bioRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2024,
Volume and Issue:
unknown
Published: May 1, 2024
Abstract
Neuronal
processing
of
external
sensory
input
is
shaped
by
internally-generated
top-down
information.
In
the
neocortex,
projections
predominantly
target
layer
1,
which
contains
NDNF-expressing
interneurons,
nestled
between
dendrites
pyramidal
cells
(PCs).
Here,
we
propose
that
NDNF
interneurons
shape
cortical
computations
presynap-tically
inhibiting
outputs
somatostatin-expressing
(SOM)
via
GABAergic
volume
transmission
in
1.
Whole-cell
patch
clamp
recordings
from
genetically
identified
INs
1
auditory
cortex
show
SOM-to-NDNF
synapses
are
indeed
modulated
ambient
GABA.
a
microcircuit
model,
then
demonstrate
this
mechanism
can
control
inhibition
layer-specific
way
and
introduces
competition
for
dendritic
SOM
interneurons.
This
mediated
unique
mutual
motif
synaptic
dynamically
prioritise
different
inhibitory
signals
to
PC
dendrite.
thereby
information
flow
redistributing
fast
slow
timescales
gating
sources
inhibition,
as
exemplified
predictive
coding
application.
work
corroborates
ideally
suited
within
Processes,
Journal Year:
2023,
Volume and Issue:
11(3), P. 661 - 661
Published: Feb. 22, 2023
Changes
in
the
pore
water
pressure
of
soil
are
essential
factors
that
affect
movement
structures
during
and
after
construction
terms
stability
safety.
Soil
permeability
represents
quantity
transferred
using
pressure.
However,
these
changes
cannot
be
easily
identified
require
considerable
time
money.
This
study
predicted
evaluated
coefficient
a
multiple
regression
(MR)
model,
adaptive
network-based
fuzzy
inference
system
(ANFIS),
general
deep
neural
network
(DNN)
DNN
dendrite
concept
(DNN−T,
which
was
proposed
this
study).
The
void
ratio,
unit
weight,
particle
size
were
obtained
from
164
undisturbed
samples
collected
embankments
reservoirs
South
Korea
as
input
variables
for
aforementioned
models.
data
used
included
seven
variables,
ratios
training
to
validation
randomly
extracted,
such
6:4,
7:3,
8:2,
used.
analysis
results
each
model
showed
median
correlation
r
=
0.6
or
less
low
efficiency
Nash–Sutcliffe
(NSE)
0.35
result
predicting
MR
ANFIS.
DNN−T
both
have
good
performance,
with
strong
0.75
higher.
Evidently,
performance
r,
NSE,
root
mean
square
error
(RMSE)
improved
more
than
DNN.
difference
between
absolute
percent
(MAPE)
small
(11%).
Regarding
ratio
verification
data,
7:3
8:2
better
compared
6:4
indicators,
RMSE,
MAPE.
We
assumed
phenomenon
caused
by
thinking
layer.
shows
DNN−T,
structure
DNN,
is
an
alternative
estimating
safety
inspection
sites
excellent
methodology
can
save
budget.
bioRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2023,
Volume and Issue:
unknown
Published: May 12, 2023
Abstract
Understanding
the
variability
of
environment
is
essential
to
function
in
everyday
life.
The
brain
must
hence
take
uncertainty
into
account
when
updating
its
internal
model
world.
basis
for
are
prediction
errors
that
arise
from
a
difference
between
current
and
new
sensory
experiences.
Although
error
neurons
have
been
identified
layer
2/3
diverse
areas,
how
modulates
these
learning
is,
however,
unclear.
Here,
we
use
normative
approach
derive
should
modulate
postulate
represent
uncertainty-modulated
(UPE).
We
further
hypothesise
circuit
calculates
UPE
through
subtractive
divisive
inhibition
by
different
inhibitory
cell
types.
By
implementing
calculation
UPEs
microcircuit
model,
show
types
can
compute
means
variances
stimulus
distribution.
With
local
activity-dependent
plasticity
rules,
computations
be
learned
context-dependently,
allow
upcoming
stimuli
their
Finally,
mechanism
enables
an
organism
optimise
strategy
via
adaptive
rates.
PLoS Computational Biology,
Journal Year:
2024,
Volume and Issue:
20(3), P. e1011921 - e1011921
Published: March 7, 2024
In
an
ever-changing
visual
world,
animals’
survival
depends
on
their
ability
to
perceive
and
respond
rapidly
changing
motion
cues.
The
primary
cortex
(V1)
is
at
the
forefront
of
this
sensory
processing,
orchestrating
neural
responses
perturbations
in
flow.
However,
underlying
mechanisms
that
lead
distinct
cortical
such
remain
enigmatic.
study,
our
objective
was
uncover
dynamics
govern
V1
neurons’
flow
using
a
biologically
realistic
computational
model.
By
subjecting
model
sudden
changes
input,
we
observed
opposing
excitatory
layer
2/3
(L2/3)
neurons,
namely,
depolarizing
hyperpolarizing
responses.
We
found
segregation
primarily
driven
by
competition
between
external
input
recurrent
inhibition,
particularly
within
L2/3
L4.
This
division
not
L5/6
suggesting
more
prominent
role
for
inhibitory
processing
upper
layers.
Our
findings
share
similarities
with
recent
experimental
studies
focusing
influence
top-down
bottom-up
inputs
mouse
during
perturbations.
bioRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2023,
Volume and Issue:
unknown
Published: Dec. 14, 2023
Abstract
At
any
moment,
our
brains
receive
a
stream
of
sensory
stimuli
arising
from
the
world
we
interact
with.
Simultaneously,
neural
circuits
are
shaped
by
feedback
signals
carrying
predictions
about
same
inputs
experience.
Those
feedforward
and
often
do
not
perfectly
match.
Thus,
have
challenging
task
integrating
these
conflicting
streams
information
according
to
their
reliabilities.
However,
how
keep
track
both
stimulus
prediction
uncertainty
is
well
understood.
Here,
propose
network
model
whose
core
hierarchical
prediction-error
circuit.
We
show
that
can
estimate
variance
using
activity
negative
positive
neurons.
In
line
with
previous
hypotheses,
demonstrate
rely
strongly
on
if
perceived
noisy
underlying
generative
process,
is,
environment
stable.
Moreover,
modulate
at
onset
new
stimulus,
even
this
reliable.
network,
estimation,
and,
hence,
much
predictions,
be
influenced
perturbing
intricate
interplay
different
inhibitory
interneurons.
We,
therefore,
investigate
contribution
those
interneurons
weighting
inputs.
Finally,
linked
biased
perception
unravel
contribute
contraction
bias.
bioRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2024,
Volume and Issue:
unknown
Published: May 1, 2024
Abstract
Neuronal
processing
of
external
sensory
input
is
shaped
by
internally-generated
top-down
information.
In
the
neocortex,
projections
predominantly
target
layer
1,
which
contains
NDNF-expressing
interneurons,
nestled
between
dendrites
pyramidal
cells
(PCs).
Here,
we
propose
that
NDNF
interneurons
shape
cortical
computations
presynap-tically
inhibiting
outputs
somatostatin-expressing
(SOM)
via
GABAergic
volume
transmission
in
1.
Whole-cell
patch
clamp
recordings
from
genetically
identified
INs
1
auditory
cortex
show
SOM-to-NDNF
synapses
are
indeed
modulated
ambient
GABA.
a
microcircuit
model,
then
demonstrate
this
mechanism
can
control
inhibition
layer-specific
way
and
introduces
competition
for
dendritic
SOM
interneurons.
This
mediated
unique
mutual
motif
synaptic
dynamically
prioritise
different
inhibitory
signals
to
PC
dendrite.
thereby
information
flow
redistributing
fast
slow
timescales
gating
sources
inhibition,
as
exemplified
predictive
coding
application.
work
corroborates
ideally
suited
within