Principles of GABAergic signaling in developing cortical network dynamics

Cell Reports, Journal Year: 2022, Volume and Issue: 38(13), P. 110568 - 110568

Published: March 1, 2022

GABAergic signaling provides inhibitory stabilization and spatiotemporally coordinates the firing of recurrently connected excitatory neurons in mature cortical circuits. Inhibition thus enables self-generated neuronal activity patterns that underlie various aspects sensation cognition. In this review, we aim to provide a conceptual framework describing how when GABA-releasing interneurons acquire their network functions during development. Focusing on developing visual neocortex hippocampus mice rats vivo, hypothesize at onset patterned activity, glutamatergic are stable by themselves is not yet functional. We review important milestones development illustrate cell-type-specific strengthening synaptic inhibition toward eye opening shapes dynamics allows cortex progressively disengage from extra-cortical drive. translate human discuss clinical implications for treatment neonatal seizures.

Language: Английский

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A circuit mechanism for independent modulation of excitatory and inhibitory firing rates after sensory deprivation

Proceedings of the National Academy of Sciences, Journal Year: 2022, Volume and Issue: 119(32)

Published: Aug. 4, 2022

Diverse interneuron subtypes shape sensory processing in mature cortical circuits. During development, deprivation evokes powerful synaptic plasticity that alters circuitry, but how different inhibitory modulate circuit dynamics response to this remains unclear. We investigate deprivation-induced changes affect excitatory and firing rates a microcircuit model of the cortex with multiple subtypes. find single subtype (parvalbumin-expressing [PV]), can only be comodulated—increased or decreased together. To explain experimentally observed independent modulation, whereby one rate increases other decreases, requires strong feedback from second (somatostatin-expressing [SST]). Our applies visual somatosensory cortex, suggesting general mechanism across cortices. Therefore, we provide mechanistic explanation for differential role regulating rates, contributing already diverse roles they serve cortex.

Language: Английский

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Volume-transmitted GABA waves pace epileptiform rhythms in the hippocampal network

Current Biology, Journal Year: 2023, Volume and Issue: 33(7), P. 1249 - 1264.e7

Published: March 14, 2023

Mechanisms that entrain and pace rhythmic epileptiform discharges remain debated. Traditionally, the quest to understand them has focused on interneuronal networks driven by synaptic GABAergic connections. However, synchronized could also trigger transient elevations of extracellular GABA across tissue volume, thus raising tonic conductance (Gtonic) extrasynaptic receptors in multiple cells. Here, we monitor hippocampal slices using patch-clamp "sniffer" a novel optical sensor, showing periodic are preceded transient, region-wide waves GABA. Neural network simulations incorporate volume-transmitted signals point cycle GABA-driven inhibition disinhibition underpinning this relationship. We test validate hypothesis simultaneous recordings from neurons selective optogenetic stimulation fast-spiking interneurons. Critically, reducing uptake order decelerate fluctuations—without affecting transmission or resting levels—slows down activity. Our findings unveil key role extrasynaptic, pacing regenerative activity brain networks.

Language: Английский

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Mechanisms underlying reshuffling of visual responses by optogenetic stimulation in mice and monkeys

Neuron, Journal Year: 2023, Volume and Issue: 111(24), P. 4102 - 4115.e9

Published: Oct. 20, 2023

Language: Английский

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Response sub-additivity and variability quenching in visual cortex

Nature reviews. Neuroscience, Journal Year: 2024, Volume and Issue: 25(4), P. 237 - 252

Published: Feb. 19, 2024

Language: Английский

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