Comparative Roles of the Caudate and Putamen in the Serial Order of Behavior: Effects of Striatal Glutamate Receptor Blockade on Variable versus Fixed Spatial Self-Ordered Sequencing in Marmosets DOI Creative Commons
Stacey Anne Gould,

Amy R. Hodgson,

Hannah F. Clarke

et al.

eNeuro, Journal Year: 2024, Volume and Issue: 11(3), P. ENEURO.0541 - 23.2024

Published: March 1, 2024

Self-ordered sequencing is an important executive function involving planning and executing a series of steps to achieve goal-directed outcomes. The lateral frontal cortex implicated in this behavior, but downstream striatal outputs remain relatively unexplored. We trained marmosets on three-stimulus self-ordered spatial task using touch-sensitive screen explore the role caudate nucleus putamen random fixed response arrays. By transiently blocking glutamatergic inputs these regions, intrastriatal CNQX microinfusions, we demonstrate that are both required for, contribute differently to, flexible sequencing. into either or impaired variable array accuracy, infusions simultaneously elicited greater impairment. demonstrated continuous perseverative errors were caused by infusions, likely due interference with putamen's established monitoring motor feedback. Caudate however, did not affect errors, cause upward trend recurrent perseveration, possibly reflecting caudate's working memory planning. In contrast performance, while responding, combined effects additive, suggesting possible competing roles. Infusions region individually, simultaneously, led perseveration. Recurrent perseveration arrays was putamen, caudate, infusions. These results consistent overall responding more rigid habitual automatic responding.

Language: Английский

The different mediation role of habit features between intolerance of uncertainty and psychopathological symptom dimensions: A transdiagnostic perspective DOI

Chenyu Yuan,

Yinqing Fan,

Chaoyi Wu

et al.

Journal of Affective Disorders, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

Citations

0
Distinct cognitive and functional connectivity features from healthy cohorts inform clinical obsessive-compulsive disorder DOI Creative Commons
Luke J. Hearne, B.T. Thomas Yeo, Lachlan Webb

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 3, 2024

Improving diagnostic accuracy of obsessive-compulsive disorder (OCD) using models brain imaging data is a key goal the field, but this objective challenging due to limited size and phenotypic depth clinical datasets. Leveraging diversity in large non-clinical datasets such as UK Biobank (UKBB), offers potential solution problem. Nevertheless, it remains unclear whether classification trained on populations will generalise individuals with OCD. This question also relevant for conceptualisation OCD; specifically, symptomology OCD exists continuum from normal pathological. Here, we examined recently published "meta-matching" model functional connectivity five normative (N=45,507) predict cognitive, health demographic variables. Specifically, tested could classify status three independent (N=345). We found that identify out-of-sample individuals. Notably, most predictive features mapped onto known cortico-striatal abnormalities correlated genetic expression maps previously implicated disorder. Further, meta-matching relied upon estimates cognitive functions, flexibility inhibition, successfully These findings suggest variability behavioural can discriminate status. results support dimensional transdiagnostic basis OCD, implications research approaches treatment targets.

Language: Английский

Citations

1
Validation of the Dutch version of the Creature of Habit Scale (COHS): a self-report measure of the tendency for habitual behavior in daily life DOI Open Access

Hanne Dewaelle,

Tom Verguts, Elise Lesage

et al.

Published: Jan. 3, 2024

Many of our everyday actions are made habitually, without conscious deliberation or weighing alternative actions. Habits efficient, but difficult to break. People differ in their tendency form habits, and these differences may relate an individual’s risk disorders compulsivity, which associated with such as obsessive-compulsive disorder substance abuse disorders. To assess the individual for habit formation, Ersche et al. (2017) developed Creature scale (COHS) measures habitual behavior life, broken down into subscales automatisms routines. Impulsivity compulsivity thought be subscales. Here, we carry out a preregistered validation Dutch translation COHS Dutch-speaking sample (N=411). An exploratory factor analysis replicated original distinction between scales automatism routine. A further confirmatory relationship traits impulsivity compulsivity. Finally, explored problematic alcohol use. We conclude that version Habit Scale can used routine automaticity population.

Language: Английский

Citations

0
Comparative Roles of the Caudate and Putamen in the Serial Order of Behavior: Effects of Striatal Glutamate Receptor Blockade on Variable versus Fixed Spatial Self-Ordered Sequencing in Marmosets DOI Creative Commons
Stacey Anne Gould,

Amy R. Hodgson,

Hannah F. Clarke

et al.

eNeuro, Journal Year: 2024, Volume and Issue: 11(3), P. ENEURO.0541 - 23.2024

Published: March 1, 2024

Self-ordered sequencing is an important executive function involving planning and executing a series of steps to achieve goal-directed outcomes. The lateral frontal cortex implicated in this behavior, but downstream striatal outputs remain relatively unexplored. We trained marmosets on three-stimulus self-ordered spatial task using touch-sensitive screen explore the role caudate nucleus putamen random fixed response arrays. By transiently blocking glutamatergic inputs these regions, intrastriatal CNQX microinfusions, we demonstrate that are both required for, contribute differently to, flexible sequencing. into either or impaired variable array accuracy, infusions simultaneously elicited greater impairment. demonstrated continuous perseverative errors were caused by infusions, likely due interference with putamen's established monitoring motor feedback. Caudate however, did not affect errors, cause upward trend recurrent perseveration, possibly reflecting caudate's working memory planning. In contrast performance, while responding, combined effects additive, suggesting possible competing roles. Infusions region individually, simultaneously, led perseveration. Recurrent perseveration arrays was putamen, caudate, infusions. These results consistent overall responding more rigid habitual automatic responding.

Language: Английский

Citations

0