Synaptic rearrangement of NMDA receptors controls memory engram formation and malleability in the cortex DOI Creative Commons
Benjamin Bessières, Julien P. Dupuis, Laurent Groc

et al.

Science Advances, Journal Year: 2024, Volume and Issue: 10(35)

Published: Aug. 30, 2024

Initially hippocampal dependent, memory representations rely on a broadly distributed cortical network as they mature over time. How these engrams acquire stability during systems-level consolidation without compromising their dynamic nature remains unclear. We identified highly responsive “consolidation switch” in the synaptic composition of N -methyl- d -aspartate receptors (NMDARs), which dictates progressive embedding and persistence enduring memories rat cortex. Cortical GluN2B subunit–containing NMDARs were preferentially recruited upon encoding associative olfactory to support neuronal allocation engrams. As proceeds, learning-induced redistribution outward synapses increased GluN2A subunit contribution enabled stabilization remote memories. In contrast, reincorporation subunits occurred subsequent forgetting. By manipulating surface distribution at synapses, we uncovered that rearrangement GluN2B-containing constitutes an essential tuning mechanism determines fate controls malleability.

Language: Английский

Representational drift: Emerging theories for continual learning and experimental future directions DOI
Laura N. Driscoll, Lea Duncker, Christopher D. Harvey

et al.

Current Opinion in Neurobiology, Journal Year: 2022, Volume and Issue: 76, P. 102609 - 102609

Published: Aug. 5, 2022

Language: Английский

Citations

96
Time and experience differentially affect distinct aspects of hippocampal representational drift DOI Creative Commons

Nitzan Geva,

Daniel Deitch,

Alon Rubin

et al.

Neuron, Journal Year: 2023, Volume and Issue: 111(15), P. 2357 - 2366.e5

Published: June 13, 2023

Language: Английский

Citations

69
Assessments of dentate gyrus function: discoveries and debates DOI
Mia Borzello, Steve Ramirez, Alessandro Treves

et al.

Nature reviews. Neuroscience, Journal Year: 2023, Volume and Issue: 24(8), P. 502 - 517

Published: June 14, 2023

Language: Английский

Citations

65
Dynamic and selective engrams emerge with memory consolidation DOI Creative Commons
Douglas Feitosa Tomé, Ying Zhang, Tomomi Aida

et al.

Nature Neuroscience, Journal Year: 2024, Volume and Issue: 27(3), P. 561 - 572

Published: Jan. 19, 2024

Episodic memories are encoded by experience-activated neuronal ensembles that remain necessary and sufficient for recall. However, the temporal evolution of memory engrams after initial encoding is unclear. In this study, we employed computational experimental approaches to examine how neural composition selectivity change with consolidation. Our spiking network model yielded testable predictions: transition from unselective selective as neurons drop out into engrams; inhibitory activity during recall essential selectivity; synaptic plasticity consolidation critical become selective. Using activity-dependent labeling, longitudinal calcium imaging a combination optogenetic chemogenetic manipulations in mouse dentate gyrus, conducted contextual fear conditioning experiments supported our model's predictions. results reveal dynamic changes engram mediated crucial emergence selectivity.

Language: Английский

Citations

22
The representation of context in mouse hippocampus is preserved despite neural drift DOI Creative Commons
Alexandra T. Keinath, Coralie‐Anne Mosser, Mark P. Brandon

et al.

Nature Communications, Journal Year: 2022, Volume and Issue: 13(1)

Published: May 3, 2022

The hippocampus is thought to mediate episodic memory through the instantiation and reinstatement of context-specific cognitive maps. However, recent longitudinal experiments have challenged this view, reporting that most hippocampal cells change their tuning properties over days even in same environment. Often referred as neural or representational drift, these dynamics raise questions about capacity content code. One such question whether how long-term impact code for context. To address this, we image large CA1 populations more than a month daily experience freely behaving mice participate an extended geometric morph paradigm. We find long-timescale changes population activity occur orthogonally representation context network space, allowing consistent readout contextual information across weeks. This population-level structure supported by heterogeneous patterns at level individual cells, where observe evidence positive relationship between interpretable coding stability. Together, results demonstrate spatial preserve relative representation.

Language: Английский

Citations

58
Emergence of a predictive model in the hippocampus DOI Creative Commons
Adam M. Miller,

Alex Jacob,

Adam I. Ramsaran

et al.

Neuron, Journal Year: 2023, Volume and Issue: 111(12), P. 1952 - 1965.e5

Published: April 3, 2023

Language: Английский

Citations

35
Coordinated drift of receptive fields in Hebbian/anti-Hebbian network models during noisy representation learning DOI
Shanshan Qin,

Shiva Farashahi,

David Lipshutz

et al.

Nature Neuroscience, Journal Year: 2023, Volume and Issue: 26(2), P. 339 - 349

Published: Jan. 12, 2023

Language: Английский

Citations

31
Cortical reactivations predict future sensory responses DOI
Nghia D. Nguyen, Andrew Lutas, Oren Amsalem

et al.

Nature, Journal Year: 2023, Volume and Issue: 625(7993), P. 110 - 118

Published: Dec. 13, 2023

Language: Английский

Citations

28
The respective activation and silencing of striatal direct and indirect pathway neurons support behavior encoding DOI Creative Commons
Christophe Varin, Amandine Cornil,

Delphine Houtteman

et al.

Nature Communications, Journal Year: 2023, Volume and Issue: 14(1)

Published: Aug. 17, 2023

The basal ganglia are known to control actions and modulate movements. Neuronal activity in the two efferent pathways of dorsal striatum is critical for appropriate behavioral control. Previous evidence has led divergent conclusions on respective engagement both during actions. Using calcium imaging evaluate how neurons direct indirect encode behaviors self-paced spontaneous explorations an open field, we observed that striatal exhibit distinct tuning properties. Supervised learning algorithms revealed pathway through their activation, whereas behavior-specific silencing. These properties remain stable weeks. Our findings highlight a complementary encoding with congruent activations multiple accessible given context, suppression competing behaviors. This model reconciles previous conflicting motor striatum.

Language: Английский

Citations

24
Critical Avalanches in Excitation-Inhibition Balanced Networks Reconcile Response Reliability with Sensitivity for Optimal Neural Representation DOI

Zhuda Yang,

Junhao Liang, Changsong Zhou

et al.

Physical Review Letters, Journal Year: 2025, Volume and Issue: 134(2)

Published: Jan. 15, 2025

Neural criticality has emerged as a unified framework that reconciles diverse multiscale neuronal dynamics such the irregular firing of individual neurons, sparse synchrony in populations, and emergence scale-free avalanches. However, functional role remains ambiguous. Here, we investigate neural representations response to external signals excitation-inhibition balanced networks. We reveal that, contrast with case for traditional critical branching model, state network simultaneously achieves maximal sensitivity, reliability, optimal representation due presence reliable avalanches induced by signals. further demonstrate heterogeneity inhibitory connections is mechanism underlying representation. Our study addresses longstanding challenge concerning significance criticality, namely intricate coexistence reliability sensitivity.

Language: Английский

Citations

1