C. elegans foraging as a model for understanding the neuronal basis of decision-making DOI Creative Commons
Jessica A Haley, Sreekanth H. Chalasani

Cellular and Molecular Life Sciences, Journal Year: 2024, Volume and Issue: 81(1)

Published: June 8, 2024

Animals have evolved to seek, select, and exploit food sources in their environment. Collectively termed foraging, these ubiquitous behaviors are necessary for animal survival. As a foundation understanding behavioral ecologists established early theoretical mathematical frameworks which been subsequently refined supported by field laboratory studies of foraging animals. These simple models sought explain how animals decide strategies employ when locating food, what items consume, explore the environment new sources. decisions involve integration prior experience with multimodal sensory information about animal's current internal state. We suggest that nematode Caenorhabditis elegans is well-suited high-resolution analysis complex goal-oriented such as foraging. focus our discussion on highlighting C. bacteria summarize known underlying neuronal molecular pathways. Broadly, we this model system can provide mechanistic decision-making present additional avenues advancing processes.

Language: Английский

The emergence and influence of internal states DOI Creative Commons
Steven W. Flavell, Nadine Gogolla, Matthew Lovett-Barron

et al.

Neuron, Journal Year: 2022, Volume and Issue: 110(16), P. 2545 - 2570

Published: May 27, 2022

Language: Английский

Citations

139
Brain-wide representations of behavior spanning multiple timescales and states in C. elegans DOI Creative Commons

Adam A. Atanas,

Jung Soo Kim, Ziyu Wang

et al.

Cell, Journal Year: 2023, Volume and Issue: 186(19), P. 4134 - 4151.e31

Published: Aug. 21, 2023

Changes in an animal's behavior and internal state are accompanied by widespread changes activity across its brain. However, how neurons the brain encode this is impacted poorly understood. We recorded brain-wide diverse motor programs of freely moving C. elegans built probabilistic models that explain each neuron encodes quantitative behavioral features. By determining identities neurons, we created atlas defined classes connectome behavior. Many have conjunctive representations multiple behaviors. Moreover, although many current actions, others integrate recent actions. behavior, identify these flexible nodes connectome. Our results provide a global map cell types

Language: Английский

Citations

47
Unraveling the dynamics of dopamine release and its actions on target cells DOI Creative Commons
Tanya Sippy, Nicolas X. Tritsch

Trends in Neurosciences, Journal Year: 2023, Volume and Issue: 46(3), P. 228 - 239

Published: Jan. 10, 2023

Language: Английский

Citations

44
Learning hydrodynamic equations for active matter from particle simulations and experiments DOI Creative Commons

Rohit Supekar,

Boya Song,

Alasdair Hastewell

et al.

Proceedings of the National Academy of Sciences, Journal Year: 2023, Volume and Issue: 120(7)

Published: Feb. 10, 2023

Recent advances in high-resolution imaging techniques and particle-based simulation methods have enabled the precise microscopic characterization of collective dynamics various biological engineered active matter systems. In parallel, data-driven algorithms for learning interpretable continuum models shown promising potential recovery underlying partial differential equations (PDEs) from data. By contrast, macroscopic hydrodynamic directly experiments or particle simulations remains a major challenge, especially when are not known priori analytic coarse graining fails, as often is case nondilute heterogeneous Here, we present framework that leverages spectral basis representations sparse regression to discover PDE experimental data, while incorporating relevant physical symmetries. We illustrate practical through range applications, chiral model mimicking nonidentical swimming cells recent microroller schooling fish. all these cases, our scheme learns reproduce self-organized observed experiments. This inference makes it possible measure large number parameters parallel video

Language: Английский

Citations

43
Whole-organism behavioral profiling reveals a role for dopamine in state-dependent motor program coupling in C. elegans DOI Creative Commons
Nathan Cermak,

Stephanie Yu,

Rebekah Clark

et al.

eLife, Journal Year: 2020, Volume and Issue: 9

Published: June 8, 2020

Animal behaviors are commonly organized into long-lasting states that coordinately impact the generation of diverse motor outputs such as feeding, locomotion, and grooming. However, neural mechanisms coordinate these distinct programs remain poorly understood. Here, we examine how nematode C. elegans coupled together across behavioral states. We describe a new imaging platform permits automated, simultaneous quantification each main over hours or days. Analysis whole-organism profiles shows change animals switch Utilizing genetics, optogenetics, calcium imaging, identify role for dopamine in coupling locomotion egg-laying These results provide insights throughout an organism coordinated suggest neuromodulators like can couple circuits state-dependent manner.

Language: Английский

Citations

82
Microplastics and Their Impact on Reproduction—Can we Learn From the C. elegans Model? DOI Creative Commons

Elysia Jewett,

Gareth Arnott, Lisa Connolly

et al.

Frontiers in Toxicology, Journal Year: 2022, Volume and Issue: 4

Published: March 24, 2022

Biologically active environmental pollutants have significant impact on ecosystems, wildlife, and human health. Microplastic (MP) nanoplastic (NP) particles are that present in the terrestrial aquatic ecosystems at virtually every level of food chain. Moreover, recently, airborne microplastic been shown to reach potentially damage respiratory systems. Microplastics nanoplastics cause increased oxidative stress, inflammation, altered metabolism leading cellular damage, which ultimately affects tissue organismal homeostasis numerous animal species cells. However, full these plastic living organisms is not completely understood. The ability MPs/NPs carry contaminants, toxic chemicals, pesticides, bioactive compounds, such as endocrine disrupting an additional risk This review will discusses current knowledge pathways by reproduction reproductive behaviors from whole organism down plastics-induced defects, while also identifying gaps regarding mechanisms action. Furthermore, we suggest nematode

Language: Английский

Citations

65
Serotonin and dopamine modulate aging in response to food odor and availability DOI Creative Commons
Hillary Miller, Shijiao Huang,

Elizabeth S. Dean

et al.

Nature Communications, Journal Year: 2022, Volume and Issue: 13(1)

Published: June 7, 2022

Abstract An organism’s ability to perceive and respond changes in its environment is crucial for health survival. Here we reveal how the most well-studied longevity intervention, dietary restriction, acts in-part through a cell non-autonomous signaling pathway that inhibited by presence of attractive smells. Using an intestinal reporter key gene induced restriction but suppressed smells, identify three compounds block food odor effects C. elegans , thereby increasing as mimetics. These clearly implicate serotonin dopamine limiting lifespan response odor. We further chemosensory neuron likely perceives odor, enteric signals receptor 5-HT1A/SER-4, dopaminergic DRD2/DOP-3. Aspects this are conserved D. melanogaster . Thus, blocking antagonism or receptors plausible approach mimic benefits restriction.

Language: Английский

Citations

44
Dissecting the functional organization of the C. elegans serotonergic system at whole-brain scale DOI Creative Commons
Ugur Dag, Ijeoma Nwabudike,

Di Kang

et al.

Cell, Journal Year: 2023, Volume and Issue: 186(12), P. 2574 - 2592.e20

Published: May 15, 2023

Serotonin influences many aspects of animal behavior. But how serotonin acts on its diverse receptors across the brain to modulate global activity and behavior is unknown. Here, we examine release in C. elegans alters brain-wide induce foraging behaviors, like slow locomotion increased feeding. Comprehensive genetic analyses identify three core (MOD-1, SER-4, LGC-50) that upon others (SER-1, SER-5, SER-7) interact with them this SER-4 induces behavioral responses sudden increases release, whereas MOD-1 persistent release. Whole-brain imaging reveals widespread serotonin-associated dynamics, spanning networks. We map all sites receptor expression connectome, which, together synaptic connectivity, helps predict which neurons show activity. These results reveal at defined a connectome

Language: Английский

Citations

39
Versatility of Caenorhabditis elegans as a Model Organism for Evaluating Foodborne Neurotoxins and Food Bioactive Compounds in Nutritional Neuroscience DOI
Isaac A. Adedara, Grazielle Castagna Cezimbra Weis, Camila Sant’Anna Monteiro

et al.

Molecular Neurobiology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 25, 2025

Language: Английский

Citations

1
Behavioral States DOI Open Access
Steven W. Flavell, David M. Raizen, Young‐Jai You

et al.

Genetics, Journal Year: 2020, Volume and Issue: 216(2), P. 315 - 332

Published: Oct. 1, 2020

' behavioral states, like those of other animals, are shaped by its immediate environment, past experiences, and internal factors. We here review the literature on

Language: Английский

Citations

68