Current Biology, Journal Year: 2022, Volume and Issue: 33(2), P. 215 - 227.e3
Published: Dec. 16, 2022
Language: Английский
Published: Jan. 6, 2025
The mushroom body (MB) is the center for associative learning in insects. In Drosophila , intersectional split-GAL4 drivers and electron microscopy (EM) connectomes have laid foundation precise interrogation of MB neural circuits. However, investigation many cell types upstream downstream has been hindered due to lack specific driver lines. Here we describe a new collection over 800 split-LexA that cover approximately 300 types, including sugar sensory neurons, putative nociceptive ascending olfactory thermo-/hygro-sensory projection interneurons connected with MB-extrinsic various other types. We characterized activation phenotypes subset these lines identified neuron line most suitable reward substitution. Leveraging thousands confocal images associated collection, analyzed neuronal morphological stereotypy discovered one set output MBON08/MBON09, exhibits striking individuality asymmetry across animals. conjunction EM connectome maps, reported here offer powerful resource functional dissection circuits adult .
Language: Английский
Citations
0
Current Biology, Journal Year: 2025, Volume and Issue: 35(3), P. R110 - R124
Published: Feb. 1, 2025
Unlike any other group of animals, all ant species are social: individual ants share the food they gather with their nestmates and as a consequence must repeatedly leave nest to find then return home it. These back-and-forth foraging trips have been studied for about century much our growing understanding strategies underlying animal navigation has come from these studies. One important strategy that use keep track where on trip is 'path integration', in which continuously update 'home vector' gives estimated distance direction nest. As path integration accumulates errors, it cannot be relied bring precisely home: such precision accomplished by using views acquired before start foraging. Further learning scaffolded vectors or remembered vectors, guide route help useful experienced way. Many rely olfaction well vision guidance full details paths revealed how mix innate learnt multisensory cues. Wood ants, we focus this review, take an oscillating along pheromone trail sample odours, but acquire visual information only at peaks troughs oscillations. To provide working model neural basis multimodal navigational outline anatomy functioning major central brain areas circuits - complex, mushroom bodies lateral accessory lobes involved coordination behaviour olfactory patterns. Because brains not yet well-studied, work done notably, Drosophila, silkworm moths bees derive plausible circuitry can deliver ants' strategies.
Language: Английский
Citations
0
Current Research in Insect Science, Journal Year: 2025, Volume and Issue: unknown, P. 100113 - 100113
Published: May 1, 2025
Language: Английский
Citations
0
bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown
Published: Jan. 26, 2024
Abstract The relationship between sleep and memory is an active topic of investigation. In this context, we demonstrate that enhancing restores to flies with ablated Mushroom Bodies (MB), a key center; consistent across several assays. Mapping the underlying circuitry reveals circadian modulation subset Dopaminergic neurons (DANs) modulate aversive learning. Using imaging, show MB-ablation disrupts, time day these are most responsive. Knocking down receptor for clock output signal, Pigment-dispersing factor (Pdfr), in DANs MB-ablated flies. Crucially, does not result impairments absence functioning clock. Our results reveal neuromodulation’s role cognitive restoration, where aids damaged brains, but unexpectedly hinders process.
Language: Английский
Citations
3
Current Biology, Journal Year: 2022, Volume and Issue: 33(2), P. 215 - 227.e3
Published: Dec. 16, 2022
Language: Английский
Citations
12