, advanced imaging capabilities, allowing real-time observation disease processes. However, limitations exist, concerning lack organs potential incomplete phenocopy conditions. Despite these challenges, ongoing research adult promises enhance our understanding mechanisms regenerative By revealing similarities differences cell function pathways, this highlights value translational advancing knowledge health developing targeted therapies.

Language: Английский

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Adaptive cellular evolution in the intestinal tracts of hyperdiverse African cichlid fishes

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 1, 2024

Adaptations related to how nutrients are acquired and processed play a central role in the colonization of novel ecological niches and, therefore, organismal diversification. While evolution feeding structures has been studied extensively this context, nature dietary adaptations digestive tract remains largely unexplored. Here, we investigate cellular molecular basis massive radiation cichlid fishes Lake Tanganyika using comprehensive single-cell transcriptomic data derived from intestines 24 endemic species with distinct habitats diets. We show that, at level, primarily driven by anterior enterocytes, that both relative abundance gene expression profiles these cells have evolved response rapid specializations. These rapidly evolving cell population-specific genes, suggesting alterations epithelial specification programs makeup promote

Language: Английский

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Balancing microbial composition through diet

eLife, Journal Year: 2024, Volume and Issue: 13

Published: Nov. 20, 2024

A reciprocal interaction between gut bacteria and cells affects protein absorption in the host.

Language: Английский

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