Oxford University Press eBooks,
Journal Year:
2024,
Volume and Issue:
unknown, P. 431 - 496
Published: May 7, 2024
Abstract
‘Symptoms
and
syndromes
of
anxiety’
are
presented
here
as
reflecting
states
traits,
respectively.
These
reflect
outputs
from
sensitivities
specific
brain
areas
in
the
defensive
systems
described
Chapter
11.
The
chapter
discusses
anxiolytic,
panicolytic,
novel
psychedelic
drug
action
problems
treatment
resistance.
It
presents
a
‘double-hit’
hypothesis
trait
interactions
basis
for
disorder;
typology
neurally
based
disorders.
Importantly,
it
explains
why
symptoms
not
good
guide
syndromes,
comorbidity
is
norm
rather
than
an
exception,
how
cognition
memory
contribute
to
emotional
dysfunction.
concludes
with
some
suggestions
development
related
biomarkers
differential
diagnosis.
Oxford University Press eBooks,
Journal Year:
2024,
Volume and Issue:
unknown, P. 167 - 188
Published: May 7, 2024
Abstract
‘What
do
hippocampal
cell
fields
represent?’
argues
against
the
conventional
idea
of
‘place’
fields.
Clear
eyeblink,
time,
displace,
and
other
‘fields’
argue
place
per
se;
as
failures
most
obvious
to
map
space
either
externally
or
in
brain;
with
‘remapping’
being
inconsistent
any
truly
spatial
metric.
As
visual
firing
is
not
a
good
guide
information
coded.
Hippocampal
easily
understood
receipt
efference
copies
from
distributed
assemblies
that
code
available
goals;
dorsal
ventral
cells
largely
echoing
cortical
trends
‘where’
‘what’
goal,
respectively.
Head
direction
cells,
path
integration,
topographic
mapping
hippocampus
are
also
discussed.
Oxford University Press eBooks,
Journal Year:
2024,
Volume and Issue:
unknown, P. 1 - 46
Published: May 7, 2024
Abstract
This
chapter
provides
an
overview
of
the
need
for
a
neuropsychology
anxiety,
distinction
between
anxiety
and
fear,
definition
‘anxiety’
via
actions
selective
anxiolytic
drugs,
septo-hippocampal
system
(SHS)
as
central
to
control
goal
inhibition
that
underlies
adaptive
pathological
anxiety.
A
key
hippocampal
operation
is
motivated
suppression
goals
can,
in
excess,
deliver
disorder
and,
when
weak,
catastrophic
hypermnesia.
Attraction,
repulsion,
conflict
are
controlled
by
interlinked
hierarchical
systems,
sensitivity
which
personality
traits
that,
extreme,
result
psychiatric
disorder.
The
these
systems
solution
current
problems
with
diagnosis,
reinforcement
theory
(RST)
personality,
understanding
treatment
sensitivity,
resistance,
comorbidity
disorders.
Oxford University Press eBooks,
Journal Year:
2024,
Volume and Issue:
unknown, P. 327 - 370
Published: May 7, 2024
Abstract
‘The
neurology
of
anxiety—planning
circuits’
extends
the
anxiolytic-derived
neuropsychology
survival
circuits
(including
hippocampus
and
anterior
cingulate
cortex)
to
goal
planning
prefrontal
cortex.
It
first
discusses
results
from
issues
with
early
work
using
lesions
as
treatments
neurotic
disorders
considers
evolution
frontal
cortex
in
context
defence
hierarchy
emphasizing
fact
that
‘deeper’
areas
are
phylogenetically
more
ancient.
then
details
anatomy
cortex,
importance
active
memory
dorsal
ventral
trend
perception-action
cycles,
control
conflict.
also
describes
a
‘mesial’
linked
internal
insula
source
monitoring
arousal/attention
outputs
Goal
Inhibition
System
(GIS).
The
final
sections
integrate
these
data
into
new,
extended,
2D
theory
systems.
Oxford University Press eBooks,
Journal Year:
2024,
Volume and Issue:
unknown, P. 285 - 326
Published: May 7, 2024
Abstract
‘A
theory
of
the
septo-hippocampal
system’
adds
a
series
assumptions
to
range
data
principles
we
derived
from
our
overview
system
(SHS)
data.
It
outlines
problems
with
existing
‘single
process’
perspectives:
consolidation,
voluntary
movement,
habituation,
spatial
mapping.
also
argues
against
multiple
functions
as
being
ad
hoc.
then
key
basic
operations
SHS
goal-conflict
detector
and
consequent
processes
familiarity
recognition,
trouble
shooting,
‘just
checking’,
fault
tagging.
explains
how
these
complex
results
are
produced
iteratively
by
simple
mechanisms
discusses
internal
processing,
gating
required.
The
circuits
gates
applied
four
scenarios:
novelty,
just
checking,
conflict,
disengagement.
emphasizes
that
way
subject
solves
may
not
be
intended
experimenter
needs
determined.
Finally,
it
rhythmical
slow
activity/theta
rhythmicity
acts
synchronize
iterative
processing
across
target
structures.
Oxford University Press eBooks,
Journal Year:
2024,
Volume and Issue:
unknown, P. 431 - 496
Published: May 7, 2024
Abstract
‘Symptoms
and
syndromes
of
anxiety’
are
presented
here
as
reflecting
states
traits,
respectively.
These
reflect
outputs
from
sensitivities
specific
brain
areas
in
the
defensive
systems
described
Chapter
11.
The
chapter
discusses
anxiolytic,
panicolytic,
novel
psychedelic
drug
action
problems
treatment
resistance.
It
presents
a
‘double-hit’
hypothesis
trait
interactions
basis
for
disorder;
typology
neurally
based
disorders.
Importantly,
it
explains
why
symptoms
not
good
guide
syndromes,
comorbidity
is
norm
rather
than
an
exception,
how
cognition
memory
contribute
to
emotional
dysfunction.
concludes
with
some
suggestions
development
related
biomarkers
differential
diagnosis.
