Release of cognitive and multimodal MRI data including real-world tasks and hippocampal subfield segmentations DOI Creative Commons
Ian A. Clark, Eleanor A. Maguire

Scientific Data, Journal Year: 2023, Volume and Issue: 10(1)

Published: Aug. 16, 2023

We share data from N = 217 healthy adults (mean age 29 years, range 20-41; 109 females, 108 males) who underwent extensive cognitive assessment and neuroimaging to examine the neural basis of individual differences, with a particular focus on brain structure called hippocampus. Cognitive were collected using wide array questionnaires, naturalistic tests that examined imagination, autobiographical memory recall spatial navigation, traditional laboratory-based such as recalling word pairs, comprehensive characterisation strategies used perform tests. 3 Tesla MRI also acquired include multi-parameter mapping tissue microstructure, diffusion-weighted MRI, T2-weighted high-resolution partial volume structural scans (with masks hippocampal subfields manually segmented these scans), whole resting state functional high resolution scans. This rich dataset will be value clinical neuroscientists researching real-world cognition, brain-behaviour associations, more. All are freely available Dryad.

Language: Английский

Functional segregation of rostral and caudal hippocampus in associative memory DOI Creative Commons
Alicia Nunez Vorobiova, Matteo Feurra, Enea Francesco Pavone

et al.

Frontiers in Human Neuroscience, Journal Year: 2025, Volume and Issue: 19

Published: Feb. 10, 2025

Introduction The hippocampus plays a crucial role in episodic memory. Given its complexity, the participates multiple aspects of higher cognitive functions, among which are semantics-based encoding and retrieval. However, “where,” “when” “how” distinct memory processing still under debate. Methods Here, we employed visual associative task that involved three levels subjective congruence to delineate differential involvement rostral caudal portions (also referred as anterior/posterior portions) human during encoding, recognition recall. Results Through stereo-EEG recordings epilepsy patients show is reflected by hippocampal activity In contrast, selectively activates hippocampus. temporal dynamics manifested gamma power increase, partially overlaps with low-frequency decrease Congruence modulate prominently Discussion These findings highlight an anatomical segregation accordance contributions partitions

Language: Английский

Citations

0
Two long-axis dimensions of hippocampal-cortical integration support memory function across the adult lifespan DOI Open Access
Kristin Nordin, Robin Pedersen, Farshad Falahati

et al.

Published: Feb. 13, 2025

The hippocampus is a complex structure critically involved in numerous behavior-regulating systems. In young adults, multiple overlapping spatial modes along its longitudinal and transverse axes describe the organization of functional integration with neocortex, extending traditional framework emphasizing differences between sharply segregated hippocampal subregions. Yet, it remains unknown whether these (i.e., gradients) persist across adult human lifespan, relate to memory molecular markers associated brain function cognition. two independent samples, we demonstrate that principal anteroposterior second-order, mid-to-anterior/posterior neocortical connectivity, representing distinct dimensions macroscale cortical organization, manifest lifespan. Specifically, individual topography second-order gradient predicted episodic mirrored dopamine D1 receptor distribution, capturing shared organization. Older age was less transitions gradients increased homogeneity). Importantly, youth-like profile preserved – age-related dedifferentiation as marker cognitive decline. Our results underscore critical role mapping multidimensional understanding neural circuits support

Language: Английский

Citations

0
Hippocampal Subfield Vulnerability and Functional Connectivity in Cognitive Decline: a Comparison Between Parkinson’s Disease and Mild Cognitive Impairmente DOI
Na Wang, Chunxiao Xu, Xueling Liu

et al.

Clinical Neuroradiology, Journal Year: 2025, Volume and Issue: unknown

Published: May 5, 2025

Language: Английский

Citations

0
Single voxel autocorrelation uncovers gradients of temporal dynamics in the hippocampus and entorhinal cortex during rest and navigation DOI
Nichole R. Bouffard, Ali Golestani, Iva K. Brunec

et al.

Cerebral Cortex, Journal Year: 2022, Volume and Issue: 33(6), P. 3265 - 3283

Published: Dec. 27, 2022

Abstract During navigation, information at multiple scales needs to be integrated. Single-unit recordings in rodents suggest that gradients of temporal dynamics the hippocampus and entorhinal cortex support this integration. In humans, representation are observed, such granularity represented increases along long axis hippocampus. The neural underpinnings gradient however, still unknown. Current research is limited by coarse fMRI analysis techniques obscure activity individual voxels, preventing investigation how moment-to-moment changes brain signal organized they related behavior. Here, we measured stability single voxels over time uncover previously unappreciated cortex. Using our novel, voxel autocorrelation technique, show a medial-lateral hippocampal gradient, as well continuous anterolateral-posteromedial extent. Importantly, anterior-medial was modulated navigational difficulty, providing first evidence relevant for This work opens door future on within these structures integration goal-directed

Language: Английский

Citations

12
Three‐dimensional histology reveals dissociable human hippocampal long‐axis gradients of Alzheimer's pathology DOI Creative Commons
Diana Ortega‐Cruz,

Kimberly S. Bress,

Harshvardhan Gazula

et al.

Alzheimer s & Dementia, Journal Year: 2024, Volume and Issue: 20(4), P. 2606 - 2619

Published: Feb. 18, 2024

Abstract INTRODUCTION Three‐dimensional (3D) histology analyses are essential to overcome sampling variability and understand pathological differences beyond the dissection axis. We present Path2MR, first pipeline allowing 3D reconstruction of sparse human without a magnetic resonance imaging (MRI) reference. implemented Path2MR with post‐mortem hippocampal sections explore pathology gradients in Alzheimer's disease. METHODS Blockface photographs brain hemisphere slices used for reconstruction, from which an MRI‐like image is generated using machine learning. Histology aligned reconstructed subsequently atlas standard space. RESULTS successfully registered histological their anatomic position along longitudinal Combined histopathology quantification, we found expected peak tau at anterior end hippocampus, whereas amyloid‐beta (Aβ) displayed quadratic anterior‐posterior distribution. CONCLUSION enables any bank data set, revealed significant hippocampus between Aβ. Highlights three‐dimensional blockface photographs. This does not require dense specimen or subject‐specific (MR) image. Anatomically consistent mapping was obtained Path2MR. Our gradient pathology. In contrast, deposition closer body.

Language: Английский

Citations

2
Specialization of anterior and posterior hippocampal functional connectivity differs in autism DOI Creative Commons
J. Kember,

P. Patenaude,

Hilary Sweatman

et al.

Autism Research, Journal Year: 2024, Volume and Issue: 17(6), P. 1126 - 1139

Published: May 21, 2024

Abstract Structural and functional differences in the hippocampus have been related to episodic memory social impairments observed autism spectrum disorder (ASD). In neurotypical individuals, hippocampal–cortical connectivity systematically varies between anterior posterior hippocampus, with changes during typical development. It remains unknown whether this specialization of anterior–posterior hippocampal is disrupted ASD, age‐related exist ASD. We examined an ASD ( N = 139) non‐autistic comparison group 133) aged 5–21 using resting‐state magnetic resonance imaging (MRI) data from Healthy Brain Network (HBN). Consistent previous results, we lower whole medial prefrontal cortex Moreover, preferential relative for memory‐sensitive regions parietal was reduced demonstrating a weaker connectivity. Finally, precuneus negatively correlated age but remained stable group, suggesting altered developmental specialization. Together, these may help us understand neurobiological basis found

Language: Английский

Citations

2
Reconstructing Spatio-Temporal Trajectories of Visual Object Memories in the Human Brain DOI Creative Commons
Julia Lifanov, Benjamin Griffiths, Juan Linde‐Domingo

et al.

eNeuro, Journal Year: 2024, Volume and Issue: 11(9), P. ENEURO.0091 - 24.2024

Published: Sept. 1, 2024

How the human brain reconstructs, step-by-step, core elements of past experiences is still unclear. Here, we map spatiotemporal trajectories along which visual object memories are reconstructed during associative recall. Specifically, inquire whether retrieval reinstates feature representations in a copy-like but reversed direction with respect to initial perceptual experience, or alternatively, this reconstruction involves format transformations and regions beyond perception. Participants from two cohorts studied new associations between verbs randomly paired images, subsequently recalled objects when presented corresponding verb cue. We first analyze multivariate fMRI patterns where high- low-level features can be decoded perception retrieval, showing that dominated by conceptual features, represented comparatively late parietal areas. A separately acquired EEG dataset then used track temporal evolution reactivated using similarity-based EEG–fMRI fusion. This fusion suggests memory proceeds anterior frontotemporal posterior occipital regions, line conceptual-to-perceptual gradient only partly following same as linear regression statistically confirms sequential activation ventral stream image retrieval. The analysis also an information relay frontoparietal areas Together, results shed light onto dynamics recall undergoes experience its later memory.

Language: Английский

Citations

2
A combined DTI‐fMRI approach for optimizing the delineation of posteromedial versus anterolateral entorhinal cortex DOI Creative Commons
Ingrid Framås Syversen, Daniel Reznik, Menno P. Witter

et al.

Hippocampus, Journal Year: 2024, Volume and Issue: 34(11), P. 659 - 672

Published: Sept. 21, 2024

Abstract In the entorhinal cortex (EC), attempts have been made to identify human homologue regions of medial (MEC) and lateral (LEC) subregions using either functional magnetic resonance imaging (fMRI) or diffusion tensor (DTI). However, there are still discrepancies between subdivisions depending on choice connectivity seed modality used. While DTI can be used follow white matter tracts brain, fMRI functionally connected brain regions. this study, we both resting‐state in 103 healthy adults investigate structural EC associated cortical Differential with these was then predict locations homologues MEC LEC. Our results from combining support a subdivision into posteromedial (pmEC) anterolateral (alEC) reveal confined border pmEC alEC. Furthermore, obtained by showed similar distinct whole‐brain profiles. Optimizing delineation LEC combined, cross‐validated DTI‐fMRI approach allows define likely two has implications for cognitive translational neuroscience research.

Language: Английский

Citations

2
Subsegmentation of the hippocampus in subgroups of migraine with aura patients: advanced structural neuroimaging study DOI Creative Commons
Igor Petrušić,

Mojsije Radović,

Marko Daković

et al.

The Journal of Headache and Pain, Journal Year: 2024, Volume and Issue: 25(1)

Published: Oct. 17, 2024

This study investigated for a possible contributing role of hippocampus in the different clinical phenotypic manifestations migraine aura.

Language: Английский

Citations

2
Longitudinal hippocampal axis in large-scale cortical systems underlying development and episodic memory DOI Creative Commons
Hua Xie, Venkata Sita Priyanka Illapani,

Lauren Reppert

et al.

Proceedings of the National Academy of Sciences, Journal Year: 2024, Volume and Issue: 121(44)

Published: Oct. 22, 2024

The hippocampus is functionally specialized along its longitudinal axis with intricate interactions cortical systems, which crucial for understanding development and cognition. Using a well-established connectopic mapping technique on two large resting-state functional MRI datasets, we systematically quantified topographic organization of the hippocampal connectivity (hippocampal gradient) interaction in developing brains. We revealed hierarchy within large-scale brain anterior preferentially connected to an temporal (AT) pathway posterior embedded medial (PM) pathway. examined developmental effects primary gradient whole-brain interaction. observed increased specialization long found general shift from during development. phenotypic predictive modeling, further delineated how differentially integrated into underlying episodic memory identified several key nodes PM/AT systems. Our results highlight importance supporting memory.

Language: Английский

Citations

2