Flexible gating between subspaces in a neural network model of internally guided task switching DOI Creative Commons
Yue Liu, Xiao‐Jing Wang

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: Aug. 1, 2024

Behavioral flexibility relies on the brain's ability to switch rapidly between multiple tasks, even when task rule is not explicitly cued but must be inferred through trial and error. The underlying neural circuit mechanism remains poorly understood. We investigated recurrent networks (RNNs) trained perform an analog of classic Wisconsin Card Sorting Test. consist two modules responsible for representation sensorimotor mapping, respectively, where each module comprised a with excitatory neurons three major types inhibitory neurons. found that by self-sustained persistent activity across trials, error monitoring gated mapping emerged from training. Systematic dissection RNNs revealed detailed consistent different hyperparameters. networks' dynamical trajectories rules resided in separate subspaces population activity; collapsed performance was reduced chance level dendrite-targeting somatostatin-expressing interneurons were silenced, illustrating how phenomenological description representational explained specific mechanism. flexible switching unclear. Here authors analyzed modular network models cell reveal uncued switching.

Language: Английский

Dynamical consequences of regional heterogeneity in the brain’s transcriptional landscape DOI Creative Commons
Gustavo Deco, Morten L. Kringelbach, Aurina Arnatkevičiūtė

et al.

Science Advances, Journal Year: 2021, Volume and Issue: 7(29)

Published: July 14, 2021

Regional heterogeneity in the brain’s transcriptional landscape supports complex neuronal dynamics.

Language: Английский

Citations

128
Mechanisms of distributed working memory in a large-scale network of macaque neocortex DOI Creative Commons
Jorge F. Mejías, Xiao‐Jing Wang

eLife, Journal Year: 2022, Volume and Issue: 11

Published: Feb. 24, 2022

Neural activity underlying working memory is not a local phenomenon but distributed across multiple brain regions. To elucidate the circuit mechanism of such activity, we developed an anatomically constrained computational model large-scale macaque cortex. We found that mnemonic internal states may emerge from inter-areal reverberation, even in regime where none isolated areas capable generating self-sustained activity. The pattern along cortical hierarchy indicates transition space, separating engaged and those which do not. A host spatially distinct attractor found, potentially subserving various processes. yields testable predictions, including idea counterstream inhibitory bias, role prefrontal controlling attractors, resilience to lesions or inactivation. This work provides theoretical framework for identifying mechanisms principles cognitive

Language: Английский

Citations

105
An adversarial collaboration protocol for testing contrasting predictions of global neuronal workspace and integrated information theory DOI Creative Commons
Lucía Melloni, Liad Mudrik, Michael Pitts

et al.

PLoS ONE, Journal Year: 2023, Volume and Issue: 18(2), P. e0268577 - e0268577

Published: Feb. 10, 2023

The relationship between conscious experience and brain activity has intrigued scientists philosophers for centuries. In the last decades, several theories have suggested different accounts these relationships. These developed in parallel, with little to no cross-talk among them. To advance research on consciousness, we established an adversarial collaboration proponents of two major field, Global Neuronal Workspace Integrated Information Theory. Together, devised preregistered experiments that test contrasting predictions concerning location timing correlates visual which been endorsed by theories’ proponents. Predicted outcomes should either support, refute, or challenge theories. Six theory-impartial laboratories will follow study protocol specified here, using three complementary methods: Functional Magnetic Resonance Imaging (fMRI), Magneto-Electroencephalography (M-EEG), intracranial electroencephalography (iEEG). include built-in replications, both labs within datasets. Through this ambitious undertaking, hope provide decisive evidence favor against clarify footprints perception human brain, while also providing innovative model large-scale, collaborative, open science practice.

Language: Английский

Citations

69
Gradients of neurotransmitter receptor expression in the macaque cortex DOI Creative Commons
Seán Froudist‐Walsh, Ting Xu, Meiqi Niu

et al.

Nature Neuroscience, Journal Year: 2023, Volume and Issue: 26(7), P. 1281 - 1294

Published: June 19, 2023

Abstract Dynamics and functions of neural circuits depend on interactions mediated by receptors. Therefore, a comprehensive map receptor organization across cortical regions is needed. In this study, we used in vitro autoradiography to measure the density 14 neurotransmitter types 109 areas macaque cortex. We integrated data with anatomical, genetic functional connectivity into common space. uncovered principal gradient expression per neuron. This aligns hierarchy from sensory cortex higher cognitive areas. A second gradient, driven serotonin 5-HT 1A receptors, peaks anterior cingulate, default mode salience networks. found similar pattern human brain. Thus, may be promising translational model serotonergic processing disorders. The gradients enable rapid, reliable information slow, flexible integration

Language: Английский

Citations

59
Stochastic resonance in the small-world networks with higher order neural motifs interactions DOI
Tianyu Li, Dong Yu, Yong Wu

et al.

The European Physical Journal Special Topics, Journal Year: 2024, Volume and Issue: 233(4), P. 797 - 806

Published: March 8, 2024

Language: Английский

Citations

20
A disinhibitory circuit mechanism explains a general principle of peak performance during mid-level arousal DOI Creative Commons
Lola Beerendonk, Jorge F. Mejías, Stijn A. Nuiten

et al.

Proceedings of the National Academy of Sciences, Journal Year: 2024, Volume and Issue: 121(5)

Published: Jan. 26, 2024

Perceptual decision-making is highly dependent on the momentary arousal state of brain, which fluctuates over time a scale hours, minutes, and even seconds. The textbook relationship between task performance captured by an inverted U-shape, as put forward in Yerkes–Dodson law. This law suggests optimal at moderate levels impaired low or high levels. However, despite its popularity, evidence for this humans mixed best. Here, we use pupil-indexed data from various perceptual tasks to provide converging U-shaped spontaneous fluctuations across different decision types (discrimination, detection) sensory modalities (visual, auditory). To further understand relationship, built neurobiologically plausible mechanistic model show that it possible reproduce our findings incorporating two interneurons are both modulated signal. architecture produces dynamical regimes under influence arousal: one regime increases with another decreases arousal, together forming arousal–performance relationship. We conclude general robust property processing. It might be brought about act disinhibitory pathway neural populations encode available used decision.

Language: Английский

Citations

19
Data-driven multiscale computational models of cortical and subcortical regions DOI
Srikanth Ramaswamy

Current Opinion in Neurobiology, Journal Year: 2024, Volume and Issue: 85, P. 102842 - 102842

Published: Feb. 5, 2024

Language: Английский

Citations

16
A dopamine gradient controls access to distributed working memory in the large-scale monkey cortex DOI Creative Commons
Seán Froudist‐Walsh,

Daniel P. Bliss,

Xingyu Ding

et al.

Neuron, Journal Year: 2021, Volume and Issue: 109(21), P. 3500 - 3520.e13

Published: Sept. 17, 2021

Dopamine is required for working memory, but how it modulates the large-scale cortex unknown. Here, we report that dopamine receptor density per neuron, measured by autoradiography, displays a macroscopic gradient along macaque cortical hierarchy. This incorporated in connectome-based model endowed with multiple neuron types. The captures an inverted U-shaped dependence of memory on and spatial patterns persistent activity observed over 90 experimental studies. Moreover, show crucial filtering out irrelevant stimuli enhancing inhibition from dendrite-targeting interneurons. Our revealed activity-silent trace can be realized facilitation inter-areal connections adjusting induces switch this internal state to distributed activity. work represents cross-level understanding molecules cell types recurrent circuit dynamics underlying core cognitive function across primate cortex.

Language: Английский

Citations

87
Characterizing Cortex-Wide Dynamics with Wide-Field Calcium Imaging DOI Creative Commons
Chi Ren, Takaki Komiyama

Journal of Neuroscience, Journal Year: 2021, Volume and Issue: 41(19), P. 4160 - 4168

Published: April 23, 2021

The brain functions through coordinated activity among distributed regions. Wide-field calcium imaging, combined with improved genetically encoded indicators, allows sufficient signal-to-noise ratio and spatiotemporal resolution to afford a unique opportunity capture cortex-wide dynamics on moment-by-moment basis in behaving animals. Recent applications of this approach have been uncovering cortical at unprecedented scales during various cognitive processes, ranging from relatively simple sensorimotor integration more complex decision-making tasks. In review, we will highlight recent scientific advances enabled by wide-field imaging mice. We then summarize several technical considerations future opportunities for uncover large-scale circuit dynamics.

Language: Английский

Citations

85
50 years of mnemonic persistent activity: quo vadis? DOI Creative Commons
Xiao‐Jing Wang

Trends in Neurosciences, Journal Year: 2021, Volume and Issue: 44(11), P. 888 - 902

Published: Oct. 13, 2021

Language: Английский

Citations

77