Calcium signaling in endothelial and vascular smooth muscle cells: sex differences and the influence of estrogens and androgens
AJP Heart and Circulatory Physiology,
Journal Year:
2024,
Volume and Issue:
326(4), P. H950 - H970
Published: Feb. 9, 2024
Calcium
signaling
in
vascular
endothelial
cells
(ECs)
and
smooth
muscle
(VSMCs)
is
essential
for
the
regulation
of
tone.
However,
changes
to
intracellular
Ca
Language: Английский
Multi‐scale modelling of the effects of ageing, hypertension and exercise on the cerebral vasculature
The Journal of Physiology,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 13, 2025
Ageing
and
hypertension
both
have
substantial,
well-documented
effects
on
the
cerebral
vasculature.
The
of
aerobic
exercise
cerebrovascular
function
development,
although
less
well
understood,
also
recently
received
significantly
increased
attention.
There
is
now
clear
evidence
that
yields
short-
long-term
changes
to
health,
with
significant
potential
improve
population
brain
health.
However,
there
has
as
yet
been
no
mathematical
model
this,
making
it
challenging
quantify
exercise.
One
reason
for
this
very
different
time
scales
between
(minutes/hours)
development
(years/decades).
Here,
a
new
proposed,
one
incorporates
short-term
within
longer
scale.
calibrated
against
various
experimental
data
sources
used
ageing,
hypertension,
interventions
lifetime
predicts
high-intensity
positive
effect
health;
antihypertensive
treatment
even
after
prolonged
periods
hypertension;
can
strongly
interact
each
other.
This
provides
foundation
future
quantitative
investigations
into
critical
role
other
in
KEY
POINTS:
Exercise
vasculature,
which
counterbalance
negative
ageing
hypertension.
A
presented
all
three
using
multiple
include
effects.
range
regimes
health
first
time.
be
explore
lifestyles
Language: Английский
The formation of KV2.1 macro-clusters is required for sex-specific differences in L-type CaV1.2 clustering and function in arterial myocytes
Communications Biology,
Journal Year:
2023,
Volume and Issue:
6(1)
Published: Nov. 14, 2023
In
arterial
myocytes,
the
canonical
function
of
voltage-gated
Ca
Language: Английский
The formation of KV2.1 macro-clusters is required for sex-specific differences in L-type CaV1.2 clustering and function in arterial myocytes
Research Square (Research Square),
Journal Year:
2023,
Volume and Issue:
unknown
Published: July 19, 2023
Abstract
In
arterial
myocytes,
the
canonical
function
of
voltage-gated
Ca
V
1.2
and
K
2.1
channels
is
to
induce
myocyte
contraction
relaxation
through
their
responses
membrane
depolarization,
respectively.
Paradoxically,
also
plays
a
sex-specific
role
by
promoting
clustering
activity
channels.
However,
impact
protein
organization
on
remains
poorly
understood.
We
discovered
that
forms
micro-clusters,
which
can
transform
into
large
macro-clusters
when
critical
site
(S590)
in
channel
phosphorylated
myocytes.
Notably,
female
myocytes
exhibit
greater
phosphorylation
S590,
macro-cluster
formation
compared
males.
Contrary
current
models,
seems
unrelated
density
or
macro-clustering
Disrupting
(K
S590A
)
eliminated
differences
cluster
size
activity.
propose
degree
tunes
manner
Language: Английский
Amniotic membrane, a novel bioscaffold in cardiac diseases: from mechanism to applications
Frontiers in Bioengineering and Biotechnology,
Journal Year:
2024,
Volume and Issue:
12
Published: Dec. 20, 2024
Cardiovascular
diseases
represent
one
of
the
leading
causes
death
worldwide.
Despite
significant
advances
in
diagnosis
and
treatment
these
diseases,
numerous
challenges
remain
managing
them.
One
is
need
for
replacements
damaged
cardiac
tissues
that
can
restore
normal
function
heart.
Amniotic
membrane,
as
a
biological
scaffold
with
unique
properties,
has
attracted
attention
many
researchers
recent
years.
This
extracted
from
human
placenta,
contains
growth
factors,
cytokines,
other
biomolecules
play
crucial
role
tissue
repair.
Its
anti-inflammatory,
antibacterial,
wound-healing
properties
have
made
amniotic
membrane
promising
option
heart
diseases.
review
article
examines
applications
cardiovascular
By
focusing
on
mechanisms
action
this
results
clinical
studies,
an
attempt
will
be
to
evaluate
potential
using
Additionally,
existing
future
prospects
field
discussed.
Language: Английский