The role of REM sleep in neural differentiation of memories in the hippocampus DOI Creative Commons
Elizabeth A. McDevitt,

Ghootae Kim,

Nicholas B. Turk‐Browne

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 3, 2024

When faced with a familiar situation, we can use memory to make predictions about what will happen next. If such turn out be erroneous, the brain adapt by differentiating representations of cues that generated prediction from mispredicted item itself, reducing likelihood future errors. Prior work Kim et al. (2017) found violating sequential association in statistical learning paradigm triggered differentiation neural associated items hippocampus. Here, used fMRI test preregistered hypothesis this hippocampal occurs only when violations are followed rapid eye movement (REM) sleep. In morning, participants first learned some predict others (e.g., A predicts B) then encountered violation which predicted (B) failed appear expected after its (A); later appeared on own an unrelated item. Participants were randomly assigned one three conditions: remain awake, take nap containing non-REM sleep only, or both and REM While results not observed left CA2/3/DG ROI, did observe evidence for our closely related ROIs, uncorrected multiple comparisons: right CA2/3/DG, group was greater than groups without (wake nap); item-specific concentrated DG. Differentiation effects also bilateral DG more strongly reactivated during violation. Overall, presented here provide initial linking changes memories humans.

Language: Английский

Inducing representational change in the hippocampus through real-time neurofeedback DOI Creative Commons
Kailong Peng, Jeffrey D. Wammes, Alex Nguyen

et al.

Philosophical Transactions of the Royal Society B Biological Sciences, Journal Year: 2024, Volume and Issue: 379(1915)

Published: Oct. 21, 2024

When you perceive or remember something, other related things come to mind, affecting how these competing items are subsequently perceived and remembered. Such behavioural consequences believed result from changes in the overlap of neural representations items, especially hippocampus. According multiple theories, hippocampal should increase (integration) when there is high coactivation between cortical representations. However, prior studies used indirect proxies for by manipulating stimulus similarity task demands. Here, we induce visual cortex more directly using closed-loop neurofeedback real-time functional magnetic resonance imaging (fMRI). While viewing one object, participants were rewarded activating representation another object as strongly possible. Across fMRI sessions, succeeded this coactivation. Compared with a baseline untrained objects, protocol led memory integration behaviour brain: trained objects became harder discriminate behaviourally categorical perception neurally patterns activity their hippocampus losing unique features. These findings demonstrate that can be alter combine memories. This article part theme issue ‘Neurofeedback: new territories neurocognitive mechanisms endogenous neuromodulation’.

Language: Английский

Citations

3
Differentiation of related events in hippocampus supports memory reinstatement in development DOI Creative Commons

Nicole L. Varga,

Hannah E. Roome, Robert J. Molitor

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: May 25, 2023

Abstract Adults are capable of either differentiating or integrating similar events in memory based on which representations optimal for a given situation. Yet how children represent related memories remains unknown. Here, (7-10 years) and adults formed separate yet overlapping events. We then measured successfully remembered were represented reinstated using functional magnetic resonance imaging (fMRI). found that differentiated hippocampus—such stored as less to one another compared unrelated Conversely, integrated representations, wherein more similar, including medial prefrontal cortex (mPFC). Furthermore, hippocampal differentiation among mPFC integration tracked neocortical reinstatement the specific features associated with individual Together, these findings reveal same behaviors supported by different underlying across development. Specifically, whereas underlies organization retrieval childhood, exhibits protracted developmental trajectory.

Language: Английский

Citations

1
The role of REM sleep in neural differentiation of memories in the hippocampus DOI Creative Commons
Elizabeth A. McDevitt,

Ghootae Kim,

Nicholas B. Turk‐Browne

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 3, 2024

When faced with a familiar situation, we can use memory to make predictions about what will happen next. If such turn out be erroneous, the brain adapt by differentiating representations of cues that generated prediction from mispredicted item itself, reducing likelihood future errors. Prior work Kim et al. (2017) found violating sequential association in statistical learning paradigm triggered differentiation neural associated items hippocampus. Here, used fMRI test preregistered hypothesis this hippocampal occurs only when violations are followed rapid eye movement (REM) sleep. In morning, participants first learned some predict others (e.g., A predicts B) then encountered violation which predicted (B) failed appear expected after its (A); later appeared on own an unrelated item. Participants were randomly assigned one three conditions: remain awake, take nap containing non-REM sleep only, or both and REM While results not observed left CA2/3/DG ROI, did observe evidence for our closely related ROIs, uncorrected multiple comparisons: right CA2/3/DG, group was greater than groups without (wake nap); item-specific concentrated DG. Differentiation effects also bilateral DG more strongly reactivated during violation. Overall, presented here provide initial linking changes memories humans.

Language: Английский

Citations

0