Amniotic membrane, a novel bioscaffold in cardiac diseases: from mechanism to applications DOI Creative Commons
Hossein Rayat Pisheh, Ahmad Darvishi,

Seyed Saeid Masoomkhah

et al.

Frontiers in Bioengineering and Biotechnology, Journal Year: 2024, Volume and Issue: 12

Published: Dec. 20, 2024

Cardiovascular diseases represent one of the leading causes death worldwide. Despite significant advances in diagnosis and treatment these diseases, numerous challenges remain managing them. One is need for replacements damaged cardiac tissues that can restore normal function heart. Amniotic membrane, as a biological scaffold with unique properties, has attracted attention many researchers recent years. This extracted from human placenta, contains growth factors, cytokines, other biomolecules play crucial role tissue repair. Its anti-inflammatory, antibacterial, wound-healing properties have made amniotic membrane promising option heart diseases. review article examines applications cardiovascular By focusing on mechanisms action this results clinical studies, an attempt will be to evaluate potential using Additionally, existing future prospects field discussed.

Language: Английский

Calcium signaling in endothelial and vascular smooth muscle cells: sex differences and the influence of estrogens and androgens DOI
Daniel Asunción‐Alvarez, Javier Palacios, Roberto O. Ybañez‐Julca

et al.

AJP Heart and Circulatory Physiology, Journal Year: 2024, Volume and Issue: 326(4), P. H950 - H970

Published: Feb. 9, 2024

Calcium signaling in vascular endothelial cells (ECs) and smooth muscle (VSMCs) is essential for the regulation of tone. However, changes to intracellular Ca

Language: Английский

Citations

11

Multi‐scale modelling of the effects of ageing, hypertension and exercise on the cerebral vasculature DOI
Stephen J. Payne

The Journal of Physiology, Journal Year: 2025, Volume and Issue: unknown

Published: April 13, 2025

Ageing and hypertension both have substantial, well-documented effects on the cerebral vasculature. The of aerobic exercise cerebrovascular function development, although less well understood, also recently received significantly increased attention. There is now clear evidence that yields short- long-term changes to health, with significant potential improve population brain health. However, there has as yet been no mathematical model this, making it challenging quantify exercise. One reason for this very different time scales between (minutes/hours) development (years/decades). Here, a new proposed, one incorporates short-term within longer scale. calibrated against various experimental data sources used ageing, hypertension, interventions lifetime predicts high-intensity positive effect health; antihypertensive treatment even after prolonged periods hypertension; can strongly interact each other. This provides foundation future quantitative investigations into critical role other in KEY POINTS: Exercise vasculature, which counterbalance negative ageing hypertension. A presented all three using multiple include effects. range regimes health first time. be explore lifestyles

Language: Английский

Citations

0

The formation of KV2.1 macro-clusters is required for sex-specific differences in L-type CaV1.2 clustering and function in arterial myocytes DOI Creative Commons
Collin Matsumoto, Samantha C. O’Dwyer, Declan Manning

et al.

Communications Biology, Journal Year: 2023, Volume and Issue: 6(1)

Published: Nov. 14, 2023

In arterial myocytes, the canonical function of voltage-gated Ca

Language: Английский

Citations

8

The formation of KV2.1 macro-clusters is required for sex-specific differences in L-type CaV1.2 clustering and function in arterial myocytes DOI Creative Commons
Luis F. Santana, Collin Matsumoto, Samantha C. O’Dwyer

et al.

Research Square (Research Square), Journal Year: 2023, Volume and Issue: unknown

Published: July 19, 2023

Abstract In arterial myocytes, the canonical function of voltage-gated Ca V 1.2 and K 2.1 channels is to induce myocyte contraction relaxation through their responses membrane depolarization, respectively. Paradoxically, also plays a sex-specific role by promoting clustering activity channels. However, impact protein organization on remains poorly understood. We discovered that forms micro-clusters, which can transform into large macro-clusters when critical site (S590) in channel phosphorylated myocytes. Notably, female myocytes exhibit greater phosphorylation S590, macro-cluster formation compared males. Contrary current models, seems unrelated density or macro-clustering Disrupting (K S590A ) eliminated differences cluster size activity. propose degree tunes manner

Language: Английский

Citations

3

Amniotic membrane, a novel bioscaffold in cardiac diseases: from mechanism to applications DOI Creative Commons
Hossein Rayat Pisheh, Ahmad Darvishi,

Seyed Saeid Masoomkhah

et al.

Frontiers in Bioengineering and Biotechnology, Journal Year: 2024, Volume and Issue: 12

Published: Dec. 20, 2024

Cardiovascular diseases represent one of the leading causes death worldwide. Despite significant advances in diagnosis and treatment these diseases, numerous challenges remain managing them. One is need for replacements damaged cardiac tissues that can restore normal function heart. Amniotic membrane, as a biological scaffold with unique properties, has attracted attention many researchers recent years. This extracted from human placenta, contains growth factors, cytokines, other biomolecules play crucial role tissue repair. Its anti-inflammatory, antibacterial, wound-healing properties have made amniotic membrane promising option heart diseases. review article examines applications cardiovascular By focusing on mechanisms action this results clinical studies, an attempt will be to evaluate potential using Additionally, existing future prospects field discussed.

Language: Английский

Citations

0