
NeuroImage, Journal Year: 2025, Volume and Issue: unknown, P. 121258 - 121258
Published: May 1, 2025
In recent years, mapping tissue microstructure in the cortex using high gradient diffusion MRI has received growing attention. The Soma And Neurite Density Imaging (SANDI) explicitly models soma compartment assuming impermeable membranes. As such, it does not account for time dependence due to water exchange estimated microstructural properties, as neurites gray matter are much less myelinated than white matter. this work, we performed a systematic evaluation of an extended SANDI model vivo human cortical that accounts effects between neurite and extracellular compartments anisotropic Kärger model. We refer SANDIX, adapting nomenclature from previous publications. original model, is modeled sphere smaller surface-to-volume ratio compared compartment. A Monte Carlo simulation study was examine sensitivity SANDIX radii, fractions, times. results indicate proposed framework can effect provide measures intra-soma intra-neurite signal fractions without spurious time-dependence parameters, whereas measured times need be interpreted with caution. then applied data acquired 13 healthy adults on 3-Tesla Connectome scanner equipped 300 mT/m gradients. exhibited patterns were consistent corresponding anatomical characteristics both particular, distinct differentiated two types. Our show approach high-gradient achieves brain effects. This potentially provides more appropriate description improving interpretation future neurobiological studies.
Language: Английский