Neuron, Journal Year: 2025, Volume and Issue: 113(1), P. 154 - 183
Published: Jan. 1, 2025
Language: Английский
Journal of Neurophysiology, Journal Year: 2024, Volume and Issue: 131(3), P. 529 - 540
Published: Feb. 7, 2024
Neuropsychiatric illness may be associated with altered excitation/inhibition balance. A single electroencephalogram (EEG) parameter, the aperiodic exponent of power spectra, predict ratio between excitation and inhibition. Here, we use cortical EEGs in mice to evaluate this hypothesis, using pharmacological manipulations known mechanism. We show that EEG spectra is not a reliable marker ratio. Thus, alternative markers must sought.
Language: Английский
Citations
21
Journal of Neuroscience, Journal Year: 2024, Volume and Issue: 44(13), P. e1332232024 - e1332232024
Published: Feb. 19, 2024
Measures of intrinsic brain function at rest show promise as predictors cognitive decline in humans, including EEG metrics such individual α peak frequency (IAPF) and the aperiodic exponent, reflecting strongest oscillations relative balance excitatory/inhibitory neural activity, respectively. Both IAPF exponent decrease with age have been associated worse executive working memory. However, few studies jointly examined their associations function, none association longitudinal rather than cross-sectional impairment. In a preregistered secondary analysis data from Midlife United States (MIDUS) study, we tested whether measured predict (
Language: Английский
Citations
18
eNeuro, Journal Year: 2025, Volume and Issue: unknown, P. ENEURO.0064 - 24.2024
Published: Jan. 8, 2025
The brain attends to environmental rhythms by aligning the phase of internal oscillations. However, factors underlying fluctuations in strength this entrainment remain largely unknown. In present study we examined whether low-frequency EEG rhythmic stimulus sequences varied with pupil size and posterior alpha-band power, thought reflect arousal level excitability cortical areas, respectively. We recorded scalp while participants carried out an intermodal selective attention task, which they were instructed attend a sequence visual or auditory stimuli ignore other perceptual modality. As expected, intertrial coherence (ITC), measure strength, was larger for task-relevant than task-irrelevant Across experiment, alpha power strongly linked each other. Interestingly, ITC tracked both variables: associated increase sequence, whereas decrease sequences. Exploratory analyses showed that temporal relation between emerged time periods around maxima minima. These results indicate endogenous sources contribute distinctly entrainment. Significance statement Fluctuations state powerfully shape perception external stimuli. Understanding physiological signatures is crucial understand how selectively switches content. Here studied two attentional state, pupil-linked band, activity Our reveal common dissociable influences these at slow scales. Furthermore, measuring including as covariates statistical models can help studies focusing on provides new evidence direct influence
Language: Английский
Citations
2
Developmental Psychobiology, Journal Year: 2022, Volume and Issue: 64(3)
Published: Feb. 28, 2022
The aperiodic exponent of the electroencephalogram (EEG) power spectrum has received growing attention as a physiological marker neurodevelopmental psychopathology, including attention-deficit/hyperactivity disorder (ADHD). However, its use ADHD risk across development, and particularly in very young children, is limited by unknown reliability, difficulty aligning canonical band-based measures development periods, unclear effects treatment later development. Here, we investigate internal consistency EEG slope association with both infants (n = 69, 1-month-old) adolescents 262, ages 11-17 years). Results confirm good to excellent infancy adolescence. In infancy, larger was associated greater family history ADHD. contrast, adolescence, diagnosis smaller exponent, but only children who had not stimulant medication treatment. suggest that disruptions cortical may be detectable shortly after birth via this approach. Together, findings imply dynamic developmental shift which developmentally normative flattening exaggerated ADHD, potentially reflecting imbalances excitation inhibition could contribute long-lasting differences brain connectivity.
Language: Английский
Citations
61
eLife, Journal Year: 2022, Volume and Issue: 11
Published: Sept. 8, 2022
Macroscopic neural dynamics comprise both aperiodic and periodic signal components. Recent advances in parameterizing power spectra offer practical tools for evaluating these features separately. Although signals vary dynamically express non-stationarity relation to ongoing behaviour perception, current methods yield static spectral decompositions. Here, we introduce Spectral Parameterization Resolved Time (SPRiNT) as a novel method decomposing complex into elements time-resolved manner. First, demonstrate, with naturalistic synthetic data, SPRiNT's capacity reliably recover time-varying features. We emphasize specific strengths compared other time-frequency parameterization approaches based on wavelets. Second, use SPRiNT illustrate how fluctuate across time empirical resting-state EEG data (n=178) relate the observed changes parameters over participants' demographics behaviour. Lastly, demonstrate movement intracranial recordings rodents. foresee responding growing neuroscientific interests of advancing quantitation at natural scales
Language: Английский
Citations
59
Building and Environment, Journal Year: 2022, Volume and Issue: 225, P. 109619 - 109619
Published: Sept. 21, 2022
Language: Английский
Citations
41
Scientific Reports, Journal Year: 2023, Volume and Issue: 13(1)
Published: May 7, 2023
An early disruption of neuronal excitation-inhibition (E-I) balance in preclinical animal models Alzheimer's disease (AD) has been frequently reported, but is difficult to measure directly and non-invasively humans. Here, we examined known novel neurophysiological measures sensitive E-I patients across the AD continuum. Resting-state magnetoencephalography (MEG) data 86 amyloid-biomarker-confirmed subjects continuum (17 diagnosed with subjective cognitive decline, 18 mild impairment (MCI) 51 dementia due probable (AD dementia)), 46 healthy elderly 20 young control were reconstructed source-space. was investigated by detrended fluctuation analysis (DFA), a functional E/I (fE/I) algorithm, aperiodic exponent power spectrum. We found disrupted ratio specifically, lower DFA, shift towards higher excitation, fE/I exponent. Healthy showed ratios (< 1.0) than reported previous literature, not explained age or choice an arbitrary threshold parameter, which warrants caution interpretation results. Correlation analyses that DFA (E-I imbalance) (more excitation) associated worse score patients. In contrast, hippocampi MCI score. This MEG-study imbalance, likely increased dementia, stage To accurately determine direction balance, validations currently used markers additional vivo are required.
Language: Английский
Citations
36
Journal of Neurology, Journal Year: 2023, Volume and Issue: 270(8), P. 3958 - 3969
Published: May 3, 2023
Language: Английский
Citations
34
Biomedicines, Journal Year: 2023, Volume and Issue: 11(6), P. 1607 - 1607
Published: June 1, 2023
Developmental Dyslexia (DD) is a neurobiological condition affecting the ability to read fluently and/or accurately. Analyzing resting-state electroencephalographic (EEG) activity in DD may provide deeper characterization of underlying pathophysiology and possible biomarkers. So far, studies investigating provided limited evidence did not consider aperiodic component power spectrum. In present study, adults with (n = 26) without 31) underwent reading skills assessment EEG investigate potential alterations activity, their impact on periodic counterpart performance. parieto-occipital channels, participants showed significantly different as indexed by flatter lower These measures were related text time, suggesting link individual differences difficulties. beta band, group decreased aperiodic-adjusted compared typical readers, which was correlated word accuracy. Overall, here we showing endogenous consistently increased neural noise hypothesis. addition, confirm rhythms, are discussed terms magnocellular-dorsal stream deficit.
Language: Английский
Citations
25
Cerebral Cortex, Journal Year: 2023, Volume and Issue: 33(12), P. 7941 - 7951
Published: March 16, 2023
Abstract Higher-level cognitive functions are mediated via complex oscillatory activity patterns and its analysis is dominating neuroscience research. However, besides (period) activity, also aperiodic constitutes neural dynamics, but relevance for higher-level only beginning to be understood. The present study examined whether the broadband EEG reflects principles of metacontrol. Metacontrol conceptualizes it more useful engage in flexible processing incoming information or shield processes from (persistence-heavy processing). We behavioral data a sample n = 191 healthy participants performing Simon Go/NoGo task that can assumed induce different metacontrol states (persistence-biased vs. flexibility-biased). Aperiodic was estimated using FOOOF toolbox power spectrum. There higher exponent offset NoGo trials compared with Go trials, incongruent (Go) congruent trials. Thus, increases during persistence-heavy processing, decreases flexibility-heavy processing. These findings link features signal concepts describing dynamics how control modes applied. Therefore, substantially extends importance understanding functions.
Language: Английский
Citations
24