Mechanisms underlying the spontaneous reorganization of depression network after stroke DOI Creative Commons
Yirong Fang, Xian Chao,

Zeyu Lu

et al.

NeuroImage Clinical, Journal Year: 2024, Volume and Issue: 45, P. 103723 - 103723

Published: Dec. 11, 2024

Exploring the causal relationship between focal brain lesions and post-stroke depression (PSD) can provide therapeutic insights. However, a gap exists information. repair processes could bridge this gap. We defined network using normative connectome investigated predictive capacity of lesion-induced damage on depressive symptoms in discovery cohort 96 patients, at baseline six months post-stroke. Stepwise functional connectivity (SFC) was used to examine topological changes over time identify patterns reorganization. The value reorganization information evaluated for follow-up validation 1 (22 worsening PSD patients) as well treatment responsiveness 2 (23 antidepressant-treated patients). consistency significant areas with neuromodulation targets. Spatial correlations gene expression neurotransmitter maps were analyzed. power diminished compared (Δadjusted R

Language: Английский

Mechanisms underlying the spontaneous reorganization of depression network after stroke DOI Creative Commons
Yirong Fang, Xian Chao,

Zeyu Lu

et al.

NeuroImage Clinical, Journal Year: 2024, Volume and Issue: 45, P. 103723 - 103723

Published: Dec. 11, 2024

Exploring the causal relationship between focal brain lesions and post-stroke depression (PSD) can provide therapeutic insights. However, a gap exists information. repair processes could bridge this gap. We defined network using normative connectome investigated predictive capacity of lesion-induced damage on depressive symptoms in discovery cohort 96 patients, at baseline six months post-stroke. Stepwise functional connectivity (SFC) was used to examine topological changes over time identify patterns reorganization. The value reorganization information evaluated for follow-up validation 1 (22 worsening PSD patients) as well treatment responsiveness 2 (23 antidepressant-treated patients). consistency significant areas with neuromodulation targets. Spatial correlations gene expression neurotransmitter maps were analyzed. power diminished compared (Δadjusted R

Language: Английский

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