The roles of feedback loops in the Caenorhabditis elegans rhythmic forward locomotion DOI
Tao Fang, Peng Zhao, Boyang Wang

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 17, 2024

Abstract Rhythmic behaviors are of paramount importance in biological systems, particularly animal locomotion. However, the circuit mechanisms underlying these remain incompletely understood. While central pattern generator has been instrumental explaining many rhythmic locomotion patterns, it is insufficient to account for flexible tunability frequency and amplitude certain oscillatory movements. This suggests involvement additional, less understood circuits. study employs calcium imaging neuromechanical modeling investigate mechanism responsible sinusoidal forward Caenorhabditis elegans. We demonstrate that a feedback loop circuit, consisting motoneurons muscles, governs generation oscillations regulates movement. composed both negative positive pathways, which together regulate oscillation dynamics. The includes muscle-to-motoneuron inhibitory signal, determining generation, whereas incorporates proprioceptive from muscles motoneurons. These loops coordinate modulate turnability, directing activities into three distinct patterns: stable oscillation, unilateral non-oscillation. behavior C. elegans typically involves alternation dorsal ventral muscles. Our model functional unit reveals asymmetric inputs interneurons motoneurons, as well connections essential this switching mechanism. findings suggest that, addition established role generators, circuits formed by may contribute more modulatory behaviors.

Language: Английский

Changes in the cellular makeup of motor patterning circuits drive courtship song evolution in Drosophila DOI
Dajia Ye, Justin Walsh, Ian P. Junker

et al.

Current Biology, Journal Year: 2024, Volume and Issue: 34(11), P. 2319 - 2329.e6

Published: April 29, 2024

Language: Английский

Citations

15
Changes in the cellular makeup of motor patterning circuits drive courtship song evolution inDrosophila DOI Creative Commons
Dajia Ye, Justin Walsh, Ian P. Junker

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 24, 2024

Abstract How evolutionary changes in genes and neurons encode species variation complex motor behaviors are largely unknown. Here, we develop genetic tools that permit a neural circuit comparison between the model Drosophila melanogaster closely-related D. yakuba , who has undergone lineage-specific loss of sine song, one two major types male courtship song . Neuroanatomical patterning called TN1 across phylogeny demonstrates link reduction both number neurites serving connectivity. Optogenetic activation confirms have lost ability to drive while maintaining singing wing posture. Single-cell transcriptomic shows specifically lacks cell type corresponding TN1A neurons, subtype is essential for song. Genetic developmental manipulation reveals functional divergence sex determination gene doublesex reduce by promoting apoptosis. Our work illustrates contribution circuits behavioral evolution, uncovers lability reconfigure cellular makeup circuits.

Language: Английский

Citations

0
The roles of feedback loops in the Caenorhabditis elegans rhythmic forward locomotion DOI
Tao Fang, Peng Zhao, Boyang Wang

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 17, 2024

Abstract Rhythmic behaviors are of paramount importance in biological systems, particularly animal locomotion. However, the circuit mechanisms underlying these remain incompletely understood. While central pattern generator has been instrumental explaining many rhythmic locomotion patterns, it is insufficient to account for flexible tunability frequency and amplitude certain oscillatory movements. This suggests involvement additional, less understood circuits. study employs calcium imaging neuromechanical modeling investigate mechanism responsible sinusoidal forward Caenorhabditis elegans. We demonstrate that a feedback loop circuit, consisting motoneurons muscles, governs generation oscillations regulates movement. composed both negative positive pathways, which together regulate oscillation dynamics. The includes muscle-to-motoneuron inhibitory signal, determining generation, whereas incorporates proprioceptive from muscles motoneurons. These loops coordinate modulate turnability, directing activities into three distinct patterns: stable oscillation, unilateral non-oscillation. behavior C. elegans typically involves alternation dorsal ventral muscles. Our model functional unit reveals asymmetric inputs interneurons motoneurons, as well connections essential this switching mechanism. findings suggest that, addition established role generators, circuits formed by may contribute more modulatory behaviors.

Language: Английский

Citations

0