Homeostasis After Injury: How Intertwined Inference and Control Underpin Post-Injury Pain and Behaviour DOI Creative Commons
Pranav Mahajan,

Peter S. Dayan,

Ben Seymour

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 6, 2025

Abstract Injuries are an unfortunate but inevitable fact of life, leading to evolutionary mandate for powerful homeostatic processes recovery and recuperation. The physiological responses the body immune system must be coordinated with behaviour allow protected time this happen, prevent further damage affected bodily parts. Reacting appropriately requires internal control that represents nature state injury specifies withholds actions accordingly. We bring formal uncertainties embodied in into framework a partially observable Markov decision process (POMDP). discuss nociceptive phenomena light analysis, noting particularly paradoxical behaviours associated investigation, propensity transitions from normative, tonic, pathological, chronic, pain states. Importantly, these simulation results provide quantitative account enable us sketch much needed roadmap future theoretical experimental studies on injury, tonic pain, transition chronic pain. Ultimately, we seek novel ways target

Language: Английский

Homeostasis After Injury: How Intertwined Inference and Control Underpin Post-Injury Pain and Behaviour DOI Creative Commons
Pranav Mahajan,

Peter S. Dayan,

Ben Seymour

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 6, 2025

Abstract Injuries are an unfortunate but inevitable fact of life, leading to evolutionary mandate for powerful homeostatic processes recovery and recuperation. The physiological responses the body immune system must be coordinated with behaviour allow protected time this happen, prevent further damage affected bodily parts. Reacting appropriately requires internal control that represents nature state injury specifies withholds actions accordingly. We bring formal uncertainties embodied in into framework a partially observable Markov decision process (POMDP). discuss nociceptive phenomena light analysis, noting particularly paradoxical behaviours associated investigation, propensity transitions from normative, tonic, pathological, chronic, pain states. Importantly, these simulation results provide quantitative account enable us sketch much needed roadmap future theoretical experimental studies on injury, tonic pain, transition chronic pain. Ultimately, we seek novel ways target

Language: Английский

Citations

0