C. elegans wired and wireless connectome: insights into principles of nervous system structure and function

Journal of Biosciences, Journal Year: 2025, Volume and Issue: 50(1)

Published: March 12, 2025

Language: Английский

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Mapping and decoding neuropeptide signaling networks in nervous system function

Current Opinion in Neurobiology, Journal Year: 2025, Volume and Issue: 92, P. 103027 - 103027

Published: April 21, 2025

Neuropeptides are widespread signaling molecules that central to brain function in all animals. Recent advances profiling their expression across neural circuits, conjunction with detailed biochemical characterization of interactions receptors, have made it feasible build brain-wide maps neuropeptide signaling. Here, we discuss how recent reconstructions networks, from mammalian regions nervous system-wide C. elegans, reveal conserved organizational features neuropeptidergic networks. Furthermore, review technical breakthroughs vivo sensors for peptide release, receptor binding, and intracellular bring a mechanistic understanding networks within experimental reach. Finally, describe the architecture can change throughout evolution or even lifetime individuals, which highlights complexities must be considered understand these modulate circuit activity behavior different contexts.

Language: Английский

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Substance P in nonmammalian biology: Evolutionarily conserved tachykinin signaling

Elsevier eBooks, Journal Year: 2024, Volume and Issue: unknown, P. 27 - 77

Published: Nov. 8, 2024

Language: Английский

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