Wide-spread brain activation and reduced CSF flow during avian REM sleep DOI Creative Commons
Gianina Ungurean, Mehdi Behroozi,

Leonard Böger

et al.

Nature Communications, Journal Year: 2023, Volume and Issue: 14(1)

Published: June 5, 2023

Abstract Mammalian sleep has been implicated in maintaining a healthy extracellular environment the brain. During wakefulness, neuronal activity leads to accumulation of toxic proteins, which glymphatic system is thought clear by flushing cerebral spinal fluid (CSF) through In mice, this process occurs during non-rapid eye movement (NREM) sleep. humans, ventricular CSF flow also shown increase NREM sleep, as visualized using functional magnetic resonance imaging (fMRI). The link between and not studied birds before. Using fMRI naturally sleeping pigeons, we show that REM paradoxical state with wake-like brain activity, accompanied activation regions involved processing visual information, including optic flight. We further demonstrate increases relative but drops sharply Consequently, functions linked might come at expense waste clearance

Language: Английский

Fluid transport in the brain DOI
Martin Kaag Rasmussen, Humberto Mestre, Maiken Nedergaard

et al.

Physiological Reviews, Journal Year: 2021, Volume and Issue: 102(2), P. 1025 - 1151

Published: May 5, 2021

The brain harbors a unique ability to, figuratively speaking, shift its gears. During wakefulness, the is geared fully toward processing information and behaving, while homeostatic functions predominate during sleep. blood-brain barrier establishes stable environment that optimal for neuronal function, yet imposes physiological problem; transcapillary filtration forms extracellular fluid in other organs reduced to minimum brain. Consequently, depends on special [the cerebrospinal (CSF)] flushed into along perivascular spaces created by astrocytic vascular endfeet. We describe this pathway, coined term glymphatic system, based dependency endfeet their adluminal expression of aquaporin-4 water channels facing CSF-filled spaces. Glymphatic clearance potentially harmful metabolic or protein waste products, such as amyloid-β, primarily active sleep, when drivers, cardiac cycle, respiration, slow vasomotion, together efficiently propel CSF inflow periarterial brain's space contains an abundance proteoglycans hyaluronan, which provide low-resistance hydraulic conduit rapidly can expand shrink sleep-wake cycle. system brain, meets requisites maintain homeostasis similar peripheral organs, considering blood-brain-barrier paths formation egress CSF.

Language: Английский

Citations

331
The glymphatic system: Current understanding and modeling DOI Creative Commons
Tomas Bohr, Poul G. Hjorth, Sebastian C. Holst

et al.

iScience, Journal Year: 2022, Volume and Issue: 25(9), P. 104987 - 104987

Published: Aug. 20, 2022

We review theoretical and numerical models of the glymphatic system, which circulates cerebrospinal fluid interstitial around brain, facilitating solute transport. Models enable hypothesis development predictions transport, with clinical applications including drug delivery, stroke, cardiac arrest, neurodegenerative disorders like Alzheimer's disease. sort existing into broad categories by anatomical function: Perivascular flow, transport in brain parenchyma, interfaces to perivascular spaces, efflux routes, links neuronal activity. Needs opportunities for future work are highlighted wherever possible; new models, expanded novel experiments inform could all have tremendous value advancing field.

Language: Английский

Citations

175
Neuroinflammation, Sleep, and Circadian Rhythms DOI Creative Commons

Mark R. Zielinski,

Allison Gibbons

Frontiers in Cellular and Infection Microbiology, Journal Year: 2022, Volume and Issue: 12

Published: March 22, 2022

Molecules involved in innate immunity affect sleep and circadian oscillators vice versa. Sleep-inducing inflammatory molecules are activated by increased waking activity pathogens. Pathologies that alter molecules, such as traumatic brain injury, cancer, cardiovascular disease, stroke often associated with disturbed electroencephalogram power spectra. Moreover, disorders, insomnia disordered breathing, dysregulation of processes. Inflammatory both the central nervous system periphery can sleep. Inflammation also modulate cerebral vascular hemodynamics which is alterations However, further research needed to determine interactions regulatory clocks. The purpose this review to: 1) describe role cytokines interleukin-1 beta tumor necrosis factor-alpha nucleotide-binding domain leucine-rich repeat protein-3 inflammasomes regulation, 2) discuss relationship between vagus nerve translating signals sleep, 3) present information about during

Language: Английский

Citations

114
Neuroimaging evidence of glymphatic system dysfunction in possible REM sleep behavior disorder and Parkinson’s disease DOI Creative Commons
Xiaoli Si, Tao Guo,

Zhiyun Wang

et al.

npj Parkinson s Disease, Journal Year: 2022, Volume and Issue: 8(1)

Published: April 29, 2022

Alpha-synucleinopathy is postulated to be central both idiopathic rapid eye movement sleep behaviour disorder (iRBD) and Parkinson's disease (PD). Growing evidence suggests an association between the diminished clearance of α-synuclein glymphatic system dysfunction. However, accumulating primarily based on clinical data support dysfunction in patients with iRBD PD currently insufficient. This study aimed use diffusion tensor image analysis along perivascular space (DTI-ALPS) evaluate activity its relationship scores severity possible (piRBDs) those PD. Further, we validated correlation ALPS index prognosis longitudinally. Overall, 168 PD, 119 piRBDs, 129 healthy controls were enroled. Among them, 50 had been longitudinally reexamined. Patients exhibited a lower than piRBDs (P = 0.036), patient groups showed < 0.001 P 0.001). The elevated negatively correlated piRBD subgroups. Moreover, was cognitive decline longitudinal analyses. In conclusion, DTI-ALPS provided neuroimaging PD; however, potential assessing pathological progress α-synucleinopathies as indicator worth verifying. Further development imaging methods for function also warranted.

Language: Английский

Citations

108
Glymphatic influx and clearance are accelerated by neurovascular coupling DOI
Stephanie von Holstein‐Rathlou, Yiming Gan, Michael Giannetto

et al.

Nature Neuroscience, Journal Year: 2023, Volume and Issue: 26(6), P. 1042 - 1053

Published: June 1, 2023

Language: Английский

Citations

107
Neurovascular coupling: motive unknown DOI
Patrick J. Drew

Trends in Neurosciences, Journal Year: 2022, Volume and Issue: 45(11), P. 809 - 819

Published: Aug. 19, 2022

Language: Английский

Citations

96
Sleep cycle-dependent vascular dynamics in male mice and the predicted effects on perivascular cerebrospinal fluid flow and solute transport DOI Creative Commons
Laura Bojarskaite, Alexandra Vallet, Daniel M. Bjørnstad

et al.

Nature Communications, Journal Year: 2023, Volume and Issue: 14(1)

Published: Feb. 20, 2023

Abstract Perivascular spaces are important highways for fluid and solute transport in the brain enabling efficient waste clearance during sleep. However, underlying mechanisms augmenting perivascular flow sleep unknown. Using two-photon imaging of naturally sleeping male mice we demonstrate cycle-dependent vascular dynamics pial arteries penetrating arterioles: slow, large-amplitude oscillations NREM sleep, a vasodilation REM vasoconstriction upon awakening at end cycle microarousals intermediate These mirrored by changes size slow fluctuations reduction an enlargement after By biomechanical modeling that these likely enhance to levels comparable cardiac pulsation-driven oscillations.

Language: Английский

Citations

80
Oxygen imaging of hypoxic pockets in the mouse cerebral cortex DOI
Felix R. M. Beinlich, Antonis Asiminas, Verena Untiet

et al.

Science, Journal Year: 2024, Volume and Issue: 383(6690), P. 1471 - 1478

Published: March 28, 2024

Consciousness is lost within seconds upon cessation of cerebral blood flow. The brain cannot store oxygen, and interruption oxidative phosphorylation fatal minutes. Yet only rudimentary knowledge exists regarding cortical partial oxygen tension (

Language: Английский

Citations

30
Norepinephrine-mediated slow vasomotion drives glymphatic clearance during sleep DOI
Natalie Hauglund, Mie Andersen,

Klaudia Tokarska

et al.

Cell, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

23
New perspectives on the glymphatic system and the relationship between glymphatic system and neurodegenerative diseases DOI Creative Commons
Yujie Sun,

Qiankun Lv,

Junyi Liu

et al.

Neurobiology of Disease, Journal Year: 2025, Volume and Issue: 205, P. 106791 - 106791

Published: Jan. 6, 2025

Neurodegenerative diseases (ND) are characterized by the accumulation of aggregated proteins. The glymphatic system, through its rapid exchange mechanisms between cerebrospinal fluid (CSF) and interstitial (ISF), facilitates movement metabolic substances within brain, serving functions akin to those peripheral lymphatic system. This emerging waste clearance mechanism offers a novel perspective on removal pathological in ND. article elucidates recent discoveries regarding system updates relevant concepts model. It discusses potential roles ND, including Alzheimer's disease (AD), Parkinson's (PD), multiple atrophy (MSA), proposes as therapeutic target for these conditions.

Language: Английский

Citations

2