Comparative Roles of the Caudate and Putamen in the Serial Order of Behavior: Effects of Striatal Glutamate Receptor Blockade on Variable versus Fixed Spatial Self-Ordered Sequencing in Marmosets DOI Creative Commons
Stacey Anne Gould,

Amy R. Hodgson,

Hannah F. Clarke

et al.

eNeuro, Journal Year: 2024, Volume and Issue: 11(3), P. ENEURO.0541 - 23.2024

Published: March 1, 2024

Self-ordered sequencing is an important executive function involving planning and executing a series of steps to achieve goal-directed outcomes. The lateral frontal cortex implicated in this behavior, but downstream striatal outputs remain relatively unexplored. We trained marmosets on three-stimulus self-ordered spatial task using touch-sensitive screen explore the role caudate nucleus putamen random fixed response arrays. By transiently blocking glutamatergic inputs these regions, intrastriatal CNQX microinfusions, we demonstrate that are both required for, contribute differently to, flexible sequencing. into either or impaired variable array accuracy, infusions simultaneously elicited greater impairment. demonstrated continuous perseverative errors were caused by infusions, likely due interference with putamen's established monitoring motor feedback. Caudate however, did not affect errors, cause upward trend recurrent perseveration, possibly reflecting caudate's working memory planning. In contrast performance, while responding, combined effects additive, suggesting possible competing roles. Infusions region individually, simultaneously, led perseveration. Recurrent perseveration arrays was putamen, caudate, infusions. These results consistent overall responding more rigid habitual automatic responding.

Language: Английский

Comparative Roles of the Caudate and Putamen in the Serial Order of Behavior: Effects of Striatal Glutamate Receptor Blockade on Variable versus Fixed Spatial Self-Ordered Sequencing in Marmosets DOI Creative Commons
Stacey Anne Gould,

Amy R. Hodgson,

Hannah F. Clarke

et al.

eNeuro, Journal Year: 2024, Volume and Issue: 11(3), P. ENEURO.0541 - 23.2024

Published: March 1, 2024

Self-ordered sequencing is an important executive function involving planning and executing a series of steps to achieve goal-directed outcomes. The lateral frontal cortex implicated in this behavior, but downstream striatal outputs remain relatively unexplored. We trained marmosets on three-stimulus self-ordered spatial task using touch-sensitive screen explore the role caudate nucleus putamen random fixed response arrays. By transiently blocking glutamatergic inputs these regions, intrastriatal CNQX microinfusions, we demonstrate that are both required for, contribute differently to, flexible sequencing. into either or impaired variable array accuracy, infusions simultaneously elicited greater impairment. demonstrated continuous perseverative errors were caused by infusions, likely due interference with putamen's established monitoring motor feedback. Caudate however, did not affect errors, cause upward trend recurrent perseveration, possibly reflecting caudate's working memory planning. In contrast performance, while responding, combined effects additive, suggesting possible competing roles. Infusions region individually, simultaneously, led perseveration. Recurrent perseveration arrays was putamen, caudate, infusions. These results consistent overall responding more rigid habitual automatic responding.

Language: Английский

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