Long- and short-term history effects in a spiking network model of statistical learning DOI Creative Commons
Amadeus Maes, Mauricio Barahona, Claudia Clopath

et al.

Scientific Reports, Journal Year: 2023, Volume and Issue: 13(1)

Published: Aug. 9, 2023

Abstract The statistical structure of the environment is often important when making decisions. There are multiple theories how brain represents structure. One such theory states that neural activity spontaneously samples from probability distributions. In other words, network spends more time in which encode high-probability stimuli. Starting assembly, increasingly thought to be building block for computation brain, we focus on arbitrary prior knowledge about external world can both learned and recollected. We present a model based upon learning inverse cumulative distribution function. Learning entirely unsupervised using biophysical neurons biologically plausible rules. show this then accessed compute expectations signal surprise downstream networks. Sensory history effects emerge as consequence ongoing learning.

Language: Английский

All-optical physiology resolves a synaptic basis for behavioral timescale plasticity DOI Creative Commons
Linlin Z. Fan, Doo Kyung Kim,

Joshua H. Jennings

et al.

Cell, Journal Year: 2023, Volume and Issue: 186(3), P. 543 - 559.e19

Published: Jan. 19, 2023

Learning has been associated with modifications of synaptic and circuit properties, but the precise changes storing information in mammals have remained largely unclear. We combined genetically targeted voltage imaging optogenetic activation silencing pre- post-synaptic neurons to study mechanisms underlying hippocampal behavioral timescale plasticity. In mice navigating a virtual-reality environment, individual CA1 cells at specific places induced stable representations these cells. Optical elicitation, recording, modulation transmission behaving revealed that activity presynaptic CA2/3 was required for induction plasticity and, furthermore, during place fields single cells, input from onto same potentiated. These results reveal implementation define methodology resolve learning memory mammals.

Language: Английский

Citations

94
A locus coeruleus-dorsal CA1 dopaminergic circuit modulates memory linking DOI Creative Commons
Ananya Chowdhury, Alessandro Luchetti, Giselle Fernandes

et al.

Neuron, Journal Year: 2022, Volume and Issue: 110(20), P. 3374 - 3388.e8

Published: Aug. 29, 2022

Language: Английский

Citations

84
Engram neurons: Encoding, consolidation, retrieval, and forgetting of memory DOI Creative Commons

Axel Guskjolen,

Mark S. Cembrowski

Molecular Psychiatry, Journal Year: 2023, Volume and Issue: 28(8), P. 3207 - 3219

Published: June 27, 2023

Tremendous strides have been made in our understanding of the neurobiological substrates memory - so-called "engram". Here, we integrate recent progress engram field to illustrate how neurons transform across "lifespan" a from initial encoding, consolidation and retrieval, ultimately forgetting. To do so, first describe cell-intrinsic properties shape emergence at encoding. Second, highlight these encoding preferentially participate synaptic- systems-level memory. Third, changes during guide neural reactivation facilitate recall. Fourth, mechanisms forgetting, can counteract established consolidation, retrieval. Motivated by experimental results four sections, conclude proposing some conceptual extensions traditional view engram, including broadening cell-type participation within engrams stages. In collection, review synthesizes general principles stages, describes future avenues further understand dynamic engram.

Language: Английский

Citations

47
Neuronal ensembles: Building blocks of neural circuits DOI Creative Commons
Rafael Yuste, Rosa Cossart, Emre Yaksi

et al.

Neuron, Journal Year: 2024, Volume and Issue: 112(6), P. 875 - 892

Published: Jan. 22, 2024

Language: Английский

Citations

36
Brain Plasticity and Cell Competition: Immediate Early Genes Are the Focus DOI Creative Commons
Pavel P. Tregub, Yulia K. Komleva,

Maria V. Kukla

et al.

Cells, Journal Year: 2025, Volume and Issue: 14(2), P. 143 - 143

Published: Jan. 19, 2025

Brain plasticity is at the basis of many cognitive functions, including learning and memory. It includes several mechanisms synaptic extrasynaptic changes, neurogenesis, formation elimination synapses. The transmission involves expression immediate early genes (IEGs) that regulate neuronal activity, thereby supporting In addition, IEGs are involved in regulation brain cells’ metabolism, proliferation, survival, establishment multicellular ensembles, and, presumably, cell competition tissue. this review, we analyze current understanding role (c-Fos, c-Myc, Arg3.1/Arc) controlling physiological pathological conditions, aging neurodegeneration. This work might inspire new gene therapy strategies targeting to plasticity, potentially prevent or mitigate neurodegenerative diseases.

Language: Английский

Citations

2
How many neurons are sufficient for perception of cortical activity? DOI Creative Commons
Henry Dalgleish, Lloyd Russell, Adam M. Packer

et al.

eLife, Journal Year: 2020, Volume and Issue: 9

Published: Oct. 26, 2020

Many theories of brain function propose that activity in sparse subsets neurons underlies perception and action. To place a lower bound on the amount neural can be perceived, we used an all-optical approach to drive behaviour with targeted two-photon optogenetic activation small ensembles L2/3 pyramidal mouse barrel cortex while simultaneously recording local network calcium imaging. By precisely titrating number stimulated, demonstrate for cortical is ~14 neurons. We find steep sigmoidal relationship between activated behaviour, saturating at only ~37 neurons, show this shift learning. Furthermore, balanced by inhibition neighbouring This surprising perceptual sensitivity face potent suppression supports coding hypothesis, suggests balances trade-off minimizing impact noise efficiently detecting relevant signals.

Language: Английский

Citations

111
Intrinsic excitability mechanisms of neuronal ensemble formation DOI Creative Commons
Tzitzitlini Alejandre-García, Samuel Kim, Jesús Pérez-Ortega

et al.

eLife, Journal Year: 2022, Volume and Issue: 11

Published: May 4, 2022

Neuronal ensembles are coactive groups of cortical neurons, found in spontaneous and evoked activity, that can mediate perception behavior. To understand the mechanisms lead to formation ensembles, we co-activated layer 2/3 pyramidal neurons brain slices from mouse visual cortex, animals both sexes, replicating vitro an optogenetic protocol generate vivo. Using whole-cell perforated patch-clamp pair recordings that, after or electrical stimulation, coactivated increased their correlated a hallmark ensemble formation. Coactivated showed small biphasic changes presynaptic plasticity, with initial depression followed by potentiation recovery period. Optogenetic stimulation also induced significant increases frequency amplitude EPSPs, even single-cell stimulation. In addition, observed unexpected strong persistent neuronal excitability membrane resistance reductions spike threshold. A pharmacological agent blocks reverted this effect. These explain synaptic plasticity. We conclude cell-intrinsic involved ensembles. propose ‘iceberg’ model, which makes subthreshold connections suprathreshold, enhancing effect already existing synapses, generating new ensemble.

Language: Английский

Citations

47
Hyperpolarization-activated channel 1 modulates resilience and susceptibility to social avoidance induced by witnessing social defeat stress DOI Creative Commons
Jiwon Kim,

S Michael,

Kritika Pokharel

et al.

Biological Psychiatry, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Physical social defeat stress models are widely used to study chronic stress. In contrast, witnessing defeat, observing aggression without direct involvement, is less studied but has growing relevance disorders such as post-traumatic disorder (PTSD). The role of hyperpolarization-activated cation channel 1 (HCN1) in responses unclear, and the effects prolonged exposure (PE) therapy, commonly PTSD treatment, have not been tested this context. Male mice were either subjected physical or Behavioral assessments included measures avoidance, reactivity, fear memory, spatial working memory. Neuronal excitability, h current (Ih), synaptic transmission dorsal hippocampal CA1 neurons measured using whole-cell patch-clamp recordings. Conditional overexpression deletion HCN1 was employed further examine its role. Witnessing-defeated underwent 12 days PE treatment. Mice that witnessed exhibited behavioral impairments like physically defeated mice, showing changes behavior, responses. These linked increased expression, elevated Ih, reduced neuronal excitability. Overexpression induced susceptibility-like behaviors, while promoted resilience-like behaviors. Impaired AMPA receptor at distal dendrites witness-susceptible replicated by reversed ZD7288, an HCN blocker. PE-resistant displayed PE-responsive normal-like channels play a key regulating contribute resilience susceptibility following defeat.

Language: Английский

Citations

1
Formation and computational implications of assemblies in neural circuits DOI Creative Commons
Christoph Miehl, Sebastian Onasch, Dylan Festa

et al.

The Journal of Physiology, Journal Year: 2022, Volume and Issue: 601(15), P. 3071 - 3090

Published: Sept. 7, 2022

Abstract In the brain, patterns of neural activity represent sensory information and store it in non‐random synaptic connectivity. A prominent theoretical hypothesis states that assemblies, groups neurons are strongly connected to each other, key computational units underlying perception memory formation. Compatible with these hypothesised experiments have revealed display synchronous activity, either spontaneously or upon stimulus presentation, exhibit behavioural relevance. While remains unclear how assemblies form work has vastly contributed understanding various interacting mechanisms this process. Here, we review recent literature on assembly formation by categorising involved into four components: plasticity, symmetry breaking, competition stability. We highlight different approaches assumptions behind discuss ideas as unit brain. image

Language: Английский

Citations

23
Neural ensembles: role of intrinsic excitability and its plasticity DOI Creative Commons
Christian Hansel,

Rafael Yuste

Frontiers in Cellular Neuroscience, Journal Year: 2024, Volume and Issue: 18

Published: July 31, 2024

Synaptic connectivity defines groups of neurons that engage in correlated activity during specific functional tasks. These co-active form ensembles, the operational units involved in, for example, sensory perception, motor coordination and memory (then called an

Language: Английский

Citations

6