Flexible multitask computation in recurrent networks utilizes shared dynamical motifs

Nature Neuroscience, Journal Year: 2024, Volume and Issue: 27(7), P. 1349 - 1363

Published: July 1, 2024

Abstract Flexible computation is a hallmark of intelligent behavior. However, little known about how neural networks contextually reconfigure for different computations. In the present work, we identified an algorithmic substrate modular through study multitasking artificial recurrent networks. Dynamical systems analyses revealed learned computational strategies mirroring subtask structure training task set. motifs, which are recurring patterns activity that implement specific computations dynamics, such as attractors, decision boundaries and rotations, were reused across tasks. For example, tasks requiring memory continuous circular variable repurposed same ring attractor. We showed dynamical motifs implemented by clusters units when unit activation function was restricted to be positive. Cluster lesions caused performance deficits. Motifs reconfigured fast transfer learning after initial phase learning. This work establishes fundamental compositional computation, intermediate between neuron network. As whole-brain studies simultaneously record from multiple specialized systems, motif framework will guide questions specialization generalization.

Language: Английский

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Thyroid hormone remodels cortex to coordinate body-wide metabolism and exploration

Cell, Journal Year: 2024, Volume and Issue: 187(20), P. 5679 - 5697.e23

Published: Aug. 22, 2024

Animals adapt to environmental conditions by modifying the function of their internal organs, including brain. To be adaptive, alterations in behavior must coordinated with functional state organs throughout body. Here, we find that thyroid hormone-a regulator metabolism many peripheral organs-directly activates cell-type-specific transcriptional programs frontal cortex adult male mice. These are enriched for axon-guidance genes glutamatergic projection neurons, synaptic regulatory both astrocytes and pro-myelination factors oligodendrocytes, suggesting widespread plasticity cortical circuits. Indeed, whole-cell electrophysiology revealed hormone alters excitatory inhibitory transmission, an effect requires hormone-induced gene presynaptic neurons. Furthermore, action regulates innate exploratory behaviors causally promotes decision-making. Thus, acts directly on cerebral males coordinate whole-body metabolic state.

Language: Английский

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Shared and specialized coding across posterior cortical areas for dynamic navigation decisions

Neuron, Journal Year: 2022, Volume and Issue: 110(15), P. 2484 - 2502.e16

Published: June 8, 2022

Animals adaptively integrate sensation, planning, and action to navigate toward goal locations in ever-changing environments, but the functional organization of cortex supporting these processes remains unclear. We characterized encoding approximately 90,000 neurons across mouse posterior during a virtual navigation task with rule switching. The behavioral variables was highly distributed cortical areas differed magnitude, resulting three spatial gradients for visual cue, position plus dynamics choice formation, locomotion, peaks respectively visual, retrosplenial, parietal cortices. Surprisingly, conjunctive single similar throughout cortex, creating high-dimensional representations all instead revealing computations specialized each area. propose that, guiding decisions, operates parallel rather than hierarchically, collectively generates state representation behavior environment, area handling distinct information modalities.

Language: Английский

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Cognitive experience alters cortical involvement in goal-directed navigation

eLife, Journal Year: 2022, Volume and Issue: 11

Published: June 23, 2022

Neural activity in the mammalian cortex has been studied extensively during decision tasks, and recent work aims to identify under what conditions is actually necessary for these tasks. We discovered that mice with distinct cognitive experiences, beyond sensory motor learning, use different cortical areas neural patterns solve same navigation task, revealing past learning as a critical determinant of whether goal-directed navigation. used optogenetics calcium imaging study necessity multiple training histories. Posterior parietal retrosplenial were mostly dispensable accurate performance simple task. In contrast, essential task when previously trained on complex tasks delay periods or association switches. Multiarea showed that, complex-task experience, single-neuron had higher selectivity neuron–neuron correlations weaker, leading codes information. Therefore, experience key factor determining have causal role

Language: Английский

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How ‘visual’ is the visual cortex? The interactions between the visual cortex and other sensory, motivational and motor systems as enabling factors for visual perception

Philosophical Transactions of the Royal Society B Biological Sciences, Journal Year: 2023, Volume and Issue: 378(1886)

Published: Aug. 7, 2023

The definition of the visual cortex is primarily based on evidence that lesions this area impair perception. However, does not exclude may process more information than retinal origin alone, or other brain structures contribute to vision. Indeed, research across past decades has shown non-visual information, such as neural activity related reward expectation and value, locomotion, working memory sensory modalities, can modulate primary cortical responses inputs. Nevertheless, function poorly understood. Here we review recent evidence, coming from studies in rodents, arguing motor effects play a role processing itself, for instance disentangling direct auditory sound-evoked orofacial movement. These findings are placed broader framework casting vision terms predictive under control frontal, reward- motor-related systems. In contrast prevalent notion exclusively constructed by system, propose percepts generated larger network-the extended system-spanning cortices, supramodal areas frontal This article part theme issue 'Decision processes multisensory perception'.

Language: Английский

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Prefrontal Cortex Encodes Behavior States Decoupled from Movement

Published: Jan. 1, 2025

Language: Английский

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Compositional pretraining improves computational efficiency and matches animal behaviour on complex tasks

Nature Machine Intelligence, Journal Year: 2025, Volume and Issue: unknown

Published: May 19, 2025

Language: Английский

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Single neuron responses to perceptual difficulty in the mouse auditory cortex

Science Advances, Journal Year: 2024, Volume and Issue: 10(33)

Published: Aug. 14, 2024

Perceptual learning leads to improvement in behavioral performance, yet how the brain supports challenging perceptual demands is unknown. We used two photon imaging mouse primary auditory cortex during behavior a Go-NoGo task designed test difficulty. Using general linear model analysis, we found subset of neurons that increased their responses high demands. Single both Go and NoGo sounds when mice were engaged more difficult discrimination. This responsiveness contributes enhanced cortical network discriminability for learned sounds. Under passive listening conditions, same responded weaker similar sound pairs task, training protocol by itself induced specific suppression Our findings identify neuronal activity modulated demands, which fundamental feature associated with improvement.

Language: Английский

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The role of motor cortex in motor sequence execution depends on demands for flexibility

Nature Neuroscience, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 4, 2024

Language: Английский

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Functional (ir)Relevance of Posterior Parietal Cortex during Audiovisual Change Detection

Journal of Neuroscience, Journal Year: 2022, Volume and Issue: 42(26), P. 5229 - 5245

Published: May 31, 2022

The posterior parietal cortex (PPC) plays a key role in integrating sensory inputs from different modalities to support adaptive behavior. Neuronal activity PPC reflects perceptual decision-making across behavioral tasks, but the mechanistic involvement of is unclear. In an audiovisual change detection task, we tested hypothesis that required arbitrate between noisy two and help decide which modality occurred. trained male mice, found extensive single-neuron population-level encoding task-relevant visual auditory stimuli, trial history, as well upcoming responses. However, despite these rich neural correlates, would theoretically be sufficient solve optogenetic inactivation did not affect or performance. Thus, correlates faithfully tracking variables predicting responses, was relevant for detection. This functional dissociation questions sensory- task-related associative circuits during Furthermore, our results highlight necessity dissociate when exploring basis perception SIGNIFICANCE STATEMENT active many daily capturing its function has remained challenging. Specifically, it proposed integration hub multisensory inputs. Here, that, rather than classical cue integration, mouse involved segregation discrimination modalities. Surprisingly, although tracked current past stimuli reflected ongoing process, task show apparent redundancy PPC. These narrow down circuits, direct search those dynamics causally drive decision-making.

Language: Английский

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