Sex-dependent, lateralized engagement of anterior insular cortex inputs to the dorsolateral striatum in binge alcohol drinking

eLife, Journal Year: 2024, Volume and Issue: 13

Published: Aug. 28, 2024

How does alcohol consumption alter synaptic transmission across time, and do these alcohol-induced neuroadaptations occur similarly in both male female mice? Previously we identified that anterior insular cortex (AIC) projections to the dorsolateral striatum (DLS) are uniquely sensitive male, but not mice, play a role governing binge mice (Haggerty et al., 2022). Here, by using high-resolution behavior data paired with in-vivo fiber photometry, show how similar levels of intake achieved via different behavioral strategies sexes, inter-drinking session thirst states predict future intakes females, males. Furthermore, presynaptic calcium activity recorded from AIC inputs DLS 3 weeks water followed changes across, fluid, sex, brain circuit lateralization. By time-locking peri-initiation drinking events also into left robustly encode behaviors relative consumption. These findings suggest fluid-, sex-, lateralization-dependent for engagement further contextualize at DLS.

Language: Английский

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Lickometry to Circuitry: How Compulsion-Like Alcohol Drinking Microstructure Helped Discover Functional Differences in Salience Network Regions

Neuromethods, Journal Year: 2023, Volume and Issue: unknown, P. 55 - 77

Published: Jan. 1, 2023

Problem alcohol drinking remains an enormous personal, social, and clinical challenge, compulsion-like (intake despite known negative consequences) can strongly contribute. Here we describe the lickometry method, a simple procedure (determining lick times) but, by analyzing many aspects of licking (or some other behavior), but with potential to provide important insights into underlying psychological action strategies. We compare moderate challenge or higher (ModChD HiChD, quinine-alcohol) versus alcohol-only (AOD). Classic studies suggest two main strategies during oral intake, more bouts (indicating motivation), longer (often faster) palatability). In strong contrast, ModChD shows decreased variability measures, from speed tongue shape, consistent importance automaticity in addiction. Further, surprisingly, HiChD retains (and earlier bout start) seen ModChD-versus-AOD, along greatly disrupted intake. relate these changes regions Salience Network, which identifies responds events. collapses mirrors inhibiting dorsal-medial prefrontal cortex (dMPF), while anterior insula (AIC/ventral-frontal cortex) is linked value-driven plan also consumption. While AIC-dMPF likely work together, find novel dissociation AIC-versus-dMPF function: AIC provides overall drive firm commitment regardless level, dMPF organizes across time, battle for acting won lost dMPF.

Language: Английский

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Neural correlates of valence-dependent belief and value updating during uncertainty reduction: An fNIRS study

NeuroImage, Journal Year: 2023, Volume and Issue: 279, P. 120327 - 120327

Published: Aug. 13, 2023

Selective use of new information is crucial for adaptive decision-making. Combining a gamble bidding task with assessing cortical responses using functional near-infrared spectroscopy (fNIRS), we investigated potential effects valence on behavioral and neural processes belief value updating during uncertainty reduction in young adults. By modeling changes the participants' expressed subjective values Bayesian model, dissociated (i) beliefs about statistical properties gamble, (ii) based its winning probabilities, as well (iii) expectancy violation. The results showed that participants used to update their gambles quasi-optimal manner, reflected selective only situations reducible uncertainty. Furthermore, was valence-dependent: indicating an increase probability underweighted, whereas decrease updated good agreement predictions decision theory. Results model-based moderation analyses this valence-dependent asymmetry associated distinct contribution violation, besides updating, after experiencing positive regarding probabilities. In line results, replicated previous findings showing involvements frontoparietal brain regions different components updating. study provided novel suggesting recruitment regions. Individuals stronger oxyhemoglobin more model while integrating indicates probability. Taken together, provides first violation contributing factor sub-optimal suggests limitations normative

Language: Английский

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Chronic alcohol induces subcircuit-specific striatonigral plasticity shifting action control to the sensorimotor striatum

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: Nov. 15, 2023

Abstract While cortico-striatal circuit deficits contribute to Alcohol Use Disorder, the impact of alcohol on synaptic function in basal ganglia output, substantia nigra pars reticulata (SNr), remains unclear. Here, we found that inputs from dorsomedial (DMS) and dorsolateral striatum (DLS) differ their presynaptic properties target molecularly distinct subpopulations SNr neurons. We also discovered indirect pathway subthalamic (STN) medial lateral have different STN are stronger SNr. Chronic exposure (CIE) potentiated DLS but did not affect strength release DMS Chemogenetic inhibition direct projection neurons impaired action performance an operant conditioning task CIE mice control mice. Overall, our work identifies a mechanism whereby chronic induces gain for striatum. Teaser selectively potentiates SNr, enhancing role control.

Language: Английский

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Forced Abstinence from Volitional Ethanol Intake Drives a Vulnerable Period of Hyperexcitability in BNST-Projecting Insular Cortex Neurons

Journal of Neuroscience, Journal Year: 2023, Volume and Issue: 44(4), P. e1121232023 - e1121232023

Published: Nov. 22, 2023

The insular cortex (IC) integrates sensory and interoceptive cues to inform downstream circuitry executing adaptive behavioral responses. IC communicates with areas involved canonically in stress motivation. projections govern ethanol recruitment of bed nucleus the stria terminalis (BNST) activity necessary for emergence negative affective behaviors during alcohol abstinence. Here, we assess impact chronic drinking forced abstinence (CDFA) volitional home cage intake paradigm on synaptic excitable properties neurons that project BNST (IC →BNST ). Using whole-cell patch-clamp electrophysiology, investigated 24 h or 2 weeks following (FA) female C57BL6/J mice. We find cells are transiently more acute withdrawal. In contrast, vivo exposure via intraperitoneal injection, ex wash, FA from a natural reward (sucrose) all failed alter excitability. situ hybridization studies revealed at post BK channel mRNA expression is reduced IC. Further, pharmacological inhibition channels mimicked phenotype, while activation was able decrease AP firing control subjects. All together these data suggest novel mechanism homeostatic plasticity occurs drinking.

Language: Английский

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