Identification of astroglia-like cardiac nexus glia that are critical regulators of cardiac development and function DOI Creative Commons

Nina L. Kikel-Coury,

Jacob P. Brandt, Isabel A. Correia

et al.

PLoS Biology, Journal Year: 2021, Volume and Issue: 19(11), P. e3001444 - e3001444

Published: Nov. 18, 2021

Glial cells are essential for functionality of the nervous system. Growing evidence underscores importance astrocytes; however, analogous astroglia in peripheral organs poorly understood. Using confocal time-lapse imaging, fate mapping, and mutant genesis a zebrafish model, we identify neural crest-derived glial cell, termed nexus glia, which utilizes Meteorin signaling via Jak/Stat3 to drive differentiation regulate heart rate rhythm. Nexus glia labeled with gfap, glast, glutamine synthetase, markers that typically denote cells. Further, analysis single-cell sequencing datasets human murine hearts across ages reveals astrocyte-like cells, confirm through multispecies approach. We show cardiac at outflow tract critical regulators both sympathetic parasympathetic These data establish crucial role on homeostasis provide description PNS.

Language: Английский

Characterizing the phenotype of pre-bötzinger complex neurons in rats DOI Creative Commons
Angela A. Connelly, Jaspreet K. Bassi,

Joshua J. Voger

et al.

Neuroscience, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

Citations

0
Respiratory Sinus Arrhythmia: Physiological Mechanisms and Relationship with Systemic Blood Pressure Fluctuations DOI
О. Л. Виноградова, А. С. Боровик,

R. Yu. Zhedyaev

et al.

Human Physiology, Journal Year: 2024, Volume and Issue: 50(3), P. 276 - 284

Published: June 1, 2024

Language: Английский

Citations

3
Redefining respiratory sinus arrhythmia as respiratory heart rate variability: an international Expert Recommendation for terminological clarity DOI
Clément Menuet, Alona Ben‐Tal, Ambre Linossier

et al.

Nature Reviews Cardiology, Journal Year: 2025, Volume and Issue: unknown

Published: May 6, 2025

Language: Английский

Citations

0
Rostral ventrolateral medulla, retropontine region and autonomic regulations DOI
Patrice G. Guyenet, Ruth L. Stornetta

Autonomic Neuroscience, Journal Year: 2021, Volume and Issue: 237, P. 102922 - 102922

Published: Nov. 19, 2021

Language: Английский

Citations

23
Identification of astroglia-like cardiac nexus glia that are critical regulators of cardiac development and function DOI Creative Commons

Nina L. Kikel-Coury,

Jacob P. Brandt, Isabel A. Correia

et al.

PLoS Biology, Journal Year: 2021, Volume and Issue: 19(11), P. e3001444 - e3001444

Published: Nov. 18, 2021

Glial cells are essential for functionality of the nervous system. Growing evidence underscores importance astrocytes; however, analogous astroglia in peripheral organs poorly understood. Using confocal time-lapse imaging, fate mapping, and mutant genesis a zebrafish model, we identify neural crest-derived glial cell, termed nexus glia, which utilizes Meteorin signaling via Jak/Stat3 to drive differentiation regulate heart rate rhythm. Nexus glia labeled with gfap, glast, glutamine synthetase, markers that typically denote cells. Further, analysis single-cell sequencing datasets human murine hearts across ages reveals astrocyte-like cells, confirm through multispecies approach. We show cardiac at outflow tract critical regulators both sympathetic parasympathetic These data establish crucial role on homeostasis provide description PNS.

Language: Английский

Citations

21