Nature Neuroscience,
Journal Year:
2023,
Volume and Issue:
26(11), P. 1916 - 1928
Published: Oct. 9, 2023
The
neocortex
and
cerebellum
interact
to
mediate
cognitive
functions.
It
remains
unknown
how
the
two
structures
organize
into
functional
networks
specific
behaviors.
Here
we
delineate
activity
supporting
motor
planning
in
relation
mesoscale
cortico-cerebellar
connectome.
In
mice
directional
licking
based
on
short-term
memory,
preparatory
instructing
future
movement
depends
anterior
lateral
cortex
(ALM)
cerebellum.
Transneuronal
tracing
revealed
divergent
largely
open-loop
connectivity
between
ALM
distributed
regions
of
A
cerebellum-wide
survey
neuronal
enriched
hotspot
with
conjunctive
input-output
ALM.
Perturbation
experiments
show
that
conjunction
were
required
for
maintaining
correct
subsequent
movement.
Other
cerebellar
contributed
little
despite
input
or
output
These
results
identify
a
loop
suggest
selectively
establishes
reciprocal
communications
orchestrate
planning.
Science,
Journal Year:
2020,
Volume and Issue:
370(6523)
Published: Dec. 18, 2020
How
have
complex
brains
evolved
from
simple
circuits?
Here
we
investigated
brain
region
evolution
at
cell-type
resolution
in
the
cerebellar
nuclei,
output
structures
of
cerebellum.
Using
single-nucleus
RNA
sequencing
mice,
chickens,
and
humans,
as
well
STARmap
spatial
transcriptomic
analysis
whole-central
nervous
system
projection
tracing,
identified
a
conserved
set
containing
two
region-specific
excitatory
neuron
classes
three
region-invariant
inhibitory
classes.
This
constitutes
an
archetypal
nucleus
that
was
repeatedly
duplicated
to
form
new
regions.
The
cell
class
preferentially
funnels
information
lateral
frontal
cortices
mice
becomes
predominant
massively
expanded
human
nucleus.
Our
data
suggest
model
by
duplication
divergence
entire
sets.
Annual Review of Neuroscience,
Journal Year:
2021,
Volume and Issue:
44(1), P. 335 - 357
Published: March 26, 2021
The
large
number
of
ion
channels
found
in
all
nervous
systems
poses
fundamental
questions
concerning
how
the
characteristic
intrinsic
properties
single
neurons
are
determined
by
specific
subsets
they
express.
All
display
many
different
with
overlapping
voltage-
and
time-dependent
properties.
We
speculate
that
these
promote
resilience
neuronal
function.
Individual
same
cell
type
show
variability
channel
conductance
densities
even
though
can
generate
reliable
similar
behavior.
This
complicates
a
simple
assignment
function
to
any
is
associated
variable
responses
perturbations,
deletions,
pharmacological
manipulation.
Ion
genes
often
strong
positively
correlated
expression,
which
may
result
from
molecular
developmental
rules
determine
expressed
given
type.
Respiration
is
a
brain
function
on
which
our
lives
essentially
depend.
Control
of
respiration
ensures
that
the
frequency
and
depth
breathing
adapt
continuously
to
metabolic
needs.
In
addition,
respiratory
control
network
has
organize
muscular
synergies
integrate
ventilation
with
posture
body
movement.
Finally,
coupled
cardiovascular
emotion.
Here,
we
argue
can
handle
this
all
by
integrating
brainstem
central
pattern
generator
circuit
in
larger
also
comprises
cerebellum.
Although
currently
not
generally
recognized
as
center,
cerebellum
well
known
for
its
coordinating
modulating
role
motor
behavior,
autonomic
nervous
system.
review,
discuss
regions
involved
respiration,
their
anatomical
functional
interactions.
We
how
sensory
feedback
result
adaptation
these
mechanisms
be
compromised
various
neurological
psychological
disorders.
demonstrate
generators
are
part
integrated
regions.
Journal of Neuroscience,
Journal Year:
2023,
Volume and Issue:
43(45), P. 7554 - 7564
Published: Nov. 8, 2023
The
cerebellum,
traditionally
associated
with
motor
coordination
and
balance,
also
plays
a
crucial
role
in
various
aspects
of
higher-order
function
dysfunction.
Emerging
research
has
shed
light
on
the
cerebellum's
broader
contributions
to
cognitive,
emotional,
reward
processes.
influence
autonomic
further
highlights
its
significance
regulating
motivational
emotional
states.
Perturbations
cerebellar
development
have
been
implicated
neurodevelopmental
disorders,
including
autism
spectrum
disorder
attention
deficit
hyperactivity
disorder.
An
increasing
appreciation
for
neuropsychiatric
symptoms
that
arise
from
dysfunction
underscores
importance
elucidating
circuit
mechanisms
underlie
complex
interactions
between
cerebellum
other
brain
regions
comprehensive
understanding
behavior.
By
briefly
discussing
new
advances
mapping
affective,
autonomic,
social
processing
reviewing
neuropathology
beyond
domain,
this
Mini-Symposium
review
aims
provide
broad
perspective
intersections
limbic
health
disease.
The Cerebellum,
Journal Year:
2023,
Volume and Issue:
23(2), P. 620 - 677
Published: Feb. 13, 2023
Abstract
The
cerebellum
is
a
key
player
in
many
brain
functions
and
major
topic
of
neuroscience
research.
However,
the
cerebellar
nuclei
(CN),
main
output
structures
cerebellum,
are
often
overlooked.
This
neglect
because
research
on
typically
focuses
cortex
tends
to
treat
CN
as
relatively
simple
conveying
an
inverted
signal
from
rest
brain.
In
this
review,
by
adopting
nucleocentric
perspective
we
aim
rectify
impression.
First,
describe
anatomy
modularity
comprehensively
integrate
architecture
with
its
highly
organized
but
complex
afferent
efferent
connectivity.
followed
novel
classification
specific
neuronal
classes
comprise
speculate
implications
structure
physiology
for
our
understanding
adult
function.
Based
thorough
review
literature
provide
comprehensive
overview
embryonic
development
and,
comparing
various
chordate
clades,
propose
interpretation
evolution.
Despite
their
critical
importance
function,
clinical
intriguingly
few,
if
any,
neurological
disorders
appear
primarily
affect
CN.
To
highlight
curious
anomaly,
encourage
future
interpretations,
build
brief
syndromes
which
currently
implicated.
Finally,
summarize
perspectives
that
view
brings,
move
outstanding
issues
biology
limelight,
roadmap
questions
need
be
answered
order
create
integrated
model
structure,
development,
